The role of miRNAs in polycystic ovary syndrome with insulin resistance

Luo, Yingliu; Cui, Chenchen; Han, Xiao; Wang, Qian; Zhang, Cuilian

doi:10.1007/s10815-020-02019-7

Cited by 21 publications

(17 citation statements)

References 196 publications

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“…MiRNAs [19], mutations and SNPs of nuclear-encoded genes (such as FSHR, LHCGR, DENND1A, THADA and others) have been linked to PCOS development and pathogenesis [20,21]. However, detailed characterisation of the mitochondrial DNA mutations linked to PCOS is scarce; available data is narrowed to small ethnic groups.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Dabravolski

Nikiforov

Eid

et al. 2021

IJMS

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Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Dabravolski

Nikiforov

Eid

et al. 2021

IJMS

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“…24 Síndrome de Ovario Poliquístico: El mecanismo etiológico de RI en pacientes con SOP se asocia al aumento de los andrógenos ováricos y suprarrenales, así como con el nivel de andrógenos libres por descenso de la SHBG o globulina transportadora de hormonas sexuales, jugando un papel además los trastornos ovulatorios y metabólicos, que incrementan riesgo cardiovascular, DM2 y HGENA; reportando que más del 60% de los pacientes con SOP tienen diversos grados de RI y su eficiencia en la ingesta de insulina es entre un 20% al 40% menor que el de las personas sanas. 25 Clínicamente, la RI se detecta mediante la evaluación del modelo de homeostasis de la RI (HOMA-IR) in vivo, y la precisión es equivalente técnica Clamp, sin embargo, existe una gran variabilidad en el umbral de los niveles HOMA-IR para definir IR, 25 así pues se sugiere precaución al interpretar los índices de evaluación de RI en estas pacientes, 26 considerando de utilidad para el diagnóstico el índice de Belfiori. 27 Síndrome de Insulina Autoinmune (SIA): Aunque raro, se presenta con mayor frecuencia en asiáticos, se caracteriza por hipoglicemia hiperinsulinémica, títulos elevados de anticuerpos antiinsulina en un individuo, no expuesto a insulina exógena y, sin anormalidad patológica en las células de los islotes pancreáticos; reconocida como Enfermedad de Hirata (EH) y descrita en 1970 asociada a exposición a virus o fármacos en la mitad de los casos.…”

Section: Manifestaciones Clínicasunclassified

Resistencia a Insulina: Revisión de literatura

Lozano¹

2022

Rev Méd Hondur

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La resistencia a la insulina es una condición patológica de expresión variable asociada a riesgo cardiovascular, diabetes mellitus tipo 2, hígado graso de etiología no alcohólica, lipodistrofias, síndrome de ovario poliquístico y algunos cánceres. El propósito de esta revisión bibliográfica es brindar información actualizada al lector sobre algunos de los avances actuales de la resistencia a la insulina. Se realizó una búsqueda de literatura en PUBMED de enero 2014-octubre 2021, obteniéndose 1,354 referencias, seleccionando 39 publicaciones. Aunque continúe la discusión sobre la definición clínica y laboratorial, se ha determinado que el manejo terapéutico y preventivo para casos de resistencia a la insulina se debe basar en cambios de estilo de vida con apoyo farmacológico individualizado. El impacto actual y potencial en el futuro inmediato de la epidemiología de la resistencia a la insulina está en los estudios clínico-terapéuticos en curso y en las políticas públicas dirigidas a fomentar el estilo de vida saludable.

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“… 1 , 2 PCOS was found to be associated with different diseases such as metabolic syndrome, type 2 diabetes, hypertension, cardiovascular diseases and even ovulatory infertility. 3 , 4 There are four distinguished subtypes; inflammatory, hidden cause and finally, pill‐induced PCOS and insulin‐resistant (the most prevalent type). 5 , 6 Although the complete etiology of the syndrome remains unclear, the genetic, epigenetic, environmental factors and lifestyle have been associated with PCOS causality.…”

Section: Introductionmentioning

confidence: 99%

microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome

Tamaddon

Azimzadeh

Tavangar

2022

J Cellular Molecular Medi

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Polycystic ovary syndrome (PCOS) is known as the most common endocrine/metabolic disorder in women of reproductive age, where it is reported that PCOS affects 5 to 26 percent of women (based on the applied diagnostic criteria) around the world. 1,2 PCOS was found to be associated with different diseases such as metabolic syndrome, type 2 diabetes, hypertension, cardiovascular diseases and even ovulatory infertility. 3,4 There are four distinguished subtypes; inflammatory, hidden cause and finally, pill-induced PCOS and insulin-resistant (the most prevalent type). 5,6 Although the complete etiology of the syndrome remains unclear, the genetic, epigenetic, environmental factors and lifestyle have been associated with PCOS causality. In clinical and/or biochemical settings, diagnosis is based on whether the patient shows no less than two out of three main symptoms, including cysts in the ovaries, high androgen levels and irregular periods. Despite the controversial opinions of current diagnostic criteria of PCOS, an expert opinion from the ultrasound, pelvic exam and blood tests can confirm the diagnosis. 7,8 Blood tests for PCOS are mainly based on hormone levels and endocrine function,

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The role of miRNAs in polycystic ovary syndrome with insulin resistance

Cited by 21 publications

References 196 publications

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Resistencia a Insulina: Revisión de literatura

microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome

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