The role of miRNAs in insulin resistance and diabetic macrovascular complications – A review

Mageed, Sherif S. Abdel; Doghish, Ahmed S.; Ismail, Ahmed; El-Husseiny, Ahmed A.; Fawzi, Sylvia F; Mahmoud, Abdulla M.A.; El-Mahdy, Hesham A.

doi:10.1016/j.ijbiomac.2023.123189

Cited by 64 publications

(7 citation statements)

References 95 publications

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“…The interface between miRNA and myocardial energy remodelling can be seen in substrate uptake, preference and energy production, which includes FAO, the TCA cycle and electron transport chain (ETC) activity. 61 Glucose transporter protein 4 (GLUT4), the major carrier of glucose sugars for muscle uptake, is downregulated in HFpEF. 62 miR-200a-5p contributes to impaired glucose metabolism by regulating selenoproteins that regulate glucose transportrelated molecules such as GLUT4.…”

Section: Mirnas In Energy Metabolism Abnormalitiesmentioning

confidence: 99%

“…Cardiomyocytes undergo metabolic remodelling to adapt to changes in the metabolic environment associated with metabolic syndrome. The interface between miRNA and myocardial energy remodelling can be seen in substrate uptake, preference and energy production, which includes FAO, the TCA cycle and electron transport chain (ETC) activity 61 . Glucose transporter protein 4 (GLUT4), the major carrier of glucose sugars for muscle uptake, is downregulated in HFpEF 62 .…”

Section: The Role Of Mirnas In the Pathophysiology Of Hfpefmentioning

confidence: 99%

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Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs

Li,

Sun,

Wang

et al. 2023

Eur J Clin Investigation

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BackgroundHeart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with a complex aetiology commonly associated with comorbidities such as diabetes mellitus, obesity, hypertension and renal disease. Various diseases induce systemic, chronic and low‐grade inflammation; microvascular dysfunction; metabolic stress; tissue ischemia; and fibrosis, leading to HFpEF. An effective treatment for HFpEF is lacking, largely owing to its pathophysiological heterogeneity. Recent studies have revealed that microRNAs (miRNAs) play crucial roles in regulating the pathogenesis of HFpEF and its comorbidities.MethodsThis narrative review included original articles and reviews published over the past 20 years found through ‘PubMed’ and ‘Web of Science’. The search terms included “HFpEF,” “MicroRNAs,” “comorbidities,” “Microvascular Dysfunction (MVD),” “inflammation,” “pathophysiology,” “endothelial dysfunction,” “energy metabolism abnormalities” “cardiac fibrosis” and “treatment.”ResultsInflammation, MVD, abnormal energy metabolism, myocardial hypertrophy and myocardial fibrosis are important pathophysiological mechanisms underlying HFpEF. As gene expression regulators, miRNAs may contribute to the pathophysiology of HFpEF and are expected to serve in the stratification of patients with HFpEF and as prognostic indicators for monitoring treatment responses.ConclusionsA customized strategy based on miRNAs has emerged as an effective treatment for HFpEF. In this review, we discuss recent research surrounding miRNAs and HFpEF and propose potential miRNA targets for the pathophysiology of HFpEF and its comorbidities. Although current research concerning miRNAs and their therapeutic potential is in its early stages, miRNA‐based diagnostics and therapeutics hold great promise in the future.

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Section: Mirnas In Energy Metabolism Abnormalitiesmentioning

confidence: 99%

Section: The Role Of Mirnas In the Pathophysiology Of Hfpefmentioning

confidence: 99%

Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs

Li,

Sun,

Wang

et al. 2023

Eur J Clin Investigation

View full text Add to dashboard Cite

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“…Insulin (INS) remains the only effective drug for controlling blood glucose levels in patients with insufficient INS secretion diabetes, which causes devastating macrovascular complications (cardiovascular disease) and microvascular complications ( e.g ., diabetic nephropathy, retinopathy, and neuropathy), impacting nearly 10.5% (537 million people) of the whole population. − Frequent subcutaneous injections of insulin are essential to attaining normoglycemia in patients with type 1 or advanced type 2 diabetes. However, this method often results in poor patient compliance and unavoidable physical and mental suffering. , Therefore, noninvasive routes are under intensive investigation. − Oral administration of insulin is considered to be the most advantageous therapy to mimic endogenous insulin secretion by establishing a physiological gradient of portal–peripheral insulin .…”

Section: Introductionmentioning

confidence: 99%

Template-Free Self-Assembly of Hollow Microtubular Covalent Organic Frameworks for Oral Delivery of Insulin

Dai,

Wu,

Xiao

et al. 2024

ACS Appl. Mater. Interfaces

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Covalent organic frameworks (COFs) have demonstrated versatile application potential since their discovery. Although the structure of COFs is orderly arranged, the synthesis of controllable macrostructures still faces challenges. Herein, we report, to our knowledge, the first template-free selfassembled COF-18 Å hollow microtubule (MT-COF-18 Å) structure and its use for insulin delivery that exhibits high loading capacity, gastroresistance, and glucose-responsive properties. The hollow MT-COF-18 Å was achieved by a template-free method benefiting from the mixed solvents of mesitylene and dioxane. The formation mechanism and morphology changes with insulin loading and release were observed. In Caco-2 cells, the transferrin-coated system demonstrated enhanced insulin cellular uptake and transcellular transport, which indicated great potential for oral applications. Additionally, the composites presented sustained glycemic control and effective insulin blood concentrations without noticeable toxicity in diabetic rats. This work shows that hollow microtubular COFs hold great promise in loading and delivery of biomolecules.

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“…Noncoding RNAs (ncRNAs) are RNA transcripts that encode noncoding sequences of the human genome and are divided into particular types related to their length and structure. It is now well documented that ncRNAs including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) can influence many processes that contribute to multiple diseases, including cancers (5,6), liver diseases (7,8), bone diseases (9,10), multiple myeloma (11,12), cardiovascular diseases (13,14), rheumatoid arthritis (15,16), diabetes (17,18), obesity and metabolic syndrome (19,20) .…”

Section: Introductionmentioning

confidence: 99%

The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer

El-Husseiny,

Ali,

Fakhry

2024

ERU Research Journal

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Esophageal cancer (EC) is the 2nd fatal gastrointestinal tract malignancy and the sixth most predominant driver of cancer-associated mortality worldwide. Interestingly, long non-coding RNAs (lncRNAs) have a sequence of more than 200 base pairs and are regarded as one of the epigenetic elements. LncRNAs have been demonstrated to influence EC features comprising initiation, development, angiogenesis, invasion, and metastasis. Notably, lncRNAs could modulate the expression of several genes and chromatin architectures which are implicated in EC pathogenesis.Besides, numerous lncRNAs have a crucial role in the chemotherapeutic response of EC cells.Furthermore, lncRNAs are thought to be a promising biomarker in EC whose expression patterns can distinguish between EC subtypes and stages as well as predict cancer aggressiveness. Thus, the ERURJ 2024, x, x, 1-27, accepted 2 current review emphasizes the latest updates on the modulatory functions of lncRNAs in EC pathogenesis, their significance to the EC cells' therapeutic response, and their clinical efficacy as prognostic and diagnostic biomarkers.

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The role of miRNAs in insulin resistance and diabetic macrovascular complications – A review

Cited by 64 publications

References 95 publications

Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs

Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs

Template-Free Self-Assembly of Hollow Microtubular Covalent Organic Frameworks for Oral Delivery of Insulin

The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer

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