Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs
Xiaonan Li,
Min Sun,
Zhe Wang
et al.
Abstract:BackgroundHeart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with a complex aetiology commonly associated with comorbidities such as diabetes mellitus, obesity, hypertension and renal disease. Various diseases induce systemic, chronic and low‐grade inflammation; microvascular dysfunction; metabolic stress; tissue ischemia; and fibrosis, leading to HFpEF. An effective treatment for HFpEF is lacking, largely owing to its pathophysiological heterogeneity. Recent studies have reveale… Show more
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