The role of miRNAs as biomarkers in prostate cancer

Cózar, J.M.; Robles-Fernández, Inmaculada; Rodríguez–Martínez, A.; Puche-Sanz, Ignacio; Vázquez-Alonso, Fernando; Lorente, José A.; Martínez-González, Luis Javier; Álvarez-Cubero, María Jesús

doi:10.1016/j.mrrev.2019.05.005

Cited by 37 publications

(27 citation statements)

References 132 publications

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“…Many miRNAs are known to be involved in oncogenesis, tumor progression, and metastasis by targeting tumor suppressors, oncogenes, or other proteins associated with disease progression or drug resistance [4][5][6][7][8]. Differential expression of miRNAs in biological fluids of patients with different cancers and healthy donors has been previously reported by many groups [7,[9][10][11][12][13][14][15]. Other reports also showed extracellular vesicles (EVs) and cell-free nucleoprotein complexes carry distinct populations of miRNA, and the content of these miRNA pools can be used to develop promising tools for PCa screening [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Panel of 12 Cell-Free MicroRNAs as Potential Biomarkers in Prostate Neoplasms

et al. 2020

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Prostate cancer is a global biological, medical, and social issue aggravated by the lack of reliable, highly specific, and sensitive non-invasive tests for diagnosis and staging of prostate cancer. One prospective source of biomarkers are the cell-free miRNAs present in various biological fluids. In the present study, we validated the diagnostic potential of cell-free miRNAs: miR-19b, miR-22, miR-92a, miR-378, miR-425, miR-30e, miR-31, miR-125b, miR-200b, miR-205, miR-375, and miR-660; we estimated the required sample size and the minimal miRNA set for a subsequent large-scale validation study. Relative expression of 12 miRNA combined in 31 ratios was investigated in three fractions of biological fluids (urine extracellular vesicles, clarified urine, and plasma) obtained from patients with prostate cancer (n = 10), benign prostate hyperplasia (n = 8), and healthy volunteers (n = 11). Eight of the miRNAs found in urine vesicles (miR-19b, miR-30e, miR-31, miR-92a, miR-125, miR-200, miR-205, and miR-660) showed great promise and when combined into six ratios (miR-125b/miR-30e, miR-200/miR-30e, miR-205/miR-30e, miR-31/miR-30e, miR-660/miR-30e, and miR-19b/miR-92a) could classify patients with prostate cancer, benign prostate hyperplasia, and healthy donors with 100% specificity, 100% sensitivity, and with a high degree of reliability for most donors.

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Section: Introductionmentioning

confidence: 99%

The Panel of 12 Cell-Free MicroRNAs as Potential Biomarkers in Prostate Neoplasms

et al. 2020

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“…In addition, there are other prognostic biomarkers based on SNP panels or epigenetic modifications. However, the current tools are either invasive procedures or have a relatively high negative predictive value [37]. In recent years, the overall mortality rates of prostate cancer have actually declined, particularly in developed countries, due to successful diagnosis and treatment [38], which indicates the importance of early-stage diagnosis of prostate cancer as well as the screening of PCa with high metastatic potential.…”

Section: Discussionmentioning

confidence: 99%

EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis

Zhang

Wang

et al. 2021

Molecular Oncology

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Early and accurate diagnosis of prostate cancer (PCa) is extremely important, as metastatic PCa remains hard to treat. EWI-2, a member of the Ig protein subfamily, is known to inhibit PCa cell migration. In this study, we found that EWI-2 localized on both the cell membrane and exosomes regulates the distribution of miR-3934-5p between cells and exosomes. Interestingly, we observed that EWI-2 is localized not only on the plasma membrane but also on the nuclear envelope (nuclear membrane), where it regulates the nuclear translocation of signaling molecules and miRNA. Collectively, these functions of EWI-2 found in lipid bilayers appear to regulate PCa cell metastasis through the epidermal growth factor receptor-mitogen-activated protein kinase-extracellular-signal-regulated kinase (EGFR-MAPK-ERK) pathway. Our research provides new insights into the molecular function of EWI-2 on PCa metastasis, and highlights EWI-2 as a potential PCa biomarker.

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“…As non‐classical transcriptional products, circular RNAs are synthesized in the nucleus and mature in the cytoplasm 25,26 . circRNAs act as microRNA sponges by forming circRNA/miRNA complexes at specific binding sites 27 .…”

Section: Discussionmentioning

confidence: 99%

circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR‐1225/PKN2 axis

Tang

Zou

et al. 2020

J Cellular Molecular Medi

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Circular RNAs (circRNAs) represent a newly discovered class of endogenous non‐coding RNAs which are widely expressed and play important roles in disease progression. However, the function of circRNAs in oral squamous cell carcinoma (OSCC) still remains largely unknown. In this research, we found that circ_SEPT9 was highly expressed in OSCC cell lines and tumour tissues. Results showed that circ_SEPT9 promoted OSCC proliferation and tumour growth. And, circ_SEPT9 also enhanced the migration and invasion of OSCC cells. Mechanically, we found that circ_SEPT9 acted as a sponge for miR‐1225 to rescue PKN2 expression in OSCC cells. Inhibition of circ_SEPT9/miR‐1225/PKN2 pathway could effectively block the proliferation and metastasis of OSCC cells. Our study provides strong evidence that circ_SEPT9/miR‐1225/PKN2 axis is a promising target for OSCC treatment.

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The role of miRNAs as biomarkers in prostate cancer

Cited by 37 publications

References 132 publications

The Panel of 12 Cell-Free MicroRNAs as Potential Biomarkers in Prostate Neoplasms

The Panel of 12 Cell-Free MicroRNAs as Potential Biomarkers in Prostate Neoplasms

EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis

circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR‐1225/PKN2 axis

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