The Role of miR‐21 in Cancer

Pfeffer, Susan R.; Yang, Chuan; Pfeffer, Lawrence M.

doi:10.1002/ddr.21257

Cited by 283 publications

(227 citation statements)

References 68 publications

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“…[38] miR-21 may serve as a key regulator of oncogenic processes, including tumor growth, migration, and invasion. [39] Elevated miR-21 expression levels have been found to be associated with poor outcomes in cancer patients.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs in the prognosis of triple-negative breast cancer

Mao

Shi

et al. 2017

Medicine

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Background:Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors characterized by their aggressive nature and poor associated survival. MicroRNAs (miRs) have been found to play an important role in the occurrence and development of human cancers, but their role in the prognosis of TNBC patients remains unclear. We performed a meta-analysis to explore the prognostic value of miRs in TNBC.Methods:We systematically searched the PubMed, Embase, and Web of Science databases to identify eligible studies. A meta-analysis was performed to estimate the pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) for the associations between levels of miR expression (predictive factors) and overall survival (OS) and disease-free survival (DFS) (outcomes) in patients with TNBC.Results:After performing the literature search and review, 21 relevant studies including 2510 subjects were identified. Six miRs (miR-155, miR-21, miR-27a/b, miR-374a/b, miR-210, and miR-454) were assessed in the meta-analysis. Decreased expression of miR-155 was associated with reduced OS (adjusted HR = 0.58, 95% CI: 0.34–0.99; crude HR = 0.67, 95% CI: 0.58–0.79). High miR-21 expression was also predictive of reduced OS (crude HR = 2.50, 95% CI: 1.56–4.01). We found that elevated levels of miR-27a/b, miR-210, and miR-454 expression were associated with shorter OS, while the levels of miR-454 and miR-374a/b expression were associated with DFS.Conclusions:Specific miRs could serve as potential prognostic biomarkers in TNBC. Due to the limited research available, the clinical application of these findings has yet to be verified.

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Section: Discussionmentioning

confidence: 99%

MicroRNAs in the prognosis of triple-negative breast cancer

Mao

Shi

et al. 2017

Medicine

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“…Previous evidence indicates that miR-21 participates in the development and progression of various types of human tumors, including glioblastoma, hepatocellular, lung, colon, and prostate cancer (15,16). miR-21 is encoded by chromosome 17q23.2, which is frequently involved in unbalanced translocations in NB cell lines (15).…”

Section: Discussionmentioning

confidence: 99%

Reduction of miR-21 induces SK-N-SH cell apoptosis and inhibits proliferation via PTEN/PDCD4

Wang

Yao

et al. 2017

Oncology Letters

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MicroRNA (miR/miRNA)-21 is a well-known oncogenic miRNA that is overexpressed in various types of tumors. The tumor-suppressor genes programmed cell death 4 (PDCD4) and phosphatase tensin homologue (PTEN), are targets of miR-21, and are underexpressed in several types of cancer. However, the expression of miR-21 and its target genes in neuroblastoma (NB) remains unclear. In the present study, a miR-21 inhibitor oligonucleotide was transfected into the SK-N-SH cell line, and the expression of miR-21, PTEN and PDCD4 was detected through quantitative polymerase chain reaction analysis. Western blotting was used to examine levels of PTEN, PDCD4 and caspase-3 proteins. The expression of PTEN and PDCD4 in the SK-N-SH cell line transfected with the miR-21 inhibitor was significantly increased compared with untransfected SK-N-SH and negative control-transfected cells. Cell proliferation was inhibited and the apoptotic ratio was significantly increased in miR-21 inhibitor-transfected cells compared with untransfected SK-N-SH and negative control-transfected cells. Western blot analysis revealed a significant increase in caspase-3 expression compared with untransfected SK-N-SH and negative control-transfected cells. The results of the present study indicate that miR-21 may serve an oncogenic role in the cellular processes underlying NB development and thus may be a novel therapeutic target for the treatment of patients with NB.

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“…By their up-regulation, onco-miRNAs negatively modulate the expression of tumor suppressor genes, while the down-regulation of TS-miRNAs will result in the absence of regulation or increased expression of oncogenes. A selection of oncomiRs and tumor-suppressor miRNAs, their mRNA targets as well as the pathologies where they are involved are presented in MiR-21, one of the most oncogenic miRNAs, is frequently overexpressed in many tumor types [33] including cervical cancer cells [34]. MiR-21 can down-regulate multiple tumor suppressor genes such as phosphatase and tensin homolog (PTEN), B-cell lymphoma protein 2 (BCL2), programmed cell death 4 (PDCD4), BTG2 or tropomyosin 2 (TPM2), leading to cell survival, increased proliferation and decreased apoptosis [35,36].…”

Section: Mirnas Can Function As Oncogenes or Tumor Suppressor Genesmentioning

confidence: 99%

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

Bălăcescu¹,

Bălăcescu²,

Baldasici³

et al. 2017

Colposcopy and Cervical Pathology

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Cervical cancer represents one of the major problems of health women worldwide, especially in the developing countries. If discovered in its earliest stages, cervical cancer is successfully treatable; however, due to lack of proper implementation of screening programs, the majority of cervical cancer patients are diagnosed in advanced stages, which dramatically influence their outcome. Almost a half of these patients will suffer recurrence or metastasis in the following 2 years after therapy. If there are no immediate prospects in terms of developing new or more effective therapies, identifying new tools for early diagnosis, prognosis and treatment prediction remains a big challenge for cervical cancer. miRNAs have been validated to be key players in cell physiology, alterations in miRNA expression being associated with cancer progression and response to therapy. Cervical cancer studies have showed that alterations of miRNA expression can be identified in tumor tissues, exfoliated cervical cells and patients serum and that their transcription pattern is regulated by the present HPV genotype. Furthermore, miRNAs have been associated with patients response to therapy, therefore suggesting their potential to be used as biomarkers for cervical cancer diagnosis, prognosis and treatment response.

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The Role of miR‐21 in Cancer

Cited by 283 publications

References 68 publications

MicroRNAs in the prognosis of triple-negative breast cancer

MicroRNAs in the prognosis of triple-negative breast cancer

Reduction of miR-21 induces SK-N-SH cell apoptosis and inhibits proliferation via PTEN/PDCD4

The Role of miRNAs in Diagnosis, Prognosis and Treatment Prediction in Cervical Cancer

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