The role of miR-130a in cancer

Zhang, Heda; Jiang, Linhong; Sun, Dawei; Li, Jian; Ji, Zhenling

doi:10.1007/s12282-017-0776-x

Cited by 89 publications

(68 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, of the 13 miRNAs included in our signature, there is limited evidence regarding the role of hsa-miR-125-5p in breast cancer progression, while there is some evidence to suggest that miR-301-5p stimulates proliferation and invasion (26) and that hsa-miR-196-5p and hsa-miR-340-5p inhibit progression (27,28). For hsa-miR-30-5p, hsa-miR-130-5p, hsa-miR-93-5p, hsa-miR-503-5p, and hsa-miR-205-5p, there is conflicting evidence regarding their roles in breast cancer progression, with some reports suggesting functions that operate to increase the risk of progression and others suggesting the reverse (29)(30)(31)(32)(33)(34)(35). The apparently conflicting evidence regarding the roles of specific miRNAs in breast cancer prognosis is consistent with the observation that some miRNAs exert both oncogenic and tumor suppressive effects (36,37).…”

Section: Discussionmentioning

confidence: 99%

A miRNA Expression Signature in Breast Tumor Tissue Is Associated with Risk of Distant Metastasis

et al. 2019

View full text Add to dashboard Cite

Dysregulation of miRNA expression may influence breast cancer progression, and experimental evidence suggests that miRNA silencing might suppress breast cancer metastasis. However, the relationship between miRNA and metastasis must be confirmed before this approach can be applied in the clinic. To this end, we conducted a two-stage study in a cohort of 3,760 patients with breast cancer to first identify and then validate the association between miRNA expression and risk of distant metastasis. The first stage (discovery) entailed miRNA sequencing of 126 casecontrol pairs; qPCR was used to validate the findings in a separate set of 80 case-control pairs. The 13 miRNAs most differentially expressed between cases and controls were combined into an miRNA score that was significantly associated with risk of distant metastasis in a logistic regression model that also included clinical variables (tumor size and number of positive lymph nodes) (OR per unit increase in score ¼ 1.30; 95% confidence interval, 1.03-1.66). The results of this study suggest that in women with invasive breast cancer, a miRNA score that incorporates both clinical variables and miRNA expression levels in breast tumor tissue is moderately predictive of risk of subsequent distant metastasis.Significance: A novel predictive scoring system for patients with breast cancer includes clinical variables and the expression levels of 13 miRNAs and may help to identify those at increased risk of distant metastasis. Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): T.E. Rohan, S. Weinmann, O. Loudig Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis):

show abstract

Section: Discussionmentioning

confidence: 99%

A miRNA Expression Signature in Breast Tumor Tissue Is Associated with Risk of Distant Metastasis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…miR-130a has recently been demonstrated to be involved in various common human cancer types, including hepatocellular carcinoma, ovarian cancer, glioblastoma, prostate carcinoma, leukemia and cervical cancer (15). Feng et al (16) reported that miR-130a was regulated by nuclear factor (NF)-κB and promoted cervical cancer cell growth by inhibiting the expression of phosphatase and tensin homolog (PTEN).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2

et al. 2019

View full text Add to dashboard Cite

Human papillomaviruses (HPVs) have important roles in the development and progression of cervical cancer, but the underlying mechanisms are yet to be fully elucidated. MicroRNA-130a (miR-130a) has previously been reported to promote cervical cancer growth. However, the underlying molecular mechanisms by which miR-130a promotes cervical cancer progression have remained largely elusive. In the present study, polymerase chain reaction and western blot analyses were performed to examine the expression levels of miR-130a and associated proteins. A wound healing assay and a Transwell assay were applied to study cell migration and invasion. A luciferase reporter gene assay was performed to confirm the targeting associations of miR-130a. It was observed that miR-130a was significantly upregulated in cervical cancer tissues compared with that in adjacent non-tumorous tissues. High expression of miR-130a was significantly associated with lymph node metastasis and an advanced clinical stage of cervical cancer. Furthermore, the expression of miR-130a was also higher in HPV(+) cervical cancer cell lines compared with that in HPV(-) cells. Knockdown of HPV18 E6 significantly inhibited the expression of miR-130a in HeLa cervical cancer cells. Furthermore, knockdown of miR-130a reduced the migration and invasion of HeLa cells. Tissue inhibitor of metalloproteinase 2 (TIMP2), an antagonist of matrix metalloproteinase 2 (MMP2), was identified as a novel, direct target gene of miR-130a. The expression of TIMP2 was negatively mediated by miR-130a, and HPV18 E6 inhibited the expression of TIMP2 in HeLa cells. Furthermore, knockdown of TIMP2 rescued the suppressive effects of miR-130a downregulation on the migration and invasion of HeLa cells. In summary, the present study suggests that HPV18 E6 promotes the expression of miR-130a, which further inhibits the expression of TIMP2 and promotes cervical cancer cell invasion. Therefore, HPV/miR-130a/TIMP2 signaling may be a potential target for the prevention of cervical cancer metastasis.

show abstract

“…Both micro-RNAs are involved in cancer. In particular, upregulation of miR-135b promotes chemoresistance (23) and cancer progression (24) in colorectal cancer, whereas miR-130a is associated with drug resistance and acts as an intermediate in the Wnt/b-catenin pathway (25). More importantly, both microRNAs were shown to downregulate KLF4 expression (26), supporting the idea that their decreased expression plays an important role in the 5-ASA-mediated increase in KLF4 expression.…”

Section: Discussionmentioning

confidence: 84%

KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells

Parenti

Montorsi

Fantini

et al. 2018

Cancer Prevention Research

View full text Add to dashboard Cite

Mesalazine (5-ASA) is an aminosalicylate anti-inflammatory drug capable of inducing μ-protocadherin, a protein expressed by colorectal epithelial cells that is downregulated upon malignant transformation. Treatment with 5-ASA restores μ-protocadherin expression and promotes the sequestration of β-catenin to the plasma membrane. Here, we show that 5-ASA-induced μ-protocadherin expression is directly regulated by the KLF4 transcription factor. In addition, we suggest the existence of a dual mechanism whereby 5-ASA-mediated β-catenin inhibition is caused by μ-protocadherin-dependent sequestration of β-catenin to the plasma membrane and by the direct binding of KLF4 to β-catenin. In addition, we found that 5-ASA treatment suppresses the expression of miR-130a and miR-135b, which target KLF4 mRNA, raising the possibility that this mechanism is involved in the increased expression of KLF4 induced by 5-ASA. .

show abstract

The role of miR-130a in cancer

Cited by 89 publications

References 63 publications

A miRNA Expression Signature in Breast Tumor Tissue Is Associated with Risk of Distant Metastasis

A miRNA Expression Signature in Breast Tumor Tissue Is Associated with Risk of Distant Metastasis

MicroRNA‑130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2

KLF4 Mediates the Effect of 5-ASA on the β-Catenin Pathway in Colon Cancer Cells

Contact Info

Product

Resources

About