The Role of Microsatellites as a Prognostic Factor in Primary Malignant Melanoma

Shaikh, Ladan; Sagebiel, Richard W.; Ferreira, Carlos; Nosrati, Mehdi; Miller, James R.; Kashani‐Sabet, Mohammed

doi:10.1001/archderm.141.6.739

Cited by 57 publications

(32 citation statements)

References 21 publications

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“…Some authors acclaimed that microsatellites predict locoregional relapse but not overall survival (Shaikh et al, 2005). Acording to a recent study, SLN positivity rate was 43 % in microsatellite patients (Bartlett et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ≥6/mm 2 mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The presence of microsatellites is closely associated with thickness and Clark’s level (both of which are important prognostic factors [4]) and contributes to the ability to predict locoregional relapse and relapse-free survival [12]. Poor documentation of this feature may be due to lack of report of absence of the feature.…”

Section: Discussionmentioning

confidence: 99%

Completeness of Histopathology Reporting of Melanoma in a High-Incidence Geographical Region

et al. 2008

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Background: Appropriate histopathology reporting helps to ensure effective therapy and prognosis. Objective: Toexamine compliance with clinical practice guidelines for histopathology reports of melanomas. Methods: A sample of melanoma histopathology reports in Queensland was audited for inclusion of recommended information. The quality of documentation was constructed and multivariate analysis used to determine factors affecting the quality of reporting practices. Results: Documentation of the most important features of melanoma was high: clear diagnosis (99.8%; 95% CI 98.6–100), thickness (99.8%; 95% CI 98.6–100), comment on adequacy of excision (87.9%; 95% CI 84.9–91.0) and measurement of margins (91.9%; 95% CI 88.8–91.4). Overall reporting of ulceration and regression was of lesser completeness (83.0 and 77.8%, respectively) and these features were more likely to be reported by high-volume laboratories (p < 0.001 and p = 0.037, respectively). This trend was not apparent for other features. Fewer than 50% of reports documented mitotic rate per square millimetre, predominant cell type, microsatellites, growth phase and desmoplasia. Conclusion: Awareness of current reporting practices and identification of areas in which insufficiencies exist enable the revision of systems and potential improvements to the transfer of information to treating clinicians.

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“…melanoma according to the 2010 AJCC staging criteria and therefore must also be reported. 27,37,[42][43][44] There is evidence that several other histologic features of a primary melanoma provide prognostic value, including the presence or absence of a vertical growth phase, tumor-infiltrating lymphocytes, dermal regression, and angiolymphatic invasion. 21,23,27,33,35,37,38,[45][46][47][48] Although not essential, the expert work group recommends that these histologic characteristics are included as optional elements of the pathology report.…”

Section: Nxmentioning

confidence: 99%