The Role of MicroRNAs in Chemoresistance

Bahreini, Farbod; Rezaei, Nima

doi:10.1007/978-3-030-80962-1_336-1

Cited by 43 publications

(1 citation statement)

References 187 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, more and more research focus on oncogene [40], epigenetic dysregulation [41] and miRNA abnormal expression [42,43] in drug resistance. In addition, miRNA microarray or RT-qPCR array analysis identi ed different miRNAs as DDP resistance-related genes [44][45][46][47].…”

Section: Silenced Mir-6838-5p Motivates the Metastasis And Ddp Resist...mentioning

confidence: 99%

MicroRNA-6838-5p suppresses metastasis and increases cisplatin sensitivity in lung cancer

Zhu²,

Zhu

et al. 2023

Preprint

View full text Add to dashboard Cite

Cisplatin (DDP) chemotherapy is effective to treat tumors but potentially limited to drug resistance. The research studied miR-6838-5p in controlling LC cells’ DDP resistance. First, clinical samples of DDP-resistant LC and DDP-sensitive LC were obtained and clinicopathological information was analyzed. Then, a DDP-resistant cell model (A549/DDP) was established and transfected with the plasmid vector that interfered with the expression of miR-6838-5p or SYPL1. Cell viability and half-maximal inhibitory concentration (IC50), apoptosis, migration and invasion were detected by CCK-8, flow cytometry, and Transwell, respectively. miR-6838-5p, SYPL1, MMP-2 and MMP-9 expression was determined by RT-qPCR or immunoblot analysis. Finally, the targeting relationship between miR-6838-5p and SYPL1 was verified by bioinformatics website and luciferase reporter assay. Experiment result showed that reduced miR-6838-5p and upregulated SYPL1 were presented in DDP-resistant LC. Elevating miR-6838-5p or suppressing SYPL1 repressed proliferative, migratory, and invasive activities and DDP resistance, but promoted apoptosis in A549/DDP cells. MiR-6838-5p targeted SYPL1. Moreover, SYPL1 overexpression turned around elevated miR-6838-5p-mediated effect on A549/DDP metastasis and DDP resistance. In conclusion, miR-6838-5p targets SYPL1 to restrain metastasis and DDP resistance of LC cells.

show abstract

Section: Silenced Mir-6838-5p Motivates the Metastasis And Ddp Resist...mentioning

confidence: 99%

MicroRNA-6838-5p suppresses metastasis and increases cisplatin sensitivity in lung cancer

Zhu²,

Zhu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update

Torki

Ghavi

Hashemi

et al. 2021

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

MiR-221/222 promote chemoresistance to cisplatin in ovarian cancer cells by targeting PTEN/PI3K/AKT signaling pathway

et al. 2017

View full text Add to dashboard Cite

Cisplatin resistance is one of the main limitations in the treatment of ovarian cancer, and its mechanism has not been fully understood. The objectives of this study were to determine the role of miR-221/222 and its underlying mechanism in chemoresistance of ovarian cancer. We demonstrated that miR-221/222 expression levels were higher in A2780/CP cells compared with A2780 S cells. An in vitro cell viability assay showed that downregulation of miR-221/222 sensitized A2780/CP cells to cisplatin-induced cytotoxicity. Moreover, we found that knockdown of miR-221/222 by its specific inhibitors promoted the cisplatin-induced apoptosis in A2780/CP cells. Using bioinformatic analysis and luciferase reporter assay, miR-221/222 were found to directly target PTEN. Moreover, knockdown of miR-221/222 in A2780/CP cells significantly upregulated PTEN and downregulated PI3KCA and p-Akt expression. In conclusion, our results demonstrated that miR-221/222 induced cisplatin resistance by targeting PTEN mediated PI3K/Akt pathway in A2780/CP cells, suggesting that miR-221/222/PTEN/PI3K/Akt may be a promising prognostic and therapeutic target to overcome cisplatin resistance and treat ovarian cancer in the future.

show abstract

The Role of MicroRNAs in Chemoresistance

Cited by 43 publications

References 187 publications

MicroRNA-6838-5p suppresses metastasis and increases cisplatin sensitivity in lung cancer

MicroRNA-6838-5p suppresses metastasis and increases cisplatin sensitivity in lung cancer

The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update

MiR-221/222 promote chemoresistance to cisplatin in ovarian cancer cells by targeting PTEN/PI3K/AKT signaling pathway

Contact Info

Product

Resources

About