Abstract:Cisplatin (DDP) chemotherapy is effective to treat tumors but potentially limited to drug resistance. The research studied miR-6838-5p in controlling LC cells’ DDP resistance. First, clinical samples of DDP-resistant LC and DDP-sensitive LC were obtained and clinicopathological information was analyzed. Then, a DDP-resistant cell model (A549/DDP) was established and transfected with the plasmid vector that interfered with the expression of miR-6838-5p or SYPL1. Cell viability and half-maximal inhibitory concen… Show more
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