The Role of Manganese Superoxide Dismutase in Inflammation Defense

Li, Chang; Zhou, Hai‐Meng

doi:10.4061/2011/387176

Cited by 100 publications

(89 citation statements)

References 51 publications

(52 reference statements)

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“…It means that SOD content in FFS operators were used to avoid free radical as a result of FFS oxidant exposure. This result was still in line with the theory that oxidant exposure could cause the decrease of endogen antioxidant [5,6,15,16].…”

Section: Resultssupporting

confidence: 80%

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Superoxide Dismutase Levels of Operator Gas Stations in Semarang, Central Java, Indonesia.

Dewi

Yuniastuti²

2017

KLS

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Air pollutants exposure on the gas station generally comes from motor vehicle emissions, such as toluene, benzene, xylene or polycyclic aromatic hydrocarbons (PAH) compounds. These compounds are metabolized by the liver to form free radicals, thus are harmful to health. Gas station operators have a substantial risk of air pollutants exposure released by motor vehicle emissions. The objective of this research is to find out the levels of superoxide dismutase (SOD) in gas station operator on Semarang, Indonesia. This research was analytic observational cross-sectional study conducted from April to August 2015. The number of samples obtained in this research was 21 gas station operators and 10 volunteers who live in the countryside. Blood SOD levels biochemically determined using Randox kit SOD. The results showed that the average of SOD level in gas station operators was 0.76 u ⋅ mL −1 and volunteers was 0.87 u ⋅ mL −1 . Statistical test results of SOD levels showed the significant value p = 0.860. The SOD levels of gas stations operators are lower than the SOD levels of volunteers who live in the countryside. Gas stations operator does not significantly influence SOD levels.Keywords: gas station operators, pollutants, superoxide dismutase. Nomenclature

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Section: Resultssupporting

confidence: 80%

“…Free radical oxides macromolecule in the body such as fat, protein and nucleate acid, causes cell damage. High and long exposure by oxidant can cause free radical accumulation, cell damage and health disorder [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase Levels of Operator Gas Stations in Semarang, Central Java, Indonesia.

Dewi

Yuniastuti²

2017

KLS

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“…Mn-SOD can scavenge O2 *-and therefore mimics anti-inflammatory agent. Altered Mn-SOD levels and chronic inflammation have been associated with neurodegenerative diseases (Li and Zhou, 2011), metabolic diseases, and liver diseases (Kitada et al, 2011). Additionally, Mn-SOD participates in the mitochondrial repair processes and has a role along with p53 in preventing mitochondrial DNA damage (Bakthavatchalu et al, 2012).…”

Section: Mn +3 -Sod + O2 *-→ Mn +2 -Sod + O2mentioning

confidence: 99%

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

Guo¹,

Chen²

2012

Antioxidant Enzyme

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“…Finally, this study provides valuable information for potential intervention studies on therapeutic approaches (Li & Zhou, 2011) to reduce progressive disorders associated with T2D.…”

Section: This Study Also Investigated the Levels Of Dietary Intake Ofmentioning

confidence: 99%

“…Nitrogen oxide. MnSOD plays a key role in the protection of the mtDNA damage from oxidative stress (Li & Zhou, 2011). Lumini, Magalhaes, Oliveira, and Ascensao (2008) stated that the dysfunction of the mitochondria produces reduced uncoupling proteins (UCPs).…”

Section: Diabetes and 8-hydroxy-2'-deguanosine (8ohdg)mentioning

confidence: 99%

The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes

MCLEAN¹

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MCLEAN, MICHAEL ANDREW, "The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes" (2014 ), higher energy intake (2148 vs. 1770 kcal), and were more educated as compared to Haitian Americans; all variables were significant at p < .001. Serum levels of 8OHdG and MnSOD for African Americans (1691.0 ± 225.1 pg/ml, 2538.0 ± 1091.8 pg/ml; respectively) were significantly higher than for Haitian Americans (1626Americans ( .2 ± 222.9, 2015.3 pg/ml; respectively). 8OHdG was negatively correlated with MnSOD (r = -.167, p < .001) in T2D. Having T2D was negatively correlated with MnSOD (r = -.337; p < .01) and positively correlated with 8OHdG (r = .500; p < .01). African Americans and Haitian Americans with T2D had fasting plasma glucose (FPG) levels of 143.0 ± 61.0 mg/dl and viii 157.6 ± 65.5 mg/dl, and A1C of 7.5 ± 1.8 % and 8.4 ± 2.4 %, respectively. African Americans and Haitian Americans without T2D had FPG levels of 95.8 ± 13.2 mg/dl and 98.7 ± 16.9 mg/dl, and A1C of 5.9 ± 0.4% and 6.0 ± 0.5%, respectively. Dietary intakes of vitamin C and vitamin D were negatively correlated with FPG (r = -.21; r = -.19, p < .05) respectively. Carotenoids negatively correlated with A1C (r = -.19, p < .05). Lower levels of MnSOD were associated with lower levels of zinc, r = .10, p < .05, and higher levels of carotenoids r = -.10, p < .05. Higher levels of 8OHdG were associated with lower levels of Vitamin D, r = -.14, p < .01, and carotenoids, r = -.09, p < .05.The results demonstrate greater oxidative mtDNA damage in persons with T2D compared to those without T2D and in African Americans compared with Haitian Americans. The inverse relationship between dietary intake of antioxidants and oxidative stress implies a potential to reduce oxidative stress with diet.

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The Role of Manganese Superoxide Dismutase in Inflammation Defense

Cited by 100 publications

References 51 publications

Superoxide Dismutase Levels of Operator Gas Stations in Semarang, Central Java, Indonesia.

Superoxide Dismutase Levels of Operator Gas Stations in Semarang, Central Java, Indonesia.

Mitochondrial Free Radicals, Antioxidants, Nutrient Substances, and Chronic Hepatitis C

The relationship among serum levels of manganese superoxide dismutase and mtDNA 8-hydroxy-2'-deoxyguanosine, and dietary antioxidants intake in Type 2 Diabetes

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