The role of long non-coding RNA HOTAIR in the progression and development of laryngeal squamous cell carcinoma interacting with EZH2

Zheng, Jie; Xiao, Xiyan; Wu, Chunping; Huang, Jiayuan; Zhang, Yanping; Xie, Ming; Zhang, Ming; Zhou, Liang

doi:10.1080/00016489.2016.1214982

Cited by 31 publications

(29 citation statements)

References 20 publications

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“…In SCCHN, HOTAIR is able to regulate the activity of the well-known oncogene PTEN, by influencing promoter methylation [ 25 ]. In addition, it plays an important role in the epithelial-mesenchymal transition (EMT) repressing expression of E-cadherin through interaction with EZH2 [ 23 , 27 ]. Overexpression of HOTAIR can also inhibit apoptosis through modification of the mitochondrial membrane and activation of the mitochondrial calcium uptake dependent cell death [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

et al. 2017

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IntroductionLong noncoding RNAs (lncRNAs) are often dysregulated in cancer tissue and seem to play an important role in neoplastic processes. Recent studies have shown that the HOX transcript antisense intergenic RNA (HOTAIR) may play a role as a marker of prognosis in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to perform a meta-analysis of studies focused on the prognostic role of HOTAIR in SCCHN.ResultsAt the end of the selection process, four studies were considered eligible for inclusion in the meta-analysis, comprising a total of 271 patients. Meta-analysis revealed that high expression of HOTAIR was associated with poor overall survival (HR, 1.90; 95% CI: [1.42, 2.53]; p < 0,0001), advanced tumor stage (OR, 3.44; 95% CI: [1.84, 6.43]; p < 0,001) and lymph-node metastasis (OR, 3.31; 95% CI: [1.24, 8.79]; p = 0,02).Materials and MethodsThe literature search was performed in the following databases: PUBMED, SCOPUS, EMBASE and Web of Science, in order to find studies that met the inclusion criteria.ConclusionsFindings from this systematic review and meta-analysis revealed that HOTAIR represents a potential biomarker of prognosis in patients with squamous cell carcinoma of the head and neck.

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Section: Discussionmentioning

confidence: 99%

Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

et al. 2017

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“…Extensive research efforts on the carcinogenesis, development and effective therapeutic methods of HNCs, in which non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long ncRNAs (lncRNAs), were inevitably involved, have been conducted [6,7]. Researchers suggested that ncRNAs comprise most of the human transcriptome, while protein-coding genes accounted for only a tiny sliver, less than 2%, of the total genome [8,9].…”

Section: Introductionmentioning

confidence: 99%

Circular RNAs and their roles in head and neck cancers

et al. 2019

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Circular RNAs are abundant endogenous non-coding RNA with no 5′ cap and 3′ polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Recent studies have indicated that circular RNAs are involved in the tumorigenesis, progression, invasion and chemosensitivity of head and neck cancers and that some circular RNAs could serve as diagnostic and prognostic biomarkers. In this study, we summarize research advances in the regulation of circular RNA biogenesis, their characteristics and functions, the involvement of circular RNAs in the pathophysiology of head and neck cancers and their potential clinical utilization, as well as the likely directions of future studies.

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“…Thus, HOTAIR could serve as a biomarker and potential target for therapeutic intervention in LSCC [125]. HOTAIR and the core component of PRC2 EZH2 were overexpressed in LSCC tissues, and reduction of HOTAIR expression stimulated EZH2 expression, promoting proliferation and increasing sensitivity to cis-platinum in LSCC cells [126].…”

Section: Hotair In Head and Neck Cancermentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

215

135

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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The role of long non-coding RNA HOTAIR in the progression and development of laryngeal squamous cell carcinoma interacting with EZH2

Cited by 31 publications

References 20 publications

Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

Circular RNAs and their roles in head and neck cancers

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

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