The role of long intergenic noncoding RNA 00511 in malignant tumors: a meta-analysis, database validation and review

Ding, Jianlong; Cao, Junyan; Chen, Zhaocong; He, Zhiming

doi:10.1080/21655979.2020.1795384

Cited by 17 publications

(16 citation statements)

References 31 publications

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“…Advanced tumors are often malignant, prone to relapse after treatment and have poor prognosis. Many diagnostic and prognostic markers have been applied to cancers, but the results may be not satisfactory [ 33–35 ]. Thus, it is important to identify more effective prognostic markers.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of microRNA miR-24 in cancers: a meta-analysis

et al. 2021

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The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated the prognostic value of miR-24 in tumors were included. The hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CI) were used to evaluate survival outcomes and clinical characteristics. All data analyses were implemented using STATA 12.0 software. A total of 17 studies from 15 articles involving 1705 patients were collected for the meta-analysis. The pooled analysis revealed that elevated miR-24 expression was obviously associated with poor overall survival (OS) (HR = 1.66, 95% CI: 1.20-2.31). Furthermore, we also found that elevated miR-24 expression was positively correlated with tumor size (large or small) and tumor stage (III-IV vs I-II). Elevated miR-24 expression indicates poor prognosis and may be a promising prognostic marker in different cancers. Our findings needed to be verified through further investigations.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of microRNA miR-24 in cancers: a meta-analysis

et al. 2021

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“…The Q statistic and I 2 was used to test and quantify heterogeneity. The random effect model is chosen to calculate the pooled SMD with 95% CI, when the p value of the Cochrane Q test was <0.05 or I 2 is ≥50% [ 30 , 31 ]. Otherwise, the random effect model was used.…”

Section: Methodsmentioning

confidence: 99%

“…Otherwise, the random effect model was used. Sensitivity analyses were performed by omitting a single study in each step [ 30 , 31 ]. Subgroup analyses were conducted by age, country, and the definition of severe GI involvements.…”

Section: Methodsmentioning

confidence: 99%

Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch–Schonlein Purpura: a meta-analysis

Ren

Ling

et al. 2021

Bioengineered

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The association of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with the severe gastrointestinal (GI) involvement in pediatric Henoch-Schonlein Purpura (HSP) has been reported in many studies. However, the conclusions from the previous studies were controversial. Therefore, for the first time, we performed a meta-analysis to systematically evaluate the relationship of NLR and MPV to the severe GI involvements. We retrieved PubMed, EMBASE, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) (up to October 2020) thoroughly to acquire eligible studies. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to describe the correlation of NLR and MPV with the severe GI involvement. A total of 1 2 studies comprising 2168 patients with HSP were included in this meta-analysis. Our combined analysis showed that NLR in HSP patients with the severe GI involvement was significantly higher than that in those without the severe GI involvement (SMD = 1.37; 95% CI: 0.70-2.05; p < 0.01). In addition, a lower MPV was observed in children with severe GI involvement (SMD = −0.29; 95% CI: −0.56 -−0.01, p = 0.042). Our sensitivity analysis and publication bias evaluation indicated that our combined results were reliable. Taken together, our study suggested NLR and MPV may be used as biomarkers for predicting or diagnosing the severe GI involvement in children with HSP. Nevertheless, more homogeneous studies with a larger sample size are required to validate these findings.

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“…Therefore, lncRNAs are a major class of RNA molecules which exert a powerful effect on various physiological and pathological processes involving in tumor growth, progression, and prognosis. In addition, lncRNAs could provide potential clues for developing novel therapeutic approaches for cancers [8]. Previous studies have found that lncRNA HOX antisense intergenic (HOTAIR) is significantly increased in cancerous tissues in comparison to normal tissues in gastric cancer, urothelial cell carcinoma and renal cell carcinoma [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, lncRNAs could provide potential clues for developing novel therapeutic approaches for cancers [8]. Previous studies have found that lncRNA HOX antisense intergenic (HOTAIR) is significantly increased in cancerous tissues in comparison to normal tissues in gastric cancer, urothelial cell carcinoma and renal cell carcinoma [8][9][10]. Additionally, lncRNA HOTAIR is closely related to cell proliferation and migration ability [10].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic

Wang

et al. 2021

Bioengineered

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Ginsenoside Rg3, a natural compound, has been reported to function as an anticancer agent for hepatoma carcinoma, while the mechanisms underlying the anticancer effects are not clear. Therefore, the objective of our study was to explore the impact of RG3 on cell migration and invasion by regulating the lncRNA HOX antisense intergenic (HOTAIR) expression involving PI3K/ AKT signaling pathway. qRT-PCR was utilized to measure the mRNA expression of HOTAIR. Furthermore, HOTAIR overexpression plasmids were transfected to SMMC-7721 and SK-Hep-1 cells. Additionally, MTT assay was used to evaluate the proliferation of transfected cells. The scratch and transwell assays were used to determine the migration and invasion ability of the cell. The protein levels were determined with Western blot. lncRNA HOTAIR was overexpressed in SMMC-7721 and SK-Hep-1 cells. Ginsenoside-Rg3 reduced the level of lncRNA HOTAIR. Overexpressed lncRNA HOTAIR offset ginsenoside-Rg3 inhibited proliferation, migration and invasion of HCC cells. Furthermore, ginsenoside-Rg3 decreased the expression of p-AKT, p-PI3K, matrix metalloproteinase-2 (MMP2) and matrix metalloproteinase-9 (MMP9), which was reversed after the treatment of HOTAIR. LncRNA HOTAIR was overexpressed in SMMC-7721 cells. Ginsenoside-Rg3 could reduce the expression of lncRNA HOTAIR, resulting in the inhibited cell proliferation, migration and invasion. Furthermore, ginsenoside-Rg3 inhibited cell proliferation and invasion ability through the PI3k/AKT pathway. Thus, ginsenoside-Rg3 might be a potential and effective treatment for HCC.

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The role of long intergenic noncoding RNA 00511 in malignant tumors: a meta-analysis, database validation and review

Cited by 17 publications

References 31 publications

Prognostic significance of microRNA miR-24 in cancers: a meta-analysis

Prognostic significance of microRNA miR-24 in cancers: a meta-analysis

Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch–Schonlein Purpura: a meta-analysis

Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic

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