The role of lipid peroxidation products and antioxidant enzymes in the pathogenesis of aseptic and purulent inflammation in cats

Руденко, П. А.; Vatnikov, Y.A.; Engashev, S.V.; Квочко, А. Н.; Notina, Elena; Bykova, Irina; Kulikov, E.V.; Rudenko, A A; Petrukhina, O. A.; Rudenko, V. B.

doi:10.5455/javar.2021.h504

Cited by 17 publications

(11 citation statements)

References 23 publications

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“…ANIMAL THERAPY Введение В последнее время регистрируется значительное увеличение количества кошек, которые становятся полноценными членами наших семей. Кошкам присущ ряд неоспоримых достоинств: они улучшают наше настроение, уменьшают эмоциональное и физическое напряжение, помогают своим владельцам справиться с депрессией, создают ощущение экзальтации, а также теплую и уютную обстановку в домашнем очаге [1][2][3].…”

Section: терапия животныхunclassified

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

2022

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Relevance. Despite the constant improvement of methods for correcting the intestinal microbiota, the occurrence of dysbacteriosis in various pathological processes not only does not decrease, but, on the contrary, increases. Therefore, the choice of the optimal therapeutic regimen for the correction of the lightest compensated degree of intestinal dysbiosis in cats, in our opinion, is an urgent direction of scientific research in veterinary medicine.Methods. Evaluation of the effectiveness of pharmacotherapy in cats with compensated intestinal dysbiosis (n = 15) is given. The animals were divided by the envelope method into two experimental groups: A1 (n = 6) and A2 (n = 9). The dynamics of individual hematological and immunological blood parameters of cats with grade 1 dysbiosis in the course of their therapy (before treatment, on days 7 and 14) is shown.Results. With compensated intestinal dysbiosis in cats, the appointment of the Purina Pro Plan dietary food shows a therapeutic effect, which leads to an overall clinical improvement as early as after 6.16±0.60 days. However, the use of the probiotic «Lactobifadol» against the background of diet therapy normalizes appetite after 2.39 days, an unpleasant odor from the oral cavity after 0.84 days, feces after 0.89 days, accelerates the overall clinical improvement of animals with intestinal dysbiosis of the 1st degree by 2.16 days earlier, when compared with the indicators of cats of the A1 group.

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Section: терапия животныхunclassified

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

2022

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“…As a result, not only conditionally pathogenic microflora are activated but even saprophytic microorganisms. This situation creates ample opportunities for various combinations of bacterial formation in the biotopes of the animal organism, leading to poor quality microbiocenoses [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

et al. 2022

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Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose of the study was a detailed analysis of the quantitative and qualitative fecal microbiota spectrum in cats with intestinal dysbiosis of varying severity. The data obtained indicate that, depending on the dysbiosis severity in cats, the intestinal microbiome landscape changes significantly. It has been established that, depending on the dysbiosis severity, there is a shift in the balance between the Gram-positive and Gram-negative bacterial pools and in the nature of the isolation of specific bacteria forms, in the amount of obligate microbiota isolation, as well as individual facultative strains. When analyzing the serotyping of E. coli cultures isolated at various grades of intestinal dysbiosis severity, differences were found both in the isolation amount of various serotypes from one animal and in the prevalence of certain serotypes for each disease severity. A retrospective analysis of the fecal microbiota sensitivity in cats with dysbiosis to antibacterial drugs showed that, depending on the disease severity, the number of isolates sensitive to antibiotics increases significantly.

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“…Данная патология остается повседневной практикой ветеринарных учреждений и характеризуется разнообразием своего проявления, а также большим интересом со стороны научного сообщества [4,5]. Постановка диагноза при дисбиозе кишечника представляет значительную трудность, поскольку данный синдром, не имея четкой клинической манифестации, зачастую признается врачом незначительным, при этом упускается из виду уже развивающийся патологический процесс [6][7][8][9][10]. В этой связи, несмотря на разнообразие причин как эндогенного, так и экзогенного характера, лежащих в основе количественного и качественного нарушения равновесия микробиома кишечника, его развитие всегда сопровождается увеличением условно патогенных микроорганизмов с усилением вирулентности и приобретением патогенных свойств на фоне уменьшения представителей индигенной микробиоты [5,[11][12][13][14].…”

Section: Introductionunclassified

“…Отдельные авторы [18][19][20] высказывают предположение о негерметичности кишечника при дисбактериозе как инициирующем факторе микробной транслокации, которая приводит к патологическим последствиям различного генеза. Рядом исследователей установлено снижение разнообразия и богатства фекального микробиома при инфекционных и незаразных патологиях у кошек [3,7,11,[21][22][23]. Получены данные о механизмах формирования и прогрессирования дисбактериоза кишечника у кошек при различных формах хирургической инфекции [24,25].…”

Section: Introductionunclassified

Features of the clinical manifestation of subcompensated intestinal dysbiosis in cats in assessing the effectiveness of its correction

Руденко

Sotnikova²,

Krotova³

et al. 2022

Vestn. Ross. univ. družby nar., Ser. Agron. životnovod.

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Formation and reproduction of gut microbiome begins at birth, while change in its composition depends mainly on various genetic, nutritional and environmental factors. The article considers the features of clinical manifestation of subcompensated intestinal dysbiosis in cats in assessing the effectiveness of its treatment. The studies were carried out on the basis of Department of Veterinary Medicine, RUDN University, and the clinical work was conducted at private veterinary clinics: Avettura, Epiona, In the World with Animals. Cats were selected for the experiment as they arrived at the initial appointment at veterinary clinics. The diagnosis of suspected intestinal dysbacteriosis was made considering anamnesis, clinical examination, and microbiological tests. The severity of intestinal dysbacteriosis was assessed on the results of clinical and laboratory studies. During the research, clinical and diagnostic approaches for subcompensated intestinal dysbacteriosis in cats were improved. Furthermore, effective ways of its treatment were developed. For subcompensated intestinal dysbacteriosis, administration of Lactobifadol probiotic, Vetelakt prebiotic and Azoksivet immunomodulator showed the greatest therapeutic effect, which led to an overall clinical improvement in 5.50 days. Therapeutic efficacy of B3 regimen was also clearly evidenced by the positive changes in intestinal microbiota and hematological blood parameters during the pharmacorrection. Improvement of clinical diagnostic approaches, prognosis of intestinal dysbiosis of varying severity and treatment effectiveness in cats require will allow to study intestinal dysbiotic disorders in other animal species.

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The role of lipid peroxidation products and antioxidant enzymes in the pathogenesis of aseptic and purulent inflammation in cats

Cited by 17 publications

References 23 publications

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

Evaluation of the effectiveness of therapy for compensated intestinal dysbiosis in cats

Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

Features of the clinical manifestation of subcompensated intestinal dysbiosis in cats in assessing the effectiveness of its correction

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