The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

Никитин, П.В.; Потапов, А А; Ryzhova, Marina; Shurkhay, Vsevolod; Kulikov, Eugene E.; Zhvanskiy, E S; Popov, Igor; Nikolaev, Eugene

doi:10.17116/neiro2018823112

Cited by 3 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies revealed that lipid metabolism disorders are important in carcinogenesis and cancer development, as they induce abnormalities in the expression of various genes and proteins, and in the regulation of cytokines and signaling pathways (17,18). The present study demonstrated that lipid metabolism disorders occurred in patients with TC.…”

Section: Discussionsupporting

confidence: 59%

Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile

Zhou

et al. 2019

Oncol Lett

View full text Add to dashboard Cite

The serum lipid profile and clinical outcomes of cancer patients are commonly correlated in a wide range of carcinomas. However, few studies have investigated the serum lipid profile of patients with thyroid cancer (TC). The present study therefore aimed to analyze the lipid profiles of patients with TC. The serum proteomes of 31 participants with stage I-IV TC were screened using Orbitrap Q Exactive Plus. Analytical data collected between November 1, 2013 and November 11, 2018 from the laboratory information system included the total cholesterol (CHO), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), lipoprotein (a) and apolipoprotein B (ApoB) levels that were used to validate the screening results. A total of 3875 outpatients were enrolled in this study. A number of 17 differentially expressed proteins were identified. An Ingenuity pathway analysis identified activation of the liver X receptor/retinoid X receptor (LXR/RXR) activation, which is a crucial pathway involved in lipid metabolism. The results demonstrated that the total CHO levels were significantly different between patients with TC and control groups, both in men and women. In women, the levels of TG, HDL-C, Apo A1 and LDL-C/HDL-C were significantly different between patients with TC and control groups (all P<0.05). Higher concentrations of TG and LDL-C/HDL-C were observed in the cancer group compared with the control group. However, lower levels of Apo A1 and HDL-C were observed in women from the cancer group compared with the control group. The results from the present study revealed the presence of a disordered lipid profile in patients with TC. The molecular mechanism underlying the association between lipid metabolism and cancer requires further investigation and may be used to develop novel diagnostic biomarkers and therapeutic targets in human cancers.

show abstract

Section: Discussionsupporting

confidence: 59%

Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile

Zhou

et al. 2019

Oncol Lett

View full text Add to dashboard Cite

show abstract

“…Many studies focus on the relationship between abnormal blood lipid metabolism and cancer. Recent studies have revealed that lipid metabolism disorders occur in carcinogenesis and the development of cancer, as cancer induces abnormalities in the expression of various genes and proteins, as well as in the regulation of cytokines and signaling pathways [21,22]. A study by Li et al found that the TC levels were signi cantly different between patients with thyroid cancer and control groups, and a disordered lipid pro le occurred in patients with thyroid cancer [2].…”

Section: Discussionmentioning

confidence: 99%

Lipid metabolism disturbances in papillary thyroid cancer patients and the relationship with iodine nutrition status

Zhai

Wang

Luo

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: Cancer patients are frequently accompanied by problems in lipid metabolism. Uncertainty exists as to whether changes in serum lipids occur in patients with papillary thyroid cancer (PTC) and their relationship with iodine nutrition remains obscure. The aim of this study was to explore lipid metabolism disturbances in PTC patients and their relationship with iodine nutrition status. Methods: A total of 909 patients who were initially diagnosed with PTC and 183 patients who were initially diagnosed with benign thyroid nodules were enrolled in this study. The serum iodine concentration (SIC), the urine iodine concentration (UIC) and nine serum lipids indicators were measured. The generalized linear model (GLM) together with other statistical methods were used to determine whether there were differences in serum lipids between patients with PTC and those with benign thyroid nodules. Results: After adjusting for baseline information, triglycerides (TG) levels in the control group (4.29±1.21) were significantly higher than in the cancer group (1.59±1.25). The rate of abnormal thyroid function was significantly lower in the patients with PTC than in the patients with benign nodules. In the PTC patients, different clinicopathological features had an impact on thyroid function, as reflected by a significant increase in FT3 in PTC with lymph node metastases, a significant increase in TSH, TGAb, and TPOAb, and a significant decrease in FT4 in PTC with AITD. Correlation analysis revealed weak to moderate correlations between iodine nutritional status, thyroid function, and serum lipids. In benign thyroid nodule patients, LDL-C and ApoB values in patients with benign thyroid nodules were significantly higher in the high SIC group than in the adequate and deficient groups. In PTC patients. ApoE levels in the low UIC group were significantly higher than in the middle and high UIC groups. Mediating effects were used to analyze the effect of iodine nutrition on the serum lipids, it showed that the total and direct effects of iodine nutritional status on serum lipids were significant, and the mediating effect of thyroid function was not significant. Conclusion: TG levels in the control group were significantly higher than in the PTC group. Iodine nutritional status influences lipids, and an excess or deficient iodine nutrition increases the risk of dyslipidemia in patients with thyroid nodule. Iodine nutritional status had a direct effect on serum lipids.

show abstract

Molecular characteristics of anaplastic astrocytomas and isolation of molecular subgroups of their IDH1 mutant forms using in silico analysis

2020

Self Cite

View full text Add to dashboard Cite

Актуальность. Проблема анапластических астроцитом достаточно актуальна в наши дни. В классификации Всемирной организации здравоохранения выделяются анапластическая астроцитома с мутацией в генах IDH1 и IDH2, анапластическая астроцитома без мутаций в генах IDH1 и IDH2, анапластическая астроцитома без дополнительного генетического уточнения. Целью данной работы стало кластерирование анапластических астроцитом с мутацией в гене IDH1 на основе их цитогенетического профиля для выделения прогностически значимых молекулярных подгрупп, которые могут иметь как клинико-практическое, так и фундаментально-научное значение. Проведен кластерный анализ анапластических астроцитом по их цитогенетическим профилям на основе доступных генетических баз данных опухолей и крупных когортных исследований, а также сравнение кривых выживаемости Каплана-Мейера для различных молекулярных подгрупп пациентов. Результаты. Нам удалось изучить основные генетические особенности межопухолевой гетерогенности анапластических астроцитом и выделить на основе цитогенетического профиля семь молекулярных подгрупп-эмбриональноподобную, инфламмоподобную, делеционную, матриксную, циклиновую, GATA3зависимую и тирозинкиназную. При этом каждая из этих подгрупп имеет не только отличительные молекулярные характеристики, но и важные клинические особенности. Заключение. Детальное изучение молекулярных свойств анапластических астроцитом позволит не только оптимизировать процесс прогнозирования исходов лечения, но и создать инновационные форматы для таргетной терапии в рамках концепции персонализированной медицины. Ключевые слова: анапластическая астроцитома, мутация гена IDH1, межопухолевая гетерогенность. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Источник финансирования. Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта № 18-29-01034. Для цитирования: Никитин П.В., Беляев А.Ю., Рыжова М.В. Молекулярно-биологические особенности анапластических астроцитом и выделение молекулярных подгрупп их IDH1-мутантных форм с помощью анализа in silico.

show abstract

The role of lipid metabolism disorders, atypical isoforms of protein kinase C, and mutational status of cytosolic and mitochondrial forms of isocitrate dehydrogenase in carcinogenesis of glial tumors

Cited by 3 publications

References 79 publications

Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile

Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile

Lipid metabolism disturbances in papillary thyroid cancer patients and the relationship with iodine nutrition status

Molecular characteristics of anaplastic astrocytomas and isolation of molecular subgroups of their IDH1 mutant forms using in silico analysis

Contact Info

Product

Resources

About