The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism

Mayneris‐Perxachs, Jordi; Moreno-Navarrete, José María; Fernández-Real, José Manuel

doi:10.1038/s41574-022-00721-3

Cited by 60 publications

(45 citation statements)

References 169 publications

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“…Iron might have a role in the modulating effects of bacterial-derived SCFAs [ 173 ]. The use of an iron-deficient diet in rats reduced butyrate- and propionate-producing bacteria compared to the control animals [ 174 ], which might be due to the need for iron by the enzymes that are involved in SCFAs synthesis.…”

Section: Polyphenol-mediated Iron Sequestration Affects the Inflammat...mentioning

confidence: 99%

The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

et al. 2023

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In the past decades, many studies have widely examined the effects of dietary polyphenols on human health. Polyphenols are well known for their antioxidant properties and for their chelating abilities, by which they can be potentially employed in cases of pathological conditions, such as iron overload. In this review, we have highlighted the chelating abilities of polyphenols, which are due to their structural specific sites, and the differences for each class of polyphenols. We have also explored how the dietary polyphenols and their iron-binding abilities can be important in inflammatory/immunomodulatory responses, with a special focus on the involvement of macrophages and dendritic cells, and how they might contribute to reshape the gut microbiota into a healthy profile. This review also provides evidence that the axes “polyphenol–iron metabolism–inflammatory responses” and “polyphenol–iron availability–gut microbiota” have not been very well explored so far, and the need for further investigation to exploit such a potential to prevent or counteract pathological conditions.

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Section: Polyphenol-mediated Iron Sequestration Affects the Inflammat...mentioning

confidence: 99%

The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

et al. 2023

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“…Additional pathological changes may be also intimately associated with IR. For example, compositional and functional alterations in gut microbiota have been observed in patients with IR and metabolic dysfunction, 25 which may modulate cellular metabolism and energy homeostasis through homeostatic and pathogenic microbiota‐host interactions. In addition, a decrease in circulating adiponectin, an insulin‐sensitizing, anti‐inflammatory, antiatherosclerotic, and hepato‐protective factor predominantly produced by adipocytes, 26 has been shown to extensively promote hepatic and muscular IR 27–30 …”

Section: Pathological Features Of T2dmmentioning

confidence: 99%

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao

Tian

Zhang

et al. 2023

MedComm

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Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for a broad range of comorbidities, including vascular, visual, neurological, kidney, and liver diseases. Moreover, recent data suggest a mutual interplay between T2DM and Corona Virus Disease 2019 (COVID‐19). T2DM is characterized by insulin resistance (IR) and pancreatic β cell dysfunction. Pioneering discoveries throughout the past few decades have established notable links between signaling pathways and T2DM pathogenesis and therapy. Importantly, a number of signaling pathways substantially control the advancement of core pathological changes in T2DM, including IR and β cell dysfunction, as well as additional pathogenic disturbances. Accordingly, an improved understanding of these signaling pathways sheds light on tractable targets and strategies for developing and repurposing critical therapies to treat T2DM and its complications. In this review, we provide a brief overview of the history of T2DM and signaling pathways, and offer a systematic update on the role and mechanism of key signaling pathways underlying the onset, development, and progression of T2DM. In this content, we also summarize current therapeutic drugs/agents associated with signaling pathways for the treatment of T2DM and its complications, and discuss some implications and directions to the future of this field.

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“…It appears that the intestinal iron availability affects the gut microbiome, which in turns plays a central role in the absorption of iron in the intestine and bacteria-derived metabolites. This two-way interaction between iron homeostasis and the gut microbiota affects systemic glucose metabolism (126). The observation that important iron-processing orthologs are significantly overexpressed in the Sugar Shift-treated group seems to suggest that this formulation alleviates insulin resistance by promoting iron homeostasis via promotion of a "healthier" microbiome.…”

Section: Functional Biomarkersmentioning

confidence: 99%

A Randomized Placebo Controlled Clinical Trial of a Metabolic Shifting Probiotic, Sugar Shift, for the Treatment of T2DM

Garcı́a

Soto

Rodríguez

et al. 2022

Preprint

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance and chronic inflammation. Probiotics have been claimed effective in the management of obesity and type 2 diabetes mellitus. BiotiQuest™ Sugar Shift is a symbiotic formulation rationally designed for the endogenous conversion of glucose and fructose to support restoration of the human gut microbiota, modulation of intestinal glucose, and the production of anti-inflammatory metabolites. We report the results of a 12-week, double blind, placebo-controlled study designed to evaluate Sugar Shift in Cuban T2DM patients. Clinical parameters, including fasting and 2h post-prandial glucose, hemoglobin A1c, a lipid panel, insulin, creatinine, and serum lipopolysaccharide levels were assessed. Microbiome composition was assessed by 16S amplicon sequencing of the variable region V3-V4 of the 16S rRNA gene. Metabolic biomarkers were inferred from microbiome data by Kruskal-Wallis H test and LEfSe. Fasting glucose, Insulin, and serum LPS levels decreased significantly at day 84 as compared to day 1 in the treated group and to control group. Hb A1c remained stable in the treatment group as compared to the controls but not show significant improvement in the study period. Microbiome analysis showed significant increase in Chao1 alpha diversity in the treated group between day 1 and day 84. Taxonomic and functional biomarkers revealed significant differences between the Day 1 and Day 84 microbiome profiles in the treatment group, primarily associated with acetate, propionate, and butyrate production. Our results indicate that Sugar Shift can be a suitable adjunct therapy to standard of care therapy in the management of T2DM based upon the improvement in key inflammatory and insulin resistance markers. These results were interpreted as an indication of favorable microbiome changes during the course of the treatment for 12 weeks

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The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism

Cited by 60 publications

References 169 publications

The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

The Chelating Ability of Plant Polyphenols Can Affect Iron Homeostasis and Gut Microbiota

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

A Randomized Placebo Controlled Clinical Trial of a Metabolic Shifting Probiotic, Sugar Shift, for the Treatment of T2DM

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