Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, Rong; Tian, Huimin; Zhang, Yanbo; Li, Geng; Xu, Haixia; Rao, Guocheng; Tian, Yan; Fu, Xianghui

doi:10.1002/mco2.283

Cited by 7 publications

(4 citation statements)

References 676 publications

(1,304 reference statements)

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“…Under typical circumstances, serum leptin levels are low while adiponectin is raised. These adipocytokines are noteworthy markers that are essential for sustaining the harmony between lipid and carbohydrate metabolism, which, over time, regulates inflammation and insulin signaling [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

El Azab,

Alakilli,

Saleh

et al. 2023

IJMS

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Type 2 diabetes (T2D) is a chronic metabolic condition associated with obesity, oxidative stress-mediated inflammation, apoptosis, and impaired insulin signaling. The utilization of phytochemical therapy generated from plants has emerged as a promising approach for the treatment of diabetes and its complications. Kiwifruit is recognized for its substantial content of antioxidative phenolics. Therefore, this work aimed to examine the effect of Actinidia deliciosa (kiwi fruit) on hepatorenal damage in a high-fat diet (HFD) and streptozotocin (STZ)-induced T2D in rats using in vivo and in silico analyses. An increase in hepatic and renal lipid peroxidation was observed in diabetic rats accompanied by a decrease in antioxidant status. Furthermore, it is important to highlight that there were observable inflammatory and apoptotic responses in the hepatic and renal organs of rats with diabetes, along with a dysregulation of the phosphorylation levels of mammalian target of rapamycin (mTOR), protein kinase B (Akt), and phosphoinositide 3-kinase (PI3K) signaling proteins. However, the administration of kiwi extract to diabetic rats alleviated hepatorenal dysfunction, inflammatory processes, oxidative injury, and apoptotic events with activation of the insulin signaling pathway. Furthermore, molecular docking and dynamic simulation studies revealed quercetin, chlorogenic acid, and melezitose as components of kiwi extract that docked well with potential as effective natural products for activating the silent information regulator 1(SIRT-1) pathway. Furthermore, phenolic acids in kiwi extract, especially syringic acid, P-coumaric acid, caffeic acid, and ferulic acid, have the ability to inhibit the phosphatase and tensin homolog (PTEN) active site. In conclusion, it can be argued that kiwi extract may present a potentially beneficial adjunctive therapy approach for the treatment of diabetic hepatorenal complications.

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Section: Discussionmentioning

confidence: 99%

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

El Azab,

Alakilli,

Saleh

et al. 2023

IJMS

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“…It is widely recognized that individuals with a genetic predisposition are most susceptible to developing type 2 diabetes as a result of overnutrition, sedentary lifestyle, and consequent obesity. In fact, to effectively manage this disease, regular physical exercise and a suitable dietary regimen are considered fundamental measures [95].…”

Section: Type 2 Diabetesmentioning

confidence: 99%

From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies

Rey

Tamargo‐Gómez

2023

Kinases and Phosphatases

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Adenosine Monophosphate-Activated Protein Kinase (AMPK) is the major conserved regulator of cellular metabolism in eukaryotic cells, from yeast to mammals. Given its pivotal role, it is not surprising that alterations in its function may contribute to the pathogenesis of numerous human diseases. Indeed, AMPK has become a promising therapeutic target for several pathologies. In this context, significant efforts have been dedicated to discovering new pharmacological agents capable of activating AMPK based on next-generation sequencing (NGS) technology and personalized medicine. Thanks to computational methodologies and high-throughput screening, the identification of small molecules and compounds with the potential to directly activate AMPK or modulate its intricate signaling network has become viable. However, the most widely used drug to activate AMPK in human patients is still metformin, which has shown promising results in the treatment of various diseases, such as type II diabetes, atherosclerosis, Alzheimer’s disease, Huntington’s disease, and several types of cancer. In this review, we present a comprehensive analysis of the involvement of AMPK in human pathology, emphasizing its significant potential as a therapeutic target.

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“…[ 180 , 388 ] Interestingly, SWELL, an ion channel controlling insulin sensitivity, is of mechanosensitivity, suggesting a link of mechanotransduction to insulin resistance, [ 172 ] the key pathological change in various metabolic disorders which is also regulated by numerous molecules. [ 389 , 390 , 391 , 392 ] In addition, hyperglycemia can alter the mechanical properties of plasm membrane of dorsal root ganglion neurons by eliciting osmotic disorder, methylglyoxal and ROS overproduction, therefore bringing about the malfunction of mechanosensitive channels and thus diabetic neuropathy progression. [ 393 ]…”

Section: Mechanotransduction In Diseasesmentioning

confidence: 99%

A Hierarchical Mechanotransduction System: From Macro to Micro

Cao,

Tian,

Tian

et al. 2023

Advanced Science

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Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities. However, the actions and mechanisms of mechanotransduction across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to the whole‐body level, have not been yet comprehensively documented. Herein, the biological roles and operational mechanisms of mechanotransduction from macro to micro are revisited, with a focus on the orchestrations across diverse hierarchies. The implications, applications, and challenges of mechanotransduction in human diseases are also summarized and discussed. Together, this knowledge from a hierarchical perspective has the potential to refresh insights into mechanotransduction regulation and disease pathogenesis and therapy, and ultimately revolutionize the prevention, diagnosis, and treatment of human diseases.

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Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cited by 7 publications

References 676 publications

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

Actinidia deliciosa Extract as a Promising Supplemental Agent for Hepatic and Renal Complication-Associated Type 2 Diabetes (In Vivo and In Silico-Based Studies)

From Kinases to Diseases: Investigating the Role of AMPK in Human Pathologies

A Hierarchical Mechanotransduction System: From Macro to Micro

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