The Role of IRF (Immature Reticulocyte Fraction) in Pancytopenia

Ray, Suchandra; Das, Chhanda; Roy, Sudip

doi:10.9734/bpi/rdmmr/v11/1994c

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“…However, IRF was valuable in making diagnoses of megaloblastic anemia, aplastic anemia, early marrow recovery from suppression, and hemolytic disease. 33 Thus, IRF is a strong indicator of post-chemotherapy aplasia in children with cancer. An increase in IRF within a few days indicates recovery of bone marrow following bone marrow transplantation, erythropoiesis-stimulating agent therapy, or chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9–11 Months

Ringoringo¹

2022

IJGM

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Background Iron deficiency anemia (IDA) is still a major global health problem. Determination of reference ranges for complete blood count (CBC), reticulocyte hemoglobin content (Ret-He), immature reticulocyte fraction (IRF), and reticulocyte production index (RPI) are essential to help diagnose a disease. Purpose The study aims to know the prevalence of IDA, risk factors that influence it, and set a reference range for CBC and reticulocyte parameters in infants aged 9–11 months in Indonesia. Patients and Methods The study was conducted prospectively at 10 Community Health Centers in Banjarbaru, South Kalimantan, Indonesia, from August 2020 to August 2021. Results This study recruited 100 healthy infants (47% boys, 53% girls) aged 9–11 months. The prevalence of IDA was 32%. There is no association between IDA prevalence with the mother’s education and occupation, maternal parity, family income, and infant nutritional status (p > 0.05). The reference range for hemoglobin (Hb) at P2.5-P97.5, P3-P97, P5-P95 and mean ± 2SD was 11.06 to 14.34 g/dL, 11.10 to 14.31 g/dL, 11.13 to 13.90 g/dL and 10.57 to 13.65 g/dL, respectively. This study also defined the reference ranges for reticulocyte parameters. Conclusion The reference range of CBC, Ret-He, IRF, and RPI for healthy infants aged 9–11 months in this study can be used as a benchmark.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9–11 Months

Ringoringo¹

2022

IJGM

View full text Add to dashboard Cite

show abstract

The Role of IRF (Immature Reticulocyte Fraction) in Pancytopenia

Cited by 1 publication

References 0 publications

Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9–11 Months

Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9–11 Months

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