2016
DOI: 10.17691/stm2016.8.4.29
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The Role of Ion Channels Expressed in Cerebral Endothelial Cells in the Functional Integrity of the Blood-Brain Barrier (Review)

Abstract: All anatomical elements contributing to the blood-brain barrier (BBB) play a crucial role in maintaining the permeability and CNS homeostasis under physiological/pathological conditions. These elements are endothelial cells, pericytes, astroglia, and neurons that are known as a neurovascular unit (NVU). Being the integral system, NVU contributes to the regulation of neuroplasticity, neurogenesis, intercellular communications and permeability of BBB. Brain capillary endothelial cells (BCEC) are the very importa… Show more

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Cited by 7 publications
(8 citation statements)
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“…When Cd is present in the blood stream, it can enter the cells by channels, transporters and receptors [124] that are present on the luminal surface of the BBB endothelial cells [125]. Once inside, Cd induces an oxidative stress response that in turn elicits an increase in the antioxidant enzymes' activity [104].…”
Section: Cadmium and Blood-brain Barriermentioning
confidence: 99%
“…When Cd is present in the blood stream, it can enter the cells by channels, transporters and receptors [124] that are present on the luminal surface of the BBB endothelial cells [125]. Once inside, Cd induces an oxidative stress response that in turn elicits an increase in the antioxidant enzymes' activity [104].…”
Section: Cadmium and Blood-brain Barriermentioning
confidence: 99%
“…Direct influence of an increased BBB permeability on the EED dynamics is generation signals of the BBB via electrophysiological properties of brain endothelial cells forming the BBB. The signals generated by the BBB originate from a trans-endothelial voltage between blood and brain tissue This voltage is a consequence of unequal endothelial cell apical and basolateral membrane potentials [ 77 ]. The ion influx/efflux changes the BBB permeability via brain endothelial cells membrane depolarization affecting the cell stiffness via molecular mechanisms underlying cortical actin cytoskeleton [ 77 , 78 ].…”
Section: Slow Wave Activity As a Biomarker Of Disruption Of Blood-mentioning
confidence: 99%
“…The signals generated by the BBB originate from a trans-endothelial voltage between blood and brain tissue This voltage is a consequence of unequal endothelial cell apical and basolateral membrane potentials [ 77 ]. The ion influx/efflux changes the BBB permeability via brain endothelial cells membrane depolarization affecting the cell stiffness via molecular mechanisms underlying cortical actin cytoskeleton [ 77 , 78 ]. These changes of cell potential cause up to mV-level shifts in human scalp EEG [ 78 , 79 ].…”
Section: Slow Wave Activity As a Biomarker Of Disruption Of Blood-mentioning
confidence: 99%
“…However, blood–brain barrier (BBB) dysfunction is associated with neurodegenerative disorders [ 116 ]. A study has reported that cadmium can enter the cells by destroying the BBB, when cadmium is present in the bloodstream [ 117 ], which causes neurotoxicity. In this review, we will focus on the role of autophagy in cadmium-induced neurotoxicity.…”
Section: The Toxicity Of Cadmium Toward the Kidney Liver Bone And Brainmentioning
confidence: 99%