The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

Yiğitbaşı, Mehmet Rafet; Guntaş, Gülcan; Atak, Tuba; Sönmez, Çiğdem; Yalman, Haydar; Uzun, Hafize

doi:10.1080/08941939.2016.1240270

Cited by 28 publications

(27 citation statements)

References 17 publications

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“…That is why clinicians usually proceed with repeat biopsies. Therefore, the only way to reach a definitive diagnosis is by obtaining a biopsy [11]. Moreover, histology is a must as radiographic images are nonspecific [3].…”

Section: Discussionmentioning

confidence: 99%

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Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

Halim

Uthman

Rammal

et al. 2018

Case Reports in Rheumatology

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Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease that affects women of childbearing age with a history of breastfeeding. It usually presents as an enlarging breast mass that can greatly mimic breast cancer. Moreover, it does not have a specific radiographic finding, so the only way to reach a definitive diagnosis is by core biopsy and histology. Furthermore, a consensus regarding the best treatment modality has not been reached yet. In this report, we describe the cases of two patients who suffered from this disease, and to our knowledge, such a report is the first of its kind to address this topic in this region. Therefore, because of its uncommon nature and obscure presentation, we hereby report two cases of idiopathic granulomatous mastitis. The clinical presentation, treatment, and pathological findings are described, and a literature review on idiopathic granulomatous mastitis will be reported.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, IL-33 levels if used in conjugation with ultrasound and mammography can favor a diagnosis of IGM. However, the only method for definitive diagnosis at this point remains the use of biopsy [11].…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

Halim

Uthman

Rammal

et al. 2018

Case Reports in Rheumatology

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“…Genotyping analysis showed that there was no significant change in the frequencies of genotypes and alleles at SNPs rs3212227 and rs1929992 in IL-12b and IL-33 genes, respectively, and that serum levels of IL-12 and IL-33 were not influenced by these genotypes in both patients and healthy controls [ 61 ]. Finally, serum IL-33 was used in differential diagnoses of idiopathic granulomatous mastitis (IGM) and breast cancer [ 62 ]. IL-33 was significantly higher in IGM patients as compared to breast cancer patients.…”

Section: The Role Of Il33/st2 In Tumorigenesismentioning

confidence: 99%

“…Although, serum levels of sST2 were significantly lower in IGM patients, there was no significant difference between procalcitonin levels, a clinical marker of inflammation and infection. Thus, serum levels of IL-33 and sST2 could serve as differential diagnostic markers between IGM and breast cancer along with radiological and pathological examinations [ 62 ]. In summary, the IL-33/ST2 pathway promotes progression of breast cancer in both pre-clinical and clinical studies mostly through the recruitment of inflammatory cells that enhance tumor growth, invasiveness, and angiogenesis.…”

Section: The Role Of Il33/st2 In Tumorigenesismentioning

confidence: 99%

The Role of IL-33/ST2 Pathway in Tumorigenesis

Larsen

Minaya

Vaish

et al. 2018

IJMS

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Cancer is initiated by mutations in critical regulatory genes; however, its progression to malignancy is aided by non-neoplastic cells and molecules that create a permissive environment known as the tumor stroma or microenvironment (TME). Interleukin 33 (IL-33) is a dual function cytokine that also acts as a nuclear factor. IL-33 typically resides in the nucleus of the cells where it is expressed. However, upon tissue damage, necrosis, or injury, it is quickly released into extracellular space where it binds to its cognate receptor suppression of tumorigenicity 2 (ST2)L found on the membrane of target cells to potently activate a T Helper 2 (Th2) immune response, thus, it is classified as an alarmin. While its role in immunity and immune-related disorders has been extensively studied, its role in tumorigenesis is only beginning to be elucidated and has revealed opposing roles in tumor development. The IL-33/ST2 axis is emerging as a potent modulator of the TME. By recruiting a cohort of immune cells, it can remodel the TME to promote malignancy or impose tumor regression. Here, we review its multiple functions in various cancers to better understand its potential as a therapeutic target to block tumor progression or as adjuvant therapy to enhance the efficacy of anticancer immunotherapies.

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“…6 The levels of inflammation biomarkers such as interleukin-33 (IL- 33) and soluble ST2 receptor of IL-33 (sST2) were significantly higher in women with IGM compared with controls. 7 In addition, based on the result of a nested case-control study on 667 women with BPBD and 1321 controls, serum levels of C-reactive protein (CRP) were positively and adiponectin were inversely associated with the early stages of BPBD. 8 In addition to the role of inflammation, other various causes such as endogenous hormones, oral contraceptives, estrogen replacement therapy and dietary intake during adolescence are important factors in the development of BBD.…”

Section: Introductionmentioning

confidence: 99%

<p>Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Benign Breast Diseases in a Case–Control Study</p>

Aghababayan

Mobarakeh

Qorbani

et al. 2020

JIR

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Purpose: Dietary inflammatory index (DII) is a new tool for assessing the inflammatory potential of diet. Since there is no study that has investigated the association of DII and benign breast diseases (BBD), the aim of our study was to compare DII scores in patients with and without BBD. Methods: One hundred and eleven (111) subjects with BBD and 104 healthy women attending the Iranian Center for Breast Cancer affiliated with the Academic Center for Education, Culture and Research were enrolled in a case-control study. Dietary data collected using a 168-item validated food frequency questionnaire (FFQ). Energy-adjusted DII was calculated based on FFQ. Socio demographic data were collected by interview. In addition, physical activity was measured by the International Physical Activity Questionnaire (IPAQ). Weight, height and waist circumference were also measured. Results: After adjustment for multiple confounding variables, participants at the highest tertile of DII had increased OR for BBD (OR=1.7, 95% CI=0.75-3.95) (P-trend =0.04). Conclusion: The increased chance of BBD was suggested with a higher consumption of diets with inflammatory potential. However, this result should be interpreted with caution as OR was not statistically significant. Interventional studies are warranted to elucidate the role of inflammatory diets in the development of BBD.

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The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

Abstract: The results of our study suggest that measurement of IL-33 and its receptor sST2 levels, alongside radiological studies can help distinguishing IGM from BC. Findings of our study need to be supported with additional studies.

Cited by 28 publications

References 17 publications

Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

Idiopathic Granulomatous Mastitis Presenting as a Breast Pseudotumor: Case Reports with Review of the Literature

The Role of IL-33/ST2 Pathway in Tumorigenesis

<p>Higher Dietary Inflammatory Index Scores are Associated with Increased Odds of Benign Breast Diseases in a Case–Control Study</p>

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