The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

DH, AbdelKader

doi:10.15406/japlr.2016.02.00007

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…The piezoelectric principle of some materials has been researched in the field of drug delivery; for instance, in the fabrication of micropumps to treat diseases such as diabetes, with direct effects on tissue healing [128][129][130][131][132], or in the development of hybrid composite scaffolds made out of piezoelectrically active materials [133][134][135].…”

Section: Piezoelectrically Active Materials For Drug Deliverymentioning

confidence: 99%

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon

Magaz

Balint

et al. 2018

Advanced Drug Delivery Reviews

130

112

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Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment. This review focuses on current state-of-the-art research in electroactive-based materials towards the delivery of drugs and other therapeutic signalling agents for wound care treatment. Future directions and current challenges for developing effective electroactive approach based therapies for wound care are discussed.

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Section: Piezoelectrically Active Materials For Drug Deliverymentioning

confidence: 99%

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Tandon

Magaz

Balint

et al. 2018

Advanced Drug Delivery Reviews

130

112

View full text Add to dashboard Cite

show abstract

“…It is suggested that this is associated with increased expression of the integrin α3β1 in keratinocytes and an increase in the levels of LN332 (Laminin 332). Insulin may act as a chemoattractant and mitogenic agent for cells that are involved in wound healing [6,7]. The insulin receptors IRS-1 (insulin receptor substrate-1), IRS-2 (insulin receptor substrate-2), ERK (extracellular signal-regulated protein kinase), and Akt (serine-threonine kinase) are significantly expressed in the damaged wound vs. the intact skin, indicating a potential role for the insulin signaling pathway in the wound repair process.…”

Section: Introductionmentioning

confidence: 99%

“…A promising direction is the development of a semi-solid form of insulin, e.g., as adhesive films or hydrogel. The use of bioadhesive hydrogels may increase the prolonging residence time of insulin at the site of application and reduce the frequency of administration [7]. Carriers that deliver insulin in its free form use the location of the insulin receptor located on the plasma membrane [12].…”

Section: Introductionmentioning

confidence: 99%

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

et al. 2021

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Insulin loaded to the polymer network of hydrogels may affect the speed and the quality of wound healing in diabetic patients. The aim of our research was to develop a formulation of insulin that could be applied to the skin. We chose hydrogels commonly used for pharmaceutical compounding, which can provide a form of therapy available to every patient. We prepared different gel formulations using Carbopol® UltrezTM 10, Carbopol® UltrezTM 30, methyl cellulose, and glycerin ointment. The hormone concentration was 1 mg/g of the hydrogel. We assessed the influence of model hydrogels on the pharmaceutical availability of insulin in vitro, and we examined the rheological and the texture parameters of the prepared formulations. Based on spectroscopic methods, we evaluated the influence of model hydrogels on secondary and tertiary structures of insulin. The analysis of rheograms showed that hydrogels are typical of shear-thinning non-Newtonian thixotropic fluids. Insulin release from the formulations occurs in a prolonged manner, providing a longer duration of action of the hormone. The stability of insulin in hydrogels was confirmed. The presence of model hydrogel carriers affects the secondary and the tertiary structures of insulin. The obtained results indicate that hydrogels are promising carriers in the treatment of diabetic foot ulcers. The most effective treatment can be achieved with a methyl cellulose-based insulin preparation.

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“…Insulin is a peptide hormone and regulate blood glucose level. On the other hand, some studies show that insulin application accelerates wound healing, such as facilitates monocytes/macrophages chemotaxis, pinocytosis/phagocytosis, anabolic protein metabolism, local glucose level and secretion of infl ammatory and growth mediators [5][6][7] . In this case report, we aimed to present the positive eff ects of topical insulin in the treatment of a non-healed skin wound.…”

Section: Introductionmentioning

confidence: 99%

Bir Vervet Maymununun Gluteal Bölgesindeki Maddi Kayıplı Deri Yarasının Topikal İnsülin İle Sağaltımı

GÜLTEKİN¹,

ULUKAN²,

Özdemir³

et al. 2019

Kafkas Univ Vet Fak Derg

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In a female vervet monkey brought to our hospital with the complaint of anaphylactic shock depending on snake bite, a gangrenous wound was detected in right gluteal region and traditional local cicatrizing and epithelizing pomade application and systemic treatment were performed for 10 days. As no signs of epithelization and shrinkiage was observed during this treatment, a new treatment protocol was started with topical insulin pomade. It was determined that epithelization started on the 4 th days and completely recovered on the 46th days of the treatment and 30 days after the completion of topical insulin treatment the wound region was became hairy. It was concluded that topical treatment with insulin pomade had positive effects on delayed secondary wound healing in vervet monkeys whom their cutaneous trunci muscle (M. panniculus carnosus) responsible for wound contraction was not functional. ÖzHastanemize yılan ısırığına bağlı anaflaktik şok şikayeti ile getirilen dişi vervet maymununda, sağ gluteal bölgede gangrenli deri yarası tespit edildikten sonra 10 gün boyunca geleneksel lokal sikatrizan ve epitelizan pomat uygulamaları ve sistemik sağaltım yapıldı. Yarada epitelizasyon ve küçülmenin hiç gözlenmemesi üzerine topikal insulin pomat uygulamasına geçildi. Uygulamanın 4. gününde epitelizasyonun başladığı, 46. günde tamamlandığı, topikal insulin sağaltımının kesilmesinden sonra 30. günde ise epitelizasyon bölgesinin tüylendiği gözlendi. Sonuç olarak, yaranın kontraksiyonla küçülmesini sağlayan cutaneous trunci (M. panniculus carnosus) kasının non-human primatlarda fonksiyonel olmadığı, topikal insülin pomat uygulamalarının gecikmiş sekunder yara iyileşmesinde pozitif katkıları olduğu gözlendi.

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The Role of Insulin in Wound Healing Process: Mechanism of Action and Pharmaceutical Applications

Cited by 8 publications

References 42 publications

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

Bir Vervet Maymununun Gluteal Bölgesindeki Maddi Kayıplı Deri Yarasının Topikal İnsülin İle Sağaltımı

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