The role of inflammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus

Ray, Argho; Huisman, M. V.; Tamsma, Jouke T.; Asten, J. van; Bingen, BO; Broeders, E.A.B.J.; Hoogeveen, E.S.; Hout, Fabienne M.A. van; Kwee, V.A.; Laman, B.; Malgo, F.; Mohammadi, Mahmoud; Nijenhuis, MV; Rijkée, M.; Tellingen, M.M. van; Tromp, Mirjam; Tummers, Quirijn R.J.G.; Vries, Lina de

doi:10.1016/j.ejim.2008.07.008

Cited by 64 publications

(41 citation statements)

References 65 publications

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“…There is a direct association between inflammatory response and pathogenesis of atherosclerosis among patients with diabetes [22]. Dietary interventions can be used as a therapeutic approach to modify the inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study

et al. 2015

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“…Atherosclerosis is an inflammatory disease that is mediated by monocyte derived macrophages which accumulate in arterial plaques and become activated to release cytokines that cause tissue damage [88]. Atherosclerotic plaques in type II diabetic patients have increased inflammatory properties and worse cardiovascular outcomes than plaques observed in non-diabetic subjects [89]. We reported that systemic inflammation precedes either hyperglycemia or oxidative stress in db/db mice [90].…”

Section: Diabetes Inflammation and Anti-inflammatory Effect Of Ementioning

confidence: 99%

“…As evidence accumulates favoring the role of inflammation during the different phases of atherosclerosis, it is likely that markers of inflammation such as high-sensitivity C-reactive protein (hs-CRP) may be increasingly used to provide additional insights on the biological status of atherosclerotic lesions. Several studies have shown that CRP and proinflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis- α (TNF- α ), are elevated in type II diabetic patients [89, 91]. CRP is considered to be an independent predictor of cardiovascular events and of the outcome of acute coronary syndromes [92].…”

Section: Diabetes Inflammation and Anti-inflammatory Effect Of Ementioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Exercise in Diabetic Patients

Golbidi

Badran

Laher

2012

Experimental Diabetes Research

111

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Diabetes is a chronic metabolic disease which is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action. The key roles of oxidative stress and inflammation in the progression of vascular complications of this disease are well recognized. Accumulating epidemiologic evidence confirms that physical inactivity is an independent risk factor for insulin resistance and type II diabetes. This paper briefly reviews the pathophysiological pathways associated with oxidative stress and inflammation in diabetes mellitus and then discusses the impact of exercise on these systems. In this regard, we discuss exercise induced activation of cellular antioxidant systems through “nuclear factor erythroid 2-related factor.” We also discuss anti-inflammatory myokines, which are produced and released by contracting muscle fibers. Antiapoptotic, anti-inflammatory and chaperon effects of exercise-induced heat shock proteins are also reviewed.

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“…The increased risk of cardiovascular events appears to be related to a large number of factors, including hyperactivation of the reninangiotensin-aldosterone system (RAAS), 1 direct vascular damage caused by hyperglycemia in diabetics, 2 systemic subclinical inflammation, 3 aberrant modulation of adipokine synthesis 4 and a pathological increase in the vascular remodeling rate. 5 Angiotensin II (Ang II), the major actor of the RAAS, acts through two receptor subtypes: Ang II type 1 (AT1R) and type 2 (AT2R).…”

Section: Introductionmentioning

confidence: 99%

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

et al. 2010

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We planned a randomized, double blind clinical trial to evaluate whether an antihypertensive intervention at the proximal or distal level of the renin-angiotensin-aldosterone system could have different effects on a broad range of innovative cardiovascular risk biomarkers. A total of 288 hypertensive Caucasian patients (115 men and 113 women), aged X18 years, were enrolled in this study. They were randomized to take losartan 50 mg per day or ramipril 5 mg per day for 1 month and titrated up to 100 mg per day and 10 mg per day for 13 months, respectively. At baseline, 1, 2 and 14 months after therapy initiation, we evaluated the following parameters: body weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), M-value, adiponectin (ADN), resistin (r), retinol binding protein-4 (RBP-4), visfatin, vaspin, high-sensitivity C-reactive protein (Hs-CRP), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). No variation of body weight, BMI, FPG or vaspin was obtained with either treatment. We recorded a similar improvement in SBP, DBP and Hs-CRP with both treatments; however, losartan also increased M-value, ADN and visfatin, whereas ramipril did not. Furthermore, losartan decreased r, RBP-4, MMP-2 and MMP-9, whereas ramipril did not have any effect on these parameters. In conclusion, we observed that short-term treatment with losartan improved several metabolic parameters (M-value, ADN, RBP-4, r and visfatin) and decreased vascular remodeling biomarkers (MMP-2 and MMP-9) in hypertensive subjects, whereas ramipril did not.

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The role of inflammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus

Cited by 64 publications

References 65 publications

Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study

Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study

Antioxidant and Anti-Inflammatory Effects of Exercise in Diabetic Patients

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

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