2014
DOI: 10.24015/japm.2014.0015
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The Role of Inflammation in Postoperative Cognitive Dysfunction

Abstract: Aim of review:Postoperative cognitive dysfunction (POCD) is a common complication following surgery, especially in the elderly population. Surgery exposes patients to extensive trauma, blood loss, and tissue injury, all of which contribute to an inflammatory response. In recent years, inflammation has been shown to be a key contributor to the pathogenesis of cognitive decline and neuroinflammatory processes, both in animal models and initial clinical observations. Method: We review the recent literatures on th… Show more

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Cited by 2 publications
(2 citation statements)
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References 85 publications
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“…Its effects on behavior have been well documented (Dantzer et al, 1998 ), but the mechanisms underlying cognitive impairments after endotoxemia are not fully understood. Inflammatory molecules can access the CNS through different immune-to-brain mechanisms, both blood-borne and neuronal (Capuron and Miller, 2011 ; Xu et al, 2014 ). After LPS exposure, we found a significant increase in systemic pro-inflammatory cytokines, including TNF-α and IL-1β, which initiate a pro-inflammatory response that affects long-term CNS function.…”
Section: Discussionmentioning
confidence: 99%
“…Its effects on behavior have been well documented (Dantzer et al, 1998 ), but the mechanisms underlying cognitive impairments after endotoxemia are not fully understood. Inflammatory molecules can access the CNS through different immune-to-brain mechanisms, both blood-borne and neuronal (Capuron and Miller, 2011 ; Xu et al, 2014 ). After LPS exposure, we found a significant increase in systemic pro-inflammatory cytokines, including TNF-α and IL-1β, which initiate a pro-inflammatory response that affects long-term CNS function.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, the timing of administration may be another factor. Synaptic long-term potentiation (LTP) is the cell model of central sensitization, and is associated with the degree of pain (45) and postoperative cognitive decline (46). Low dose of ketamine could prevent the development of long-term potentiation, but couldn't influence its maintenance (47).…”
mentioning
confidence: 99%