The Role of Inflammation and Infection in Preterm Birth

Bastek, Jamie A.; Gómez, Luis M.; Elovitz, Michal A.

doi:10.1016/j.clp.2011.06.003

Cited by 127 publications

(89 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflammation, whether or not related to infection, is one of the best-studied pathways in humans and animal models of PTB. Infection and inflammation are particularly prevalent in early spontaneous PTB: chorioamnionitis is implicated in >85% of deliveries occurring before 28 weeks of gestation (10,37). The consequences of intrauterine infection include uterine contractions, cervical dilatation, and weakening of the chorioamniotic membrane.…”

Section: Established Pathways Implicated In Term and Preterm Parturitionmentioning

confidence: 99%

Prevention of preterm birth: Harnessing science to address the global epidemic

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Established Pathways Implicated In Term and Preterm Parturitionmentioning

confidence: 99%

Prevention of preterm birth: Harnessing science to address the global epidemic

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Our current understanding of contributing factors for PTB is mostly limited to inflammation and therefore the focus has mainly been on inflammatory markers. [8][9][10] Biomarker discovery has progressed rather dramatically and improvements have been achieved in sensitivity and reproducibility of data. High-throughput technologies, a major progress in advancing targeted biomarker quantitation and validation, from standard enzyme-linked immunosorbent assays (ELISAs) to bead-based assays have improved our PTB biomarker knowledge base.…”

Section: Introductionmentioning

confidence: 99%

Amniotic Fluid Metabolomic Analysis in Spontaneous Preterm Birth

et al. 2014

View full text Add to dashboard Cite

Objective: To identify metabolic changes associated with early spontaneous preterm birth (PTB; <34 weeks) and term births, using high-throughput metabolomics of amniotic fluid (AF) in African American population. Method: In this study, AF samples retrieved from spontaneous PTB (<34 weeks [n ¼ 25]) and normal term birth (n ¼ 25) by transvaginal amniocentesis at the time of labor prior to delivery were subjected to metabolomics analysis. Equal volumes of samples were subjected to a standard solvent extraction method and analyzed using gas chromatography/mass spectrometry (MS) and liquid chromatography/MS/MS. Biochemicals were identified through matching of ion features to a library of biochemical standards. After log transformation and imputation of minimum observed values for each compound, t test, correlation tests, and false discovery rate corrections were used to identify differentially regulated metabolites. Data were controlled for clinical/demographic variables and medication during pregnancy. Results: Of 348 metabolites measured in AF samples, 121 metabolites had a gestational age effect and 116 differed significantly between PTB and term births. A majority of significantly altered metabolites could be classified into 3 categories, namely, (1) liver function, (2) fatty acid and coenzyme A (CoA) metabolism, and (3) histidine metabolism. The signature of altered liver function was apparent in many cytochrome P450-related pathways including bile acids, steroids, xanthines, heme, and phase II detoxification of xenobiotics with the largest fold change seen with pantothenol, a CoA synthesis inhibitor that was 8-fold more abundant in PTB. Conclusion: Global metabolic profiling of AF revealed alteration in hepatic metabolites involving xenobiotic detoxification and CoA metabolism in PTB. Maternal and/or fetal hepatic function differences may be developmentally related and its contribution PTB as a cause or effect of PTB is still unclear.

show abstract

“…are mostly considered as commensals of the lower genital tract [3], intrauterine infection during pregnancy is associated with adverse pregnancy outcome and neonatal morbidity [5,6,7,8]. The most common pathway of bacteria invading the intrauterine compartment is an ascending infection from the vagina [9]. …”

Section: Introductionmentioning

confidence: 99%

First Trimester Vaginal <b><i>Ureaplasma</i></b> Biovar Colonization and Preterm Birth: Results of a Prospective Multicenter Study

Rittenschober-Böhm¹,

Waldhoer²,

Schulz³

et al. 2017

Neonatology

View full text Add to dashboard Cite

Background: While there is a proven association of upper genital tract Ureaplasma infection during pregnancy with adverse pregnancy outcome, the effect of vaginal Ureaplasma colonization on preterm delivery has been controversially debated. Objectives: We hypothesized that women with isolation of vaginal U. parvum but not U. urealyticum are at increased risk for spontaneous preterm birth (SPB) compared to women with negative results. Methods: A vaginal swab taken between 12 and 14 weeks of gestation was analyzed for the presence of Ureaplasma biovars by PCR in 4,330 pregnant women. Results: Of the study cohort, 37% were positive for U. parvum, 5.9% for U. urealyticum, and 3.1% for both. The rates of SPB were 10.4% (OR 1.7, 95% CI 1.3, 2.2, p < 0.001) and 8.9% (OR 1.4, 95% CI 0.9, 2.3, p = 0.193) in the groups with isolation of U. parvum and U. urealyticum, respectively, compared to 6.4% in the group with negative PCR results. Multiple logistic regression and interaction analyses showed that vaginal colonization with U. parvum but not U. urealyticum was a statistically significant risk factor for SPB (adjusted OR 1.6, 95% CI 1.2, 2.1, p < 0.001), independent of other risk factors such as bacterial vaginosis and history of SPB. Conclusion: Our study demonstrates a statistically significant and independent association between first-trimester vaginal colonization with U. parvum and subsequent SPB.

show abstract

The Role of Inflammation and Infection in Preterm Birth

Cited by 127 publications

References 164 publications

Prevention of preterm birth: Harnessing science to address the global epidemic

Prevention of preterm birth: Harnessing science to address the global epidemic

Amniotic Fluid Metabolomic Analysis in Spontaneous Preterm Birth

First Trimester Vaginal <b><i>Ureaplasma</i></b> Biovar Colonization and Preterm Birth: Results of a Prospective Multicenter Study

Contact Info

Product

Resources

About