The role of impulsivity and perceived availability on cue-elicited craving for alcohol in social drinkers

Papachristou, Harilaos; Nederkoorn, Chantal; Corstjens, Jan; Jansen, Anita

doi:10.1007/s00213-012-2747-4

Cited by 26 publications

(24 citation statements)

References 36 publications

(76 reference statements)

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“…For example, greater delay discounting (MacKillop et al 2010) and reduced reflection impulsivity (tendency to gather and evaluate information before making a decision) correlates with craving (Joos et al 2013), while impaired response inhibition (stop signal task) moderates alcohol cue-induced craving (Papachristou et al 2012). The current paper is the first to investigate associations between alcohol-induced risk taking and priming but we would suggest that this is a fruitful area of research.…”

Section: Discussionmentioning

confidence: 99%

Alcohol-induced risk taking on the BART mediates alcohol priming

et al. 2013

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RationaleHazardous drinking has been associated with risk taking and alcohol priming effects. However, the potential relationship between risk taking and priming has not been investigated. The Balloon Analogue Risk Task (BART) is a behavioural measure of risk taking which appears to be associated with drinking behaviour. However, alcohol's acute effects on BART performance are not clear, and the potentially mediating effect of alcohol-induced risk taking on priming has not been tested.ObjectivesTo assess the effects of a priming dose of alcohol on BART performance; to determine the predictive utility of the BART on drinking habits; and to identify whether alcohol-induced risk taking mediates alcohol priming (urge to drink).MethodsA total of 142 participants provided data on drinking habits and trait-like impulsivity and sensation seeking. The BART was then completed after consuming alcohol (0.6 g/kg) or placebo (between-subjects design). Baseline and post-drink measures of alcohol urge were also taken.ResultsAlcohol consumption increased urge to drink (priming) and risk taking on the BART. In the alcohol group only, risk taking on the BART predicted unique variance in weekly alcohol consumption and bingeing. Mediation analysis showed that risk taking following alcohol consumption mediated alcohol priming.ConclusionsThis is the first study to show that alcohol acutely increases risk taking on the BART. Results suggest that social drinkers susceptible to alcohol-induced risk taking may be more likely to drink excessively, perhaps due to increased urge to drink (priming).Electronic supplementary materialThe online version of this article (doi:10.1007/s00213-013-3377-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Alcohol-induced risk taking on the BART mediates alcohol priming

et al. 2013

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“…One key difference between that study and ours is that there was no measure of alcohol self-administration to compare with our bogus taste test for food. The alcoholics’ knowledge that alcohol was not available during the sessions could have led either to more craving (MacKillop and Lisman 2005) or less craving (Papachristou et al 2012), but we cannot readily say how it might have suppressed an effect of pexacerfont.…”

Section: Discussionmentioning

confidence: 99%

Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving

et al. 2016

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Rationale In rodents, antagonism of receptors for corticotropin-releasing factor (CRF) blocks stress-induced reinstatement of drug or palatable food seeking. Objective To test anticraving properties of the CRF1 antagonist pexacerfont in humans. Methods We studied stress-induced eating in people scoring high on dietary restraint (food preoccupation and chronic unsuccessful dieting) with body-mass index (BMI) >22. In a double-blind, between-groups trial, 31 “restrained” eaters were stabilized on either pexacerfont (300 mg/day for 7 days, then 100 mg/day for 21 days) or placebo. On day 15, they underwent a math-test stressor; during three subsequent visits, they heard personalized craving-induction scripts. In each session, stress-induced food consumption and craving were assessed in a bogus taste test and on visual analog scales. We used digital video to monitor daily ingestion of study capsules and nightly rating of food problems/preoccupation on the Yale Food Addiction Scale (YFAS). Results The study was stopped early due to an administrative interpretation of US federal law, unrelated to safety or outcome. The bogus taste tests suggested some protective effect of pexacerfont against eating after a laboratory stressor (reffect = 0.30, 95 % CL = −0.12, 0.63, Bayes factor 11.30). Similarly, nightly YFAS ratings were lower with pexacerfont than placebo (reffect = 0.39, CI 0.03, 0.66), but this effect should be interpreted with caution because it was present from the first night of pill ingestion, despite pexacerfont’s slow pharmacokinetics. Conclusions The findings may support further investigation of the anticraving properties of CRF1 antagonists, especially for food.

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“…Furthermore, elevated disinhibition in substance users may have a direct effect on drug-seeking behavior, 61 but it may also have a more indirect effect by causing an exaggerated response to information about imminent drug availability. 67 However, we must be clear that the evidence described in this review cannot provide a complete account of addiction. Other processes such as opponent processes 71,72 that may ultimately lead to hedonic homeostatic dysregulation are also likely to play an important role.…”

Section: Synthesis and Theoretical Implicationsmentioning

confidence: 97%

The role of anticipation in drug addiction and reward

Jedras¹,

Jones²,

Field

2013

NAN

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Addiction is a chronically relapsing disorder, and substance users frequently relapse when they encounter opportunities to use drugs. In this paper, we review evidence regarding the psychological response to anticipation of imminent drug availability, its neural substrates, and its relationship to other phenomena implicated in addiction. Naturalistic and laboratory studies indicate that drug anticipation increases cue-provoked craving and attentional biases for drug-related cues. As predicted by existing theoretical models, these effects reflect hypervaluation of drugs that are perceived as available for consumption, which is linked to activation of the dorsolateral prefrontal cortex that, in turn, innervates subcortical regions associated with reward processing. Drug expectancy is necessary for the formation of conditioned responses to drug-related cues and it modulates the strength of conditioned responses. Furthermore, the role of impulsivity in addiction can be understood in terms of its interaction with the response to imminent drug availability. These results have a number of implications for the treatment of addiction, ranging from government policies that restrict the perceived availability of drugs to novel biological and psychological interventions that could blunt the response to signals of drug availability.

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The role of impulsivity and perceived availability on cue-elicited craving for alcohol in social drinkers

Cited by 26 publications

References 36 publications

Alcohol-induced risk taking on the BART mediates alcohol priming

Alcohol-induced risk taking on the BART mediates alcohol priming

Effect of the CRF1-receptor antagonist pexacerfont on stress-induced eating and food craving

The role of anticipation in drug addiction and reward

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