The role of IL-6, IL-10, TNF-α and PD-1 expression on CD4 T cells in atrial fibrillation

Bai, Wen; Liu, Zhiqiang; He, Pengyi; Muhuyati,

doi:10.1016/j.heliyon.2023.e18818

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…The PPI network analysis indicated that TNF and IL6 were key genes, cellular response to chemical stress and response to oxidative stress were key biological processes. The relationship between IL6, TNF and AF had been validated [51][52] and that pointed that the mechanism of C-C,N,S treating AF maybe related to in ammation. Then the gene speci c expression analysis provided a possibilities that C-C,N,S can regulate the in ammation occurred in cardiac myocytes, adipocytes and endothelial which maybe generated by liver diseases and heart diseases [53][54][55] .…”

Section: Discussionmentioning

confidence: 96%

C-C,N,S treats atrial fibrillation through regulating inflammatory procession: a study of network pharmacology research and gene set enrichment analysis validation

Yang,

Wang,

2023

Preprint

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Triangle drug combination of Citrus medica L.var.sarcodactylis Swingle, Naradostachys jatamansi DC. and Salvia miltiorrhiza Bge. (C-C,N,S) is usually appeared in atrial fibrillation-treating (AF) decoction and has good clinical effects. However, the core pathological process and mechanism of C-C,N,S intervening AF is unclear. So we intend to use network pharmacology and gene set enrichment analysis to explore the potential mechanism. We detected all compounds of C-C,N,S from CNKI database, predicted its bioactive compounds and potential anti-AF targets from related online platforms and databases. Then through PPI network, gene expression analyses, GO and KEGG pathway enrichment analysis on anti-AF targets, we determined the potential mechanism of C-C,N,S treating AF. Finally we used gene set enrichment analysis (GSEA) to validate the therapeutic effect of C-C,N,S. In conclusion, the therapeutic effect of C-C,N,S treating AF was focused on anti-inflammation. C-C,N,S can regulate inflammatory process and inhibit atrial remodeling and fibrosis through regulating TNF signaling pathway, IL-17 signaling pathway (MAPK signaling involved in) and PI3K-Akt signaling pathway. Some genes regulated by specific herbal medicine explained reason of the combination.

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Section: Discussionmentioning

confidence: 96%

C-C,N,S treats atrial fibrillation through regulating inflammatory procession: a study of network pharmacology research and gene set enrichment analysis validation

Yang,

Wang,

2023

Preprint

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“…Meanwhile, another study in a large cohort of postmenopausal women found no significant association between IL-1β and the development of AF, although downstream effectors, CRP and IL-6, were associated with the development of AF [ 35 ]. Another study showed that high levels of IL-6, IL-10, and TNF-α were associated with the progression of paroxysmal or chronic AF [ 36 ]. The importance of systemic inflammation was exemplified in a study in which lipopolysaccharide (LPS) induced the suppression of the L-type calcium-channel gene expression [ 37 ].…”

Section: Factors Associated With Developing Atrial Fibrillation In Co...mentioning

confidence: 99%

Early Detection of Atrial Fibrillation in Chronic Obstructive Pulmonary Disease Patients

Kotlyarov,

Lyubavin

2024

Medicina

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Atrial fibrillation (AF) is an important medical problem, as it significantly affects patients’ quality of life and prognosis. AF often complicates the course of chronic obstructive pulmonary disease (COPD), a widespread disease with heavy economic and social burdens. A growing body of evidence suggests multiple links between COPD and AF. This review considers the common pathogenetic mechanisms (chronic hypoxia, persistent inflammation, endothelial dysfunction, and myocardial remodeling) of these diseases and describes the main risk factors for the development of AF in patients with COPD. The most effective models based on clinical, laboratory, and functional indices are also described, which enable the identification of patients suffering from COPD with a high risk of AF development. Thus, AF in COPD patients is a frequent problem, and the search for new tools to identify patients at a high risk of AF among COPD patients remains an urgent medical problem.

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Based on TLR4-NLRP3-IL-1β inflammatory pathway: Comparison of necrotizing enterocolitis induced by different classes of antibiotic-induced Cronobacter sakazakii

Song,

Cheng,

Dong

et al. 2024

Food Bioscience

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The role of IL-6, IL-10, TNF-α and PD-1 expression on CD4 T cells in atrial fibrillation

Cited by 4 publications

References 38 publications

C-C,N,S treats atrial fibrillation through regulating inflammatory procession: a study of network pharmacology research and gene set enrichment analysis validation

C-C,N,S treats atrial fibrillation through regulating inflammatory procession: a study of network pharmacology research and gene set enrichment analysis validation

Early Detection of Atrial Fibrillation in Chronic Obstructive Pulmonary Disease Patients

Based on TLR4-NLRP3-IL-1β inflammatory pathway: Comparison of necrotizing enterocolitis induced by different classes of antibiotic-induced Cronobacter sakazakii

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