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The phytohormone abscisic acid (ABA) plays a vital role in plant development and response to environmental challenges, but the complex networks of ABA signaling pathways are poorly understood. We previously reported that a chloroplast protein, the magnesium-protoporphyrin IX chelatase H subunit (CHLH/ABAR), functions as a receptor for ABA in Arabidopsis thaliana. Here, we report that ABAR spans the chloroplast envelope and that the cytosolic C terminus of ABAR interacts with a group of WRKY transcription factors (WRKY40, WRKY18, and WRKY60) that function as negative regulators of ABA signaling in seed germination and postgermination growth. WRKY40, a central negative regulator, inhibits expression of ABA-responsive genes, such as ABI5. In response to a high level of ABA signal that recruits WRKY40 from the nucleus to the cytosol and promotes ABAR-WRKY40 interaction, ABAR relieves the ABI5 gene of inhibition by repressing WRKY40 expression. These findings describe a unique ABA signaling pathway from the early signaling events to downstream gene expression.

Air quality changes during the COVID-19 in YRD region are analyzed. • The WRF-CAMx modelling system is applied to investigate impact of lowered human activities on air quality changes. • Sources of the residual pollution are figured out for policy implications for future air pollution control.

We study the process e + e − → π + π − J/ψ at a center-of-mass energy of 4.260 GeV using a 525 pb −1 data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross section is measured to be (62.9 ± 1.9 ± 3.7) pb, consistent with the production of the Y (4260). We observe a structure at around 3.9 GeV/c 2 in the π ± J/ψ mass spectrum, which we refer to as the Zc(3900). If interpreted as a new particle, it is unusual in that it carries an electric charge and couples to charmonium. A fit to the π ± J/ψ invariant mass spectrum, neglecting interference, results in a mass of (3899.0 ± 3.6 ± 4.9) MeV/c 2 and a width 3 of (46 ± 10 ± 20) MeV. Its production ratio is measured to be R = σ(e + e − →π ± Zc(3900) ∓ →π + π − J/ψ)) σ(e + e − →π + π − J/ψ) = (21.5 ± 3.3 ± 7.5)%. In all measurements the first errors are statistical and the second are systematic. PACS numbers: 14.40.Rt, 14.40.Pq, 13.66.Bc Since its discovery in the initial-state-radiation (ISR) process e + e − → γ ISR π + π − J/ψ [1], and despite its subsequent observations [2][3][4][5], the nature of the Y (4260) state has remained a mystery. Unlike other charmonium states with the same quantum numbers and in the same mass region, such as the ψ (4040) A similar situation has recently become apparent in the bottomonium system above the BB threshold, where there are indications of anomalously large couplings between the Υ(5S) state (or perhaps an unconventional bottomonium state with similar mass, the Y b (10890)) and the π + π − Υ(1S, 2S, 3S) and π + π − h b (1P, 2P ) final states [14,15]. More surprisingly, substructure in these π + π − Υ(1S, 2S, 3S) and π + π − h b (1P, 2P ) decays indicates the possible existence of charged bottomoniumlike states [16], which must have at least four constituent quarks to have a non-zero electric charge, rather than the two in a conventional meson. By analogy, this suggests there may exist interesting substructure in the Y (4260) → π + π − J/ψ process in the charmonium region.In this Letter, we present a study of the process e + e − → π + π − J/ψ at a center-of-mass (CM) energy of √ s = (4.260± 0.001) GeV, which corresponds to the peak of the Y (4260) cross section. We observe a charged structure in the π ± J/ψ invariant mass spectrum, which we refer to as the Z c (3900). The analysis is performed with a 525 pb −1 data sample collected with the BESIII detector, which is described in detail in Ref. [17]. In the studies presented here, we rely only on charged particle tracking in the main drift chamber (MDC) and energy deposition in the electromagnetic calorimeter (EMC).The GEANT4-based Monte Carlo (MC) simulation software, which includes the geometric description of the BE-SIII detector and the detector response, is used to optimize the event selection criteria, determine the detection efficiency, and estimate backgrounds. For the signal process, we use a sample of e + e − → π + π − J/ψ MC events generated assuming the π + π − J/ψ is produced via Y (4260) decays, and using the...

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Th9 cells are a subset of CD4 + Th cells that produce the pleiotropic cytokine IL-9. IL-9/Th9 can function as both positive and negative regulators of immune response, but the role of IL-9/Th9 in tumor immunity is unknown. We examined the role of IL-9/Th9 in a model of pulmonary melanoma in mice. Lack of IL-9 enhanced tumor growth, while tumor-specific Th9 cell treatment promoted stronger antitumor responses in both prophylactic and therapeutic models. Th9 cells also elicited strong host antitumor CD8 + CTL responses by promoting Ccl20/Ccr6-dependent recruitment of DCs to the tumor tissues. Subsequent tumor antigen delivery to the draining LN resulted in CD8 + T cell priming. In agreement with this model, Ccr6 deficiency abrogated the Th9 cell-mediated antitumor response. Our data suggest a distinct role for tumor-specific Th9 cells in provoking CD8 + CTL-mediated antitumor immunity and indicate that Th9 cell-based cancer immunotherapy may be a promising therapeutic approach.

In New York State during winter 2004, there was a high incidence of influenza-like illness that tested negative both for influenza virus, by molecular methods, and for other respiratory viruses, by virus culture. Concern that a novel pathogen might be implicated led us to implement a new multiplex diagnostic tool. MassTag polymerase chain reaction resolved 26 of 79 previously negative samples, revealing the presence of rhinoviruses in a large proportion of samples, half of which belonged to a previously uncharacterized genetic clade. In some instances, knowledge of the detected viral and/or bacterial (co)infection could have altered clinical management.

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