This study examines the various explanations of the deliberative humanity, regarding a new gnoseology in the intellectual contexts of Giordano Bruno and Wang Yangming during the 15th and 16th centuries. In a similar way to Marsilio Ficino and Giordano Bruno for the European Renaissance, Wang Yangming is the enlightener among the representatives of Neo-Confucianism in early modern China. Each of these three takes an individual’s mind as the point of departure. They then modify the traditional theory of gnoseology, in search of the good and principle. Nevertheless, behind these similarities on the surface, the metaphorical and theoretical interpretations follow different directions. Marsilio Ficino translates hierarchic Platonism as a transcendent norm. Giordano Bruno and Wang Yangming, however, seem to liberate the individual’s humanity from the traditional norms of gnoseology. In their methodologies, they both have developed a generative gnoseology that differs from the orthodox pattern of knowledge in their respective traditions.