Yangmingism, a crucial component of Chinese Confucianism, has profoundly impacted the development of Eastern civilization throughout history and gained new significance within modern contexts. This study employs social network and GIS spatial analyses to investigate the spatio-temporal evolution and patterns of Yangmingism during the Ming and Qing dynasties. Conclusions drawn include: (1) Yangmingism spread during the Ming and Qing dynasties followed five phases (rise-peak-decline-revival-trough), consistent with general cultural diffusion processes. (2) The spatial structure of regions accepting Yangmingism changed from polycentric to localized ribbon-polycentric, then to monocentric, polycentric, and ultimately, fragmented distribution. Diffusion began with a point-axis structure along traffic routes, transitioned to a core-periphery spatial structure, and returned to a point-axis structure due to reduced diffusion potential energy. (3) Yangmingism diffusion exhibited distance decay characteristics, with the most extensive diffusion in the Han cultural region, primarily located within the middle and lower reaches of the Ganjiang River basin and the Yangtze River Delta. (4) Yangmingism diffusion reflected influences from local administrative hierarchies and cultural development. During the rise-to-peak phase, Yangmingism reached areas with higher administrative and cultural levels, while during the peak-to-decline phase, it disseminated from higher to lower hierarchy regions. (5) The spatial diffusion of Yangmingism is mainly relocation diffusion, followed by expansion diffusion. In the process of relocation diffusion, Yangmingism may reverse the diffusion from the “target regions” to the “source regions” due to the influence of the radiation of the high-ranking regions and the cultural innovation of the “target regions”.