The role of hypoxia in inflammatory disease (Review)

Biddlestone, John; Bandarra, Daniel; Rocha, Sónia

doi:10.3892/ijmm.2015.2079

Cited by 153 publications

(133 citation statements)

References 156 publications

Supporting

Mentioning

123

Contrasting

Unclassified

Order By: Relevance

“…When the regulatory mechanisms described above become aberrant, NF-κB results to be constitutively active or misregulated. For instance, NF-κB is chronically activated in several inflammatory diseases, such as arthritis, inflammatory bowel disease, asthma and many other pathological conditions, including cancers [11,12]. Here, we will discuss the role of NF-κB in cancer, focusing on how this transcription factor can be induced by hypoxia, and modulated by HIF, in a variety of tumour contexts.…”

Section: Nf-κb Subunits and Signalling Pathwaysmentioning

confidence: 99%

“…The intestinal lumen of a CRC patient is characterised by both inflammatory and hypoxic regions (reviewed in [11]). NF-κB is activated in CRC in response to inflammation, promoting tumorigenesis and cancer progression [111].…”

Section: Colorectal Cancermentioning

confidence: 99%

“…As previously stated, inflammation is a key player in tumour development and progression, therefore it is not surprising that chronic inflammatory diseases may predispose to cancer. One example is the Inflammatory Bowel Disease (IBD), a chronic intestinal disorder including Crohn's disease and ulcerative colitis [11]. Macrophages (TAMs).…”

Section: Crosstalk Between Hypoxia and Inflammation In Cancermentioning

confidence: 99%

See 2 more Smart Citations

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

D'Ignazio¹,

Batie²,

Rocha³

2017

Preprint

Self Cite

View full text Add to dashboard Cite

Cancer is often characterised by the presence of hypoxia and inflammation.Paramount to the mechanisms controlling cellular responses under such stress stimuli, are the transcription factor families of Hypoxia Inducible Factor (HIF) and NuclearFactor of kappa-light-chain-enhancer of activated B cells (NF-κB). Although, a detailed understating of how these transcription factors respond to their cognate stimulus is well established, it is now appreciated that HIF and NF-κB undergo extensive crosstalk, in particular in pathological situations such as cancer. Here, we focus on the current knowledge on how HIF is activated by inflammation and how NF-κB is modulated by hypoxia. We summarise the evidence for the possible mechanism behind this activation and how HIF and NF-κB function impacts cancer, focusing on colorectal, breast and lung cancer. We discuss possible new points of therapeutic intervention aiming to harness the current understanding of the HIF-NF-κB crosstalk.

show abstract

Section: Nf-κb Subunits and Signalling Pathwaysmentioning

confidence: 99%

Section: Colorectal Cancermentioning

confidence: 99%

Section: Crosstalk Between Hypoxia and Inflammation In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

D'Ignazio¹,

Batie²,

Rocha³

2017

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…These pathways regulate the production of ROS, the activation of pro-inflammatory cytokines, the uncontrolled cell proliferation, migration, metastasis and angiogenesis [123]. The absence of NF-kB has a negative effect on tumor progression in mouse models of colorectal cancer [124].…”

Section: Hif-1α and Inflammationmentioning

confidence: 99%

“…In colorectal cancer, NF-kB promotes tumorigenesis. Different signaling pathways drive its oncogenic role.The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model http://dx.doi.org/10.5772/intechopen.72318 215These pathways regulate the production of ROS, the activation of pro-inflammatory cytokines, the uncontrolled cell proliferation, migration, metastasis and angiogenesis [123]. The absence of NF-kB has a negative effect on tumor progression in mouse models of colorectal cancer [124].…”

mentioning

confidence: 99%

The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model

Tamamouna¹,

Pitsouli²

2018

Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics

View full text Add to dashboard Cite

The hypoxia-inducible factor-1α (HIF-1α) is an evolutionarily conserved transcription factor with prominent roles in the hypoxic response, cell survival, angiogenesis and cancer. HIF-1α functions as a sensor of molecular oxygen: in the presence of oxygen, it is degraded by the proteasome, whereas in reduced oxygen tensions, it heterodimerizes with the constitutively expressed HIF-1b subunit forming the functional HIF1 transcription factor, which enters the nucleus to control expression of hypoxia-inducible genes. Since HIF-1α has been found upregulated in several cancers, it has attracted a lot of clinical interest, because it represents an interesting candidate for pharmacological chemotherapy interventions. In this chapter, we discuss our current knowledge on the HIF1 transcription factors and their major roles in development, physiology, angiogenesis and cancer using examples of recent studies in the model organism Drosophila melanogaster. Given the striking functional conservation between the mammalian and fruit fly HIF-1α, we expect that future studies in the Drosophila model will not only expand our knowledge on the basic HIF1 biology, but they will also pinpoint conserved molecular regulators of HIF1 that might lead to the discovery of novel cancer therapeutics.Keywords: hypoxia, tumorigenesis, Warburg effect, metabolism, tracheogenesis, inflammation, Drosophila 1. HIF-1α in mammalian angiogenesis, inflammation and cancer Oxygen is required for survival of all animalsOxygen (O 2 ) is the main ingredient of the atmospheric air and is required for the survival of all living organisms. It is also present in the seas and oceans, and it is necessary for survival of all aquatic living organisms. Oxygen accumulated on Earth's atmosphere about 2.5 billion © 2018 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.years ago [1]. However, it was discovered only 245 years ago, by the chemist Carl Wilhelm Scheele [2]. Its main role in the survival of animals derives from its utilization during cellular respiration. Specifically, oxygen is involved in oxidative phosphorylation, the process that transfers the chemical energy stored in carbon bonds to the phosphate bonds of Adenosine Tri-Phosphate (ATP), which is the main energy carrier in all cell types of living organisms [3]. In addition, oxygen is the main component of ATP production, because it is the final electron acceptor of the respiratory chain. Oxygen-electron reaction leads to the release of reactive oxygen species (ROS), which, when accumulated, results in oxidative stress and eventually cell death [4,5]. Oxygen is necessary as an energy substrate, and the danger of oxidative damage needs to be kept at equilibrium. Therefore, oxygen homeostasis is critical for all cellular processes, and its intermittent supply resul...

show abstract

Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions

Smith

Jones

Johnson

et al. 2018

American J of Med Genetics Pt A

View full text Add to dashboard Cite

The purpose of this study was to analyze the risk of maternal autoimmune disease or associated treatments on infantile hemangiomas (IHs), a common benign vascular tumor in infants, and to better understand how maternal chronic inflammation may play a factor in the pathogenesis of these lesions. Eligible women from the United States and Canada who enrolled before 19 weeks' gestation and delivered at least one live born infant were recruited as part of the Organization of Teratology Information Specialists (OTIS) Autoimmune Disease in Pregnancy Project from 2004-2013. A total of 51/969 (5.3%) and 8/240 (3.3%) infants with IH were born to mothers with and without autoimmune disease, respectively (OR 1.61; 95%CI, 0.75-.44). The presence of ulcerative colitis (UC) in the mother was significantly associated with IH in the child (OR 3.46; 95%CI, 1.29-9.26). The five largest IH occurred within the autoimmune disease cohort and to women taking a biologic medication. These results imply that UC may be a risk factor for IH development, and that chronic inflammation may influence the development of these lesions. This potential link between IH and autoimmune disease warrants further investigation.

show abstract

The role of hypoxia in inflammatory disease (Review)

Cited by 153 publications

References 156 publications

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model

Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions

Contact Info

Product

Resources

About