Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

D'Ignazio, Laura; Batie, Michael; Rocha, Sónia

doi:10.20944/preprints201703.0240.v1

Cited by 60 publications

(42 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While HDAC function has been associated with both hypoxia and inflammation, no association of SIN3A function has been reported with both Hypoxia or NF-κB mediated signalling pathways. However, we had previously demonstrated that hypoxia and NF-κB are part of an intricate crosstalk D'Ignazio et al, 2016;D'Ignazio et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

Biddlestone

Batie

Shmakova

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

Abstract:The SIN3A-HDAC complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex, SINHCAF/FAM60A, links the SIN3A-HDAC co-repressor complex function to the hypoxia response. SINHCAF Chromatin Immunoprecipitation-sequencing and gene expression analysis reveal a signature associated with the activation of the hypoxia response. We show that SINHCAF specifically repress HIF 2α mRNA and protein expression resulting in functional cellular changes in in-vitro angiogenesis, and proliferation. Analysis of patient datasets demonstrates that SINHCAF and HIF 2α mRNA levels are inversely correlated and predict contrasting outcomes for patient survival in both colon and lung cancer. This relationship is also observed in a mouse model of colon cancer, indicating an evolutionary conserved mechanism. Our analysis reveals an unexpected link between SINHCAF and cancer cell signalling via regulation of the hypoxia response that is predictive of poor patient outcome.

show abstract

Section: Resultsmentioning

confidence: 99%

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

Biddlestone

Batie

Shmakova

et al. 2017

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…These transcription factors dictate the production of inflammatory molecules such as cytokines and chemokines, in addition to activating COX‐2. This leads to further activation and recruitment of leukocytes, triggers the inflammasome of tumour cells, and stimulates the production of other inflammatory mediators in a vicious cycle (D'Ignazio, Batie, & Rocha, ). (Poly)phenols including OOPC do modulate signal transduction and might potentially block cellular hyperproliferation.…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

View full text Add to dashboard Cite

In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

“…Hypoxia condition triggered hypoxia response signalling in the stem cells. Hypoxia induced factor-1 alpha subunit are known as unstable protein in the normoxia condition, but for adapting hypoxia environtment HIF-1α are stabilized and the HIF signalling pathways are activated (Ignazio et al, 2017). HIF signalling pathways could induce cell dedifferentiation (Wang et al, 2017b).…”

Section: Cellular Plasticityand Dedifferentiationmentioning

confidence: 99%

Cellullar Plasticity and Dedifferentiation: A Link Between Cancer Stem Cells, Hypoxia, Cell Injury, and Inflammation

Wijaya

2019

JSCRTE

View full text Add to dashboard Cite

Cellular plasticity is the concept of bidirectional dynamics change cells differentiation degree which involved in the regeneration, repair and tissue turnover along the organism livespan. Cellular plasticity and dedifferentiation process are well documented in the discovery of iPCSs by introducing several transcriptional factors known as Yamanaka factor to terminally differentiated somatic cells and reverted into pluripotent state as the ESCs. iPSCs are able to exhibit ESCs differentiation potential which could produce ectodermic, mesodermic, and endodermic cell lineage. In tumour biology, the tumour plasticity also have a similar regulation and play an imporant role for maintaining tumour integrity and survival, particularly in maintaining CSCs population. Various study of cellular plasticity regulation has shown that various factors are involved, in example hypoxia, cell injury, and inflammation. Cells respond to hypoxia, cell injury, and inflammation by chemoattractant which attract repair cells to homing towards injured sites. The homing mechanism of stem cells involved EMT to facilitates migration of stem cells towards injured sites, thus leading to tissue regeneration. On the other hand, cancer metastasis also showed a connection with EMT process. EMT which showed a change in cell properties are linked to dedifferentiation and hypoxia response. Hypoxia condition has been known to preserve and both normal stem cells and CSCs stemness. HIF which protected from degradation in hypoxia condition interact with DNA by binding to HRE. HRE activation trigger transcription of numerous signalling protein which involved in stemness, cell proliferation and survival. Therefore it is concluded that cell injury, hypoxia, and inflammation could programmed cells to undergo dedifferentiation process and involved in EMT regulations. CSCs which resides insides heterogeneous tumour cells population are though to be dynamicly regulate itself in the quietscent and active state through dedifferentiation like the normal stem cells. Understanding how CSCs regulates its active an quietscent state dynamics could provide an important information for novel CSCs targeted therapy development.

show abstract

Hypoxia and Inflammation in Cancer, Focus on HIF and NF-кB

Cited by 60 publications

References 104 publications

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival

An overview of the pharmacology of olive oil and its active ingredients

Cellullar Plasticity and Dedifferentiation: A Link Between Cancer Stem Cells, Hypoxia, Cell Injury, and Inflammation

Contact Info

Product

Resources

About