The role of hypervirulent Staphylococcus aureus infections in the development of deep vein thrombosis

Martin, Eric S.; Çevik, Cihan; Nugent, Kenneth

doi:10.1016/j.thromres.2012.06.013

Cited by 22 publications

(15 citation statements)

References 89 publications

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“…In our multiple logistic regression model, patients with pulmonary infection experienced an increased risk of DVT. A higher risky relevance of pulmonary infection with DVT was also demonstrated in other researches (14,15). A research on the psychiatric inpatients revealed that the average in-hospital incidence of DVT was up to 10%, while the DVT risk in the group with pulmonary infection was signi cantly increased (16).…”

Section: Analysis Of the Changes In Laboratory Variables When Dvt Detsupporting

confidence: 59%

Association of Clinical and Laboratory Variables with In-Hospital Incidence of Deep Vein Thrombosis in Patients with Acute Stroke: A Retrospective Study

Huang

Song

Peng

et al. 2020

Preprint

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Abstract Backgrounds: Deep vein thrombosis (DVT) is a serious complication in patients with acute stroke. Early prediction of DVT could enable physicians to perform a proper prevention strategy. We analyzed the association of clinical and laboratory variables with DVT to evaluate the risk of DVT in patients after stroke.Results: Acute stroke patients admitted to the Changsha Central Hospital between January 2016 and December 2019 with length of stay in hospital≥30 d were included. Clinical and laboratory variables for DVT at baseline were collected, and the diagnosis of DVT was confirmed by ultrasonography. Risk factors were developed by Multivariate logistic regression analysis. A total of 101 patients were included in the study, of which 77.2%(78/101) were diagnosed ischemic stroke and 22.8%(23/101)were confirmed hemorrhagic stroke. The overall incidence of DVT after acute stroke within 30 days was 19.8%(20/101). The level of D-dimer when DVT detected was significant increased than that on admission. Pulmonary infection and increased muscle tone as independent relevant factors for DVT were confirmed. Conclusions: Pulmonary infection as a risk factor and increased muscle tone as a protector factor for DVT were identified in patients after stroke and the significant change in level of D-dimer could be a warning for DVT occurrence. It helps with taking early managements to reduce the incidence of DVT in patients after stroke.

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Section: Analysis Of the Changes In Laboratory Variables When Dvt Detsupporting

confidence: 59%

Association of Clinical and Laboratory Variables with In-Hospital Incidence of Deep Vein Thrombosis in Patients with Acute Stroke: A Retrospective Study

Huang

Song

Peng

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Similarly, we found that microbiologically verified skin, bone and joint infections were high-risk infections for VTE, particularly if caused by S. aureus. That S. aureus skin and osteoarticular infection may be associated with a high risk for VTE has previously been suggested in case reports and smaller case series [15]–[17].…”

Section: Discussionmentioning

confidence: 74%

“…During systemic inflammatory activity, endothelial cell apoptosis, tissue-factor expression, thrombin generation and fibrin deposition is increased, while anticoagulatory pathways and fibrinolysis are impaired [20], [21]. Gram-positive bacteria, including S. aureus , may have an exceptionally high propensity for inducing thrombosis [17], [22]. Immobilization is a risk factor for VTE [12] and is pronounced during severe infection, especially infection causing bone and joint pain [23].…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism after Community-Acquired Bacteraemia: A 20-year Danish Cohort Study

et al. 2014

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BackgroundInfections may increase the risk for venous thromboembolism (VTE), but little is known about VTE risk associated with community-acquired bacteraemia (CAB). We examined the risk for VTE within one year of CAB in comparison to that in matched controls.MethodsWe conducted a population-based cohort study in North Denmark 1992–2011, using data from high-quality health-care databases. We included 4,213 adult CAB patients who had positive blood cultures drawn on the day of hospital admission, 20,084 matched hospitalised controls admitted for other acute medical illness, and 41,121 matched controls from the general population. We computed 0–90 and 91–365 day absolute risks for hospital-diagnosed VTE and used regression analyses with adjustment for confounding factors to compare the risk for VTE in bacteraemia patients and controls.ResultsAmong CAB patients, 1.1% experienced VTE within 90 days of admission and 0.5% during 91–365 days after admission. The adjusted 90-day odds ratio (OR) for VTE was 1.9 (95% CI 1.4–2.7) compared with hospitalised controls, and 23.4 (95% CI 12.9–42.6) compared with population controls. During 91–365 days after CAB admission, the VTE risk remained moderately increased (adjusted hazard ratio vs. hospitalised controls, 1.4; 95% CI 0.8–2.5, and vs. population controls, 1.9; 95% CI 1.0–3.3). Compared to hospitalised controls, the 90-day VTE risk increase was greater for Gram-positive infection (adjusted OR 2.5; 95% CI 1.6–4.1) than for Gram-negative infection (adjusted OR, 1.2; 95% CI 0.7–2.1), partly due to a high risk after Staphylococcus aureus infection (3.6%).ConclusionThe risk for VTE is substantially increased within 90 days after community-acquired bacteraemia when compared to hospitalised controls and population controls. However, the absolute risk of VTE following CAB is low.

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“…[33–34] Colonization by S. aureus , in addition to causing the majority of intravascular catheters-related infections [35] , can also induce platelet aggregation in vitro and induce the development of deep vein thrombosis in vivo . [36–37] …”

Section: Resultsmentioning

confidence: 99%

Thromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release

Ren

Colletta

Koley

et al. 2015

Bioelectrochemistry

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Inexpensive nitric oxide (NO) release strategies to prevent thrombosis and bacterial infections are desirable for implantable medical devices. Herein, we demonstrate the utility of electrochemically modulated NO release from a catheter model using an inner copper wire working electrode and an inorganic nitrite salt solution reservoir. These catheters generate NO surface fluxes of >1.0×10−10 mol min−1 cm−2 for more than 60 h. Catheters with an NO flux of 1.1×10−10 mol min−1 cm−2 are shown to significantly reduce surface thrombus formation when implanted in rabbit veins for 7 h. Further, the ability of these catheters to exhibit anti-biofilm properties against bacterial species commonly causing bloodstream and urinary catheter infections is examined. Catheters releasing NO continuously during the 2 d growth of S. aureus exhibit a 6 log-unit reduction in viable surface bacteria. We also demonstrate that catheters generating NO for only 3 h at a flux of 1.0×10−10 mol min−1 cm−2 lower the live bacterial counts of both 2 d and 4 d pre-formed E. coli biofilms by >99.9%. Overall, the new electrochemical NO-release devices could provide a cost-effective strategy to greatly enhance the biocompatibility and antimicrobial properties of intravascular and urinary catheters, as well as other implantable medical devices.

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The role of hypervirulent Staphylococcus aureus infections in the development of deep vein thrombosis

Cited by 22 publications

References 89 publications

Association of Clinical and Laboratory Variables with In-Hospital Incidence of Deep Vein Thrombosis in Patients with Acute Stroke: A Retrospective Study

Association of Clinical and Laboratory Variables with In-Hospital Incidence of Deep Vein Thrombosis in Patients with Acute Stroke: A Retrospective Study

Venous Thromboembolism after Community-Acquired Bacteraemia: A 20-year Danish Cohort Study

Thromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release

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