The role of hyperbaric oxygen in osteoradionecrosis—a prophylactic insight

Dang, Bich N.; Gamage, S.; Sethi, Sneha; Jensen, Emilija D.; Sambrook, Paul; Goss, AN

doi:10.1111/adj.12963

Cited by 2 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In irradiated tissues, HBO promotes angiogenesis, enhances neovascularization, fibroblast, and osteoblast proliferation, and increases collagen synthesis, and it has been proposed as both a preventive and therapeutic strategy for ORN [65,[88][89][90].…”

Section: Hbo Therapy and Orn Preventionmentioning

confidence: 99%

Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature

Corrao,

Mazzola,

Lombardi

et al. 2023

Biomedicines

View full text Add to dashboard Cite

Osteoradionecrosis (ORN) is a serious long-term complication of head and neck radiotherapy (RT), which is often triggered by dental extractions. It results from avascular aseptic necrosis due to irradiated bone damage. ORN is challenging to treat and can lead to severe complications. Furthermore, ORN causes pain and distress, significantly reducing the patient’s quality of life. There is currently no established preventive strategy. This narrative review aims to provide an update for the clinicians on the risk of ORN associated with oral surgery in head and neck RT patients, with a focus on the timing suitable for the oral surgery and possible ORN preventive treatments. An electronic search of articles was performed by consulting the PubMed database. Intervention and observational studies were included. A multidisciplinary approach to the patient is highly recommended to mitigate the risk of RT complications. A dental visit before commencing RT is highly advised to minimize the need for future dental extractions after irradiation, and thus the risk of ORN. Post-RT preventive strategies, in case of dento-alveolar surgery, have been proposed and include antibiotics, hyperbaric oxygen (HBO), and the combined use of pentoxifylline and tocopherol (“PENTO protocol”), but currently there is a lack of established standards of care. Some limitations in the use of HBO involve the low availability of HBO facilities, its high costs, and specific clinical contraindications; the PENTO protocol, on the other hand, although promising, lacks clinical trials to support its efficacy. Due to the enduring risk of ORN, removable prostheses are preferable to dental implants in these patients, as there is no consensus on the appropriate timing for their safe placement. Overall, established standards of care and high-quality evidence are lacking concerning both preventive strategies for ORN as well as the timing of the dental surgery. There is an urgent need to improve research for more efficacious clinical decision making.

show abstract

Section: Hbo Therapy and Orn Preventionmentioning

confidence: 99%

Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature

Corrao,

Mazzola,

Lombardi

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Alveolar osteonecrosis and tooth exfoliation following herpes zoster infection: A case report and review of the literature

Sun,

Chen,

et al. 2024

Australian Dental Journal

View full text Add to dashboard Cite

Tooth loss and osteonecrosis of the jaw are a serious and rare oral complications of herpes zoster infection, particularly in immunocompetent individuals. An immunocompetent 58‐year‐old male patient presented with a sudden exfoliation of almost all the teeth in his right mandible 2 days prior. Three weeks before this event, he had been diagnosed with herpes zoster infection, which led to irreversible necrosis on the right side of his mandible over 3 months. He was subsequently diagnosed with the osteonecrosis of the right mandible following herpes zoster infection and received aggressive treatment including medication, laser therapy and surgery. We present here our insights into the risk factors, differential diagnosis, pathogenesis and treatment options for this rare complication based on our case and latest literature review.

show abstract

The role of hyperbaric oxygen in osteoradionecrosis—a prophylactic insight

Cited by 2 publications

References 29 publications

Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature

Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature

Alveolar osteonecrosis and tooth exfoliation following herpes zoster infection: A case report and review of the literature

Contact Info

Product

Resources

About