The role of hydrogen sulfide in gastrointestinal tract functioning (review)

Волощук, Н. І.; Таран, И. В.; Pashynska, О. S.; Melnyk, A.V.; Magdebura, Savva

doi:10.2478/cipms-2020-0009

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Освітній процес здійснюється так, щоб знання однієї дисципліни були фундаментом для вивчення іншої. Таке методичне опрацювання навчального матеріалу полягає в систематизації і узагальненні його студентами [6].…”

Section: полтавський державний медичний університет полтава українаunclassified

Interdisciplinary Integration as a Main Factor іn the Development of Clinical and Professional Thinking of Students of Medical Higher Education Institutions of Ukraine

Shepitko¹,

Sherstyuk²,

Boruta³

et al. 2023

Ukr. ž. med. bìol. sportu

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The purpose of the study was to reveal the essence of an integrated approach to teaching fundamental disciplines as a key factor in the professional training of medical students. Materials and methods. Analysis, generalization and systematization of scientific and methodological literature were used in the study. Results and discussion. Integration significantly changes the content and structure of modern scientific knowledge, intellectual and conceptual capabilities of certain sciences. It is the most important means of achieving the unity of knowledge in the content, structural, scientific, organizational, and pedagogical aspects. Integration in the fundamental fields arose on the background of differentiation of sciences and detailing of specialties, the growing amount of knowledge and requirements for it in each individual field. Integration between academic disciplines is aimed at deepening the interconnections between subjects and is a way to improve it. The interdisciplinary integration of basic disciplines in higher medical institutions provides for a unified approach of the teaching staff of different disciplines to solving common educational problems based on the generalization of knowledge by students. Histology, cytology, embryology and human anatomy as disciplines that study the structure and morphological variations of the human body are perceived from the viewpoint of modern science as the basis of medicine, physiology and pathology, which has been gradually formed since ancient times and up to the current day. Such a close relation between the micro- and macro-structure of the body is consistent and logical in the study of two fundamental disciplines, it becomes possible to transfer theoretical knowledge, practical skills and abilities from one discipline to another. Creating interdisciplinary connections contributes to deeper learning and repetition of previously studied material, and properly organized integration plays both an educational and an upbringing role. The interdisciplinary integration of two fundamental disciplines such as Histology, Cytology and Embryology with Human Anatomy is a necessary component of the training of a future doctor. The use of such interdisciplinary technologies for training a doctor allows to raise him/her to a qualitatively new level of clinical thinking, capable of solving the problems of medical practice in a comprehensive manner based on the wide integration of information from various disciplines. Conclusion. Interdisciplinary integration helps to increase the professional motivation of students in the first and second years of studies in higher medical education, deepens their knowledge in specialized disciplines, activates the cognitive activity of students, promotes the formation of their competencies and improves the quality of knowledge, skills and abilities

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Section: полтавський державний медичний університет полтава українаunclassified

Interdisciplinary Integration as a Main Factor іn the Development of Clinical and Professional Thinking of Students of Medical Higher Education Institutions of Ukraine

Shepitko¹,

Sherstyuk²,

Boruta³

et al. 2023

Ukr. ž. med. bìol. sportu

View full text Add to dashboard Cite

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“…The literature describes a number of biologically active substances of endothelial and plasma origin, which regulate vascular tone. Among these mediators, in addition to prostaglandins, oxygen free radicals, nitric oxide, and H 2 S have recently been identified [4,13,24,25,28]. Therefore, the search for and research of new drugs that have anti-inflammatory and analgesic activity, it is necessary to establish their safety in the gastrointestinal tract.…”

Section: Table 1 Indicators Of Gastrotoxicity Of the Compound Ni-9 And Meloxicam Under Conditions Of Long-term Administration In Rats (M±mentioning

confidence: 99%

Investigation of 4-methyl-2.2-dioxo-1h-2λ6,1-benzothiazine-3-carboxamide derivative influence on the biochemical markers of gastric mucosa in rats

Malchenko

Волощук

Пентюк

2020

Biomed. and Biosoc. Anthrop.

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Non-steroidal anti-inflammatory drugs occupy a leading position in the pharmaceutical market, but their class-specific side effect (ulcerogenic action) significantly limits their widespread use. The N-(4-methoxybenzyl)-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide derivative (compound NI-9) showed a pronounced analgesic effect in various models of pain syndromes. The aim of the study was to determine the effect of a new original derivative of 4-methyl-2.2-dixo-1H-2λ6,1-benzothiazine-3-carboxylic acid on the macroscopic state and biochemical parameters of the gastric mucosa of rats. The study was performed on 51 male Wistar rats. Compound NI-9 and the reference drug meloxicam were administered intragastrically once daily for 28 days at doses of 3 and 5 mg/kg, corresponding to their ED50 analgesic activity. Macroscopic indicators of GM damage, glycosaminoglycan content, phospholipid profile, level of MDA and CGP, as well as nitrates and nitrites and H2S were determined. The results were processed in the program STATISTICA 10.0 using non-parametric methods. The results showed that the carboxamide derivative was safer for the stomach because the ulcer index of compound NI-9 was 1.73 times lower than that of meloxicam. The damaging effect of the compound was more pronounced at the pre-epithelial and epithelial levels of GM protection, while the post-epithelial level (production of vasodilating molecules NO and H2S) was practically unaffected by this derivative, unlike meloxicam, which caused damage at all levels of protection. The obtained data supplement the data on the pharmacodynamics of the 4-methyl-2.2-dixo-1H-2λ6,1-benzothiazine-3-carboxylic acid derivative and determine the expediency of its further studies as a potential non-opioid analgesic.

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“…Since then, there has been a dramatic shift from the belief that H 2 S works entirely as an environmental toxin to the understanding that H 2 S plays an important role in organ function and homeostasis [ 5 ]. H 2 S has been revealed to take part in the regulation of various pathophysiological conditions within mammalian systems, such as vascular tone and blood pressure [ 6 , 7 ], neurotransmission [ 8 ], angiogenesis [ 9 ], cardiac function [ 10 ], various leukocytic functions [ 11 ], penile erectile function [ 12 ], and gastrointestinal tract function [ 13 ]. In general, when the concentration of H 2 S in tissues or cells is high, H 2 S is regarded as a toxic substance and its oxidation products—persulfide, sulfite, thiosulfate, and sulfate—may give rise to cytotoxic effects through inhibiting mitochondrial cytochrome C oxidase and disrupting cell energy production, resulting in tissue inflammation or DNA damage [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells

Quan

Lee

2021

BioMed Research International

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Hydrogen sulfide (H2S) plays an important role in mammals as a signaling molecule. Recently, abnormal H2S concentration has been associated with several pathophysiological states, such as diabetes mellitus, hypertension, Alzheimer’s disease, and Parkinson’s disease. As regulating H2S concentration can be a very prominent way of developing new drugs, many researchers have paid great attention to H2S research. To understand the role of H2S in pathophysiology and develop H2S-based therapies, it is necessary to measure the exact concentration of H2S within biological systems. But, H2S is volatile and can be easily oxidized. Besides, the active sites for several biological effects of H2S are inside the cell. Therefore, there is a need for the development of new methods for the accurate and reliable detection of H2S within live cells. This review provides a summary of recent developments in H2S detection methods for live cell analysis.

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The role of hydrogen sulfide in gastrointestinal tract functioning (review)

Cited by 4 publications

References 48 publications

Interdisciplinary Integration as a Main Factor іn the Development of Clinical and Professional Thinking of Students of Medical Higher Education Institutions of Ukraine

Interdisciplinary Integration as a Main Factor іn the Development of Clinical and Professional Thinking of Students of Medical Higher Education Institutions of Ukraine

Investigation of 4-methyl-2.2-dioxo-1h-2λ6,1-benzothiazine-3-carboxamide derivative influence on the biochemical markers of gastric mucosa in rats

Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells

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