The Role of Human Milk Secretory IgA in Protecting Infants from Bacterial Enteritis

Noguera-Obenza, Marita; Cleary, Thomas G.

doi:10.1007/978-1-4615-0661-4_10

Cited by 2 publications

(2 citation statements)

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“…Secretory Immunoglobulin A (sIgA) has been identified in breast milk as an antibody recognizing various bacterias and viruses, including E. coli, Shigella, Salmonella, Campylobacter pylori, Vibrio cholerae, Haemophilus influenzae, Streptococcus pneumoniae, Grup B Streptococcus tipe III, Staphylococcus aureus, Clostridium difficile, Clostridium botulinum, Klebsiella pneumonia, Listeria monocytogenes, enterovirus, human immunodeficiency virus (HIV), Respiratory Syncytial Virus (RSV), Rubella, Norovirus, and porcine corona virus. 3 sIgA in breast milk are mainly produced by plasma cells in mammae gland and modified in entire mammary gland epithelium translocation. Nearly 75% of Ig A processed in GI tract are remained and secreted along with feces.…”

Section: Introductionmentioning

confidence: 99%

Oral Care Colostrum Effect on Preterm Infants Fecal Immunoglobulin A Secretory Level

2020

IJFMT

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Objective To evaluate whether oral care colostrum can increase fecal secretory immunoglobulin A levels in preterm infants.Methods Thirty-eight infants who met the inclusion criteria were randomized. Twenty colostrum oral care infants and eighteen control control infants. Colostrum oral care by giving as much as 0.1 ml of colostrum on each buccal mucosa for approximately 2 minutes on one side. The procedure is repeated every 4 hours for 3 days. Fecal secretory immunoglobulin A levels are taken from the first faecal after birth and 72 hours after colostrum administration. Fecal retrieval must first install a urine device so that the urine does not wet the sample.Result Fecal secretory immunoglobulin A level before treatment in the treatment group were 0.0633 ± 0.0037 mg/g feces higher than the control group 0.0166 ± 0.0139 mg/g feces, statistically there were no significant differences (p = 0.595). Fecal secretory immunoglobulin A level after treatment in the treatment group amounted to 1,1007 ± 0.2458 mg/g feces higher than the control group 0.6045 ± 0.2358 mg/g faeces, statistically there were no significant differences (p = 0.09 ). Difference in increase in secretory fecal immunoglobulin A levels after and before treatment in the treatment group 1.0374 ± 0.2575 mg/g feces is higher than the control group 0.5879 ± 0.2385 mg/g feces, statistically there were no significant differences (p = 0.09). ConclusionOral care colostrum has been shown to increase secretory immunoglobulin A levels in preterm infants before colostrum oral care, and colostrum oral care has the potential to increase faecal secretory immunoglobulin A level than controls in preterm infants.

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Section: Introductionmentioning

confidence: 99%

Oral Care Colostrum Effect on Preterm Infants Fecal Immunoglobulin A Secretory Level

2020

IJFMT

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“…In human milk the most prevalent Ig is IgA, which is secreted as a dimer complexed with secretory component ( Brandtzaeg, 2013 ; Cakebread, Humphrey & Hodgkinson, 2015 ). Secretory IgA in human milk protects the infant against enteric infection ( Noguera-Obenza & Cleary, 2001 ) and is thought to act within the intestinal lumen to maintain microbial homeostasis ( Mestecky, 2001 ; Noguera-Obenza & Cleary, 2001 ). Cows’ milk differs in composition from human milk, containing relatively low concentrations of IgA and higher concentrations of IgG which is important for passive immunisation of the new born calf ( Korhonen, Marnila & Gill, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Bovine milk derived skimmed milk powder and whey protein concentrate modulatesCitrobacter rodentiumshedding in the mouse intestinal tract

Cakebread

Hodgkinson

Wallace

et al. 2018

PeerJ

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Skimmed milk powder (SMP) and whey protein concentrate (WPC) were manufactured from fresh milk collected from cows producing high or low Immunoglobulin (Ig) A levels in their milk. In addition commercial products were purchased for use as diluent or control treatments. A murine enteric disease model (Citrobacter rodentium) was used to assess whether delivery of selected bioactive molecules (IgA, IgG, Lactoferrin (Lf)) or formulation delivery matrix (SMP, WPC) affected faecal shedding of bacteria in C. rodentium infected mice. In trial one, faecal pellets collected from mice fed SMP containing IgA (0.007–0.35 mg/mL), IgG (0.28–0.58 mg/mL) and Lf (0.03–0.1 mg/mL) contained fewer C. rodentium (cfu) compared to control mice fed water (day 8, p < 0.04, analysis of variance (ANOVA) followed by Fisher’s unprotected least significant difference (ULSD)). In trial two, WPC containing IgA (0.35–1.66 mg/mL), IgG (0.58–2.36 mg/mL) and Lf (0.02–0.45 mg/mL) did not affect C. rodentium shedding, but SMP again reduced faecal C. rodentium levels (day 12, p < 0.04, ANOVA followed by Fisher’s ULSD). No C. rodentium was detected in sham phosphate-buffered saline inoculated mice. Mice fed a commercial WPC shed significantly greater numbers of C. rodentium over 4 consecutive days (Fishers ULSD test), compared to control mice fed water. These data indicate that SMP, but not WPC, modulates faecal shedding in C. rodentium-infected mice and may impact progression of C. rodentium infection independently of selected bioactive concentration. This suggests that food matrix can impact biological effects of foods.

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The Role of Human Milk Secretory IgA in Protecting Infants from Bacterial Enteritis

Cited by 2 publications

References 48 publications

Oral Care Colostrum Effect on Preterm Infants Fecal Immunoglobulin A Secretory Level

Oral Care Colostrum Effect on Preterm Infants Fecal Immunoglobulin A Secretory Level

Bovine milk derived skimmed milk powder and whey protein concentrate modulatesCitrobacter rodentiumshedding in the mouse intestinal tract

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