The role of HLA-antigens in Prurigo Hebra

Boediardja, Siti Aisah; Moeslichan, S; Cornain, Santoso; Budimulja, Unandar; Djuanda, Adhi

doi:10.13181/mji.v9i4.616

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(2 citation statements)

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“…Other types such as HLA-A 6602(10), HLA-B27, and HLA-B63 (15) were associated with the severity, while HLA-B35 was found as a significant protective factor (RR=0.17 with 95% C.I.=0.04;0.65). 21 This indicated that there were multiple genes (polygenes) involved. The contribution of HLA genes supported the characteristics of multi-factorial inheritance pattern.…”

Section: Discussionmentioning

confidence: 99%

“…10 In this study female was predominant, RR = 2 (95% CI: 0.127;0.922), meaning that female had the risk twice higher than male to suffer from prurigo Hebra. 21 Naturally in AD and AR pattern, both sexes have the same possibility to be affected. This study showed sex liability; among probands female/male ratio was 39:11, while among affected members 99:33.…”

Section: Discussionmentioning

confidence: 99%

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Genetic inheritance pattern in prurigo Hebra

Boediardja

Ramelan

Cornain

2001

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A study was conducted to analyze the multifactorial genetic inheritance pattern in prurigo Hebra (PH). Fiftyprobands (PH patients) consisting of 11 males and 39 females, with age ranged from 5-30 years were included in this study.A three-generation family tree was obtained from each subject, from which a total of 79 families were eligible for analysis. Foreach family the possible mode of inheritance, namely autosomal dominant (AD) or autosomal recessive (AR), was predicted.The families were then grouped according to the mode of inheritance. Analysis was conducted using Chi-square test,comparing the observed occurrence of PH and the expected value for each mode. To rule out mutation, the second methodwas applied, which only families with more than one affected child were analyzed, was used. The genetic inheritancepattern was not consistently compatible either with AR or AD. This finding, and other supporting facts, such as femalepreponderace, the role of HLA and the lower morbidity rate compared to the expected rate in AR or AD mode, indicated thatthe genetic inheritance of PH follows a multi-factorial pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%