Genetic inheritance pattern in prurigo Hebra

Abstract

A study was conducted to analyze the multifactorial genetic inheritance pattern in prurigo Hebra (PH). Fiftyprobands (PH patients) consisting of 11 males and 39 females, with age ranged from 5-30 years were included in this study.A three-generation family tree was obtained from each subject, from which a total of 79 families were eligible for analysis. Foreach family the possible mode of inheritance, namely autosomal dominant (AD) or autosomal recessive (AR), was predicted.The families were then grouped according to the mode of inheritance. Analysis was conducted using Chi-square test,comparing the observed occurrence of PH and the expected value for each mode. To rule out mutation, the second methodwas applied, which only families with more than one affected child were analyzed, was used. The genetic inheritancepattern was not consistently compatible either with AR or AD. This finding, and other supporting facts, such as femalepreponderace, the role of HLA and the lower morbidity rate compared to the expected rate in AR or AD mode, indicated thatthe genetic inheritance of PH follows a multi-factorial pattern.

Dermatose Comum No Passado, Mas Que Ainda Desafia Os Dermatologistas - Qual O Seu Diagnóstico?

“…Skin hyperreactivity has intrinsic (genetic) and extrinsic multifactorial basis and is closely associated with inadequate hygiene and poor nutrition. 6 A perivascular infiltrate in the central region of the wheal consisting of lymphocytes and eosinophils is observed both in new and old lesions but differences between new and old lesions are noted in histopathology. Recent lesions show hypergranulosis and normal stratum corneum, vasodilation with oedema and vascular endothelial cells protrusion in the lumen as well as increased numbers of eosinophils in the infiltrate, while the old lesions show with thickened collagen and decreased fibrocytes in the dermis.…”

“…It is believed to have a multifactorial predisposition. 6 Hebra's prurigo is considered a chronic and recurrent inflammatory skin disease, with cutaneous hyperreactivity to environmental stimuli (insect bites) possibly enhanced by skin barrier dysfunction and is often associated with atopy. Skin hyperreactivity has intrinsic (genetic) and extrinsic multifactorial basis and is closely associated with inadequate hygiene and poor nutrition.…”