The role of H. pylori infection in gall bladder cancer: clinicopathological study

Hassan, Elham A.; Gerges, Shawkat S.; El-Atrebi, Kamal A; El-Bassyouni, Hala T.

doi:10.1007/s13277-015-3444-9

Cited by 23 publications

(19 citation statements)

References 22 publications

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“…In this study, the group with both gallstones and polypoid lesions presented with significantly higher rates of HP infection, which implies that HP infection is related to stone occurrence rather than polypoid lesions. However, more studies are needed to establish the potential relationship between HP infection and malignant transformation of GB polypoid lesions, which may be caused by aggravation of the GB mucosal lesions (hyperplasia, metaplasia, or lymphoid infiltration)26 or by the development of gallstones.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

et al. 2016

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PurposeTo determine the prevalence of and investigate the risk factors for gallbladder (GB) polypoid lesions in a healthy population.Materials and MethodsA total of 23827 subjects who underwent abdominal ultrasonography in conjunction with health screening examinations were retrospectively analyzed. The prevalence of risk factors for GB polypoid lesions were evaluated. In addition, risk factors according to the number of polypoid lesions and the presence of stones with polypoid lesions were investigated. To analyze these risk factors, a control group was established with a 1:2 ratio matched for age and sex.ResultsThe prevalence of GB polypoid lesions was identified as 9.96%. On multivariate analysis, chronic hepatitis B infection (CHB) and the presence of metabolic syndrome (MS) were risk factors for GB polypoid lesions. CHB and MS were also significant independent risk factors for multiple GB polypoid lesions when compared with solitary GB polypoid lesions. In addition, gastric Helicobacter pylori infection and MS were significant risk factors for GB polypoid lesions with stones when compared with GB polypoid lesions without stones.ConclusionThe prevalence of GB polypoid lesions in a healthy Korean population was 9.96%. Patients with CHB and MS need to be carefully examined for such lesions.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

et al. 2016

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“…While it is possible that the presence of a tumor may stimulate bacterial growth, the results of the current study could not have been due to an effect of infections on gallstone development since we compared GBC cases to patients with gallstones. In addition, lymphoid infiltrate and precancerous histologic findings in the gallbladder, including mucosal hyperplasia, metaplasia and dysplasia have been more frequently observed in patients with Helicobacter pylori infection arguing for a role of bacterial involvement in GBC development [35]. When considered in the context of these findings, the relationship between the responses to Gram-negative bacteria and GBC warrants further exploration.…”

Section: Discussionmentioning

confidence: 99%

Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation

Dyke

Kemp

Corbel

et al. 2016

Annals of Epidemiology

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Purpose We examined inflammation as a mediator of associations between bacterial infection markers and gallbladder cancer (GBC). Methods Bacterial response proteins [lipopolysaccharide (LPS), soluble CD14 (sCD14), and LPS-binding protein (LBP)] were measured in 40 GBC cases and 126 gallstone controls with data on 63 serum inflammation markers. The relationships of LPS, LBP, and sCD14 with GBC were examined by logistic regression, which also was used to evaluate whether these associations are influenced by systemic inflammation as measured by a combinatorial inflammation score. Results The third versus the first tertiles of sCD14 and of LBP were associated with an increased GBC risk [Odds Ratio (95% Confidence Interval): 5.41 (2.00–16.75) for sCD14, and 6.49 (2.24–23.79) for LBP]. sCD14 and LBP were strongly associated with inflammation score (above versus below the median), which itself was associated with a >21-fold increased risk of GBC for the third vs. first tertiles. Associations between GBC and sCD14 and LBP were markedly attenuated when the inflammation score was included in the model. While LPS was not associated with GBC or inflammation, only 35% of cases and 22% of controls had detectable levels. Conclusions These findings suggest that these LPS-pathway proteins are associated with GBC via inflammation-related pathways.

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“…Therefore, in their study there was a statistically significant difference between the two groups (P=0.049) regarding mucosal metaplasia. 16 Regarding association of H. pylori infection with gall stones, it was more common in H. pylori negative cases (82%) as compared to H pylori positive cases (76%). The results were similar to that of another study in which the prevalence of gallstones in H pylori positive cases was lower than in the H pylori-negative cases (odds ratio, 0.653) 11 In our study, fibrosis was present in most of the H pylori positive cases (94%) whereas it was less (79%) in non-infected patients proving its association with chronic cholecystitis.…”

Section: Discussionmentioning

confidence: 95%

“…This gram-negative rod has previously been associated with gastritis and acid peptic disease 8 for decades and studies have been carried out to show its association with gallstones, cholecystitis 13,14 and gall bladder cancer. 15 Many serological and histological methods 16,17 have been used to detect its presence in gall bladder mucosa and bile including Giemsa staining, H&E, PCR, Urease test, Warthin-starry 18 test etc. Out of these Giemsa and H&E are considered the simplest, cheapest and most specific methods.…”

Section: Original Articlementioning

confidence: 99%

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Jimdc¹,

Mushtaq²

2019

JIMDC

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Background: Since H pylori has been mostly associated with gastritis its presence in other parts of gastrointestinal system has not been studied much. Few previous studies have identified “H pylori” in gallbladder and found its association in causing cholecystitis and gallstones but only a few studies have been performed in Pakistan that have shown a significant association. Therefore, in this study we looked for the presence of this microorganism in cholecystitis patients and its association with the morphological changes seen in gall bladders. Material and method: All patients with acute and chronic cholecystitis admitted in ANTH between the ages of 18 and 75 years from January 2017 till March 2019, who underwent cholecystectomy, were included in the study. Gall bladder specimens after surgery were sent to Pathology department ANTH and specimens were analyzed for the presence of H pylori bacteria using H&E and Giemsa staining. Signs of inflammation, any hyperplasia, metaplasia, mucosal atrophy or erosion, lymphoid infiltration, fibrosis, cholesterolosis or any other morphological changes were also noted. Association of H.pylori with cholecystitis and other morphological changes were checked by Chi Square analysis. P. value less than 0.05 was considered statistically significant Results: Chronic cholecystitis was present in 91% cases and acute cholecystitis in 9%. Other histological findings were Hyperplasia (10%), Metaplasia (15%), Fibrosis (79%), Cholesterolosis (19%) and ulcerations (36%). H pylori was found in 17% of gall bladders and all the cases were of chronic cholecystitis. Among these, there were 11.7% Males and 88% Females. Gallstones were present in 76.4% cases and age group involvement was seen more among 41-60 years (64.7%). Other histological findings seen in hpylori positive cases were; Hyperplasia in 11.7% cases, Metaplasia in 17.6%, Fibrosis in 94.1%, cholesterolosis in 23.5% and ulcerations in 17.6% cases. Association of H-Pylori with gender, cholecystitis, gall stones, histological features and age distribution was non-significant. Conclusion: Although H pylori infection has been found in cases of chronic cholecystitis and gall stone formation, its association with cholecystitis and other morphological changes could not be proved. Hence, it is uncertain whether H pylori eradication in patients with gastritis can prevent cholecystitis or gall stones formation

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The role of H. pylori infection in gall bladder cancer: clinicopathological study

Cited by 23 publications

References 22 publications

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

Lipopolysaccharide-pathway proteins are associated with gallbladder cancer among adults in Shanghai, China with mediation by systemic inflammation

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

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