The Role of H in the Development of A

Abstract

A(2) cord bloods do not react with Dolichos bif. anti-A and their H status is equivalent to that of group O cord bloods, indicating that the A components of these bloods are formed independently of H. Bloods reacting with Dolichos bif. extract require H for the development of their A(1) components and this is reflected in the lower H status of these bloods. As the alternative pathway is necessary for the development of the first formed parts of A both the alternative and the orthodox pathways are necessary for the development of bloods with A(1) components.

The Incidence of H Deficient A(2) and A(2)B Bloods and Family Studies on the AH/ABH Status of an A(int) and Some New Variant Blood Types

“…The studies presented in this paper reveal the frequency of AH/ ABH variants in the Sheffield area and the family studies on the examples of the various types of variant provide yet a further dem onstration of the vital role of H in the development of the A antigen of red cells showing At characteristics [11,12].…”

“…family contained an example of an H deficient A2B blood that had a weakened A2 status (A2|Bhw) which rather suggested that the A2 gene action requires H for the formation of A red cell antigens. However, the theory that some parts of A utilise little or no H for their formation [12] is still not disproved as normal A2B bloods have an A2 status only about half that of an A2 blood, and yet they are not H deficient ( fig. 9).…”

Observations on the Thermal Optimum, Saline Agglutinating Activity and Partial Neutralization Characteristics of IgG Anti-A Antibodies

“…The cord cells were classified as Ax and A2, as pre viously described [17]. All cells were washed 4 times before use.…”

A Study of the Antibodies of the H'O'I-B Complex with Special Reference to Their Occurrence and Notation

“…Our studies show that most of the non-inhibit able antibodies formerly [30] or A2hAl [34] bloods demonstrates the importance of the relationship of H [3,21,30,35,40] to the A and B blood group substances. As the metabolic block preventing the formation of H also prevents the formation of the substance that reacts with these so-called anti-'0' sera then, this substance also is a part of the H mosaic.…”