The Incidence of H Deficient A(2) and A(2)B Bloods and Family Studies on the AH/ABH Status of an A(int) and Some New Variant Blood Types

ABO, H, and Lewis Systems

“…In a study of 5000 African Americans, 80% of group A individuals were A 1 and 20% A 2 , whereas 53% of the group AB individuals were A 1 B and 47% were A 2 B [362] . Similar discrepancies have been observed in white people [233,344] , Chinese [332] , and Japanese [213,363] . This imbalance in Japanese is due, at least in part, to an ABO allele ( A204 : Arg176Gly, Gly235Ser, Val277Met) that is expressed as A 1 in A 1 /O genotype, but as A 2 in A 2 /B genotype [213] .…”

Serology and Genetics of the A(1) High H Subgroup

“…A variety of H alleles has been postulated by us earlier [2] and later supported by Voak et al [12], Thus, the complex genetic pattern involving interaction of a variety of H alleles, acted upon by a series of similar A and B alleles could explain the large variety of different variants of the ABH(O) system as encountered all over the world. Most notable among these variants are Oh, Ah, A,!…”

Action of African B Gene on A(1), Subgroup of A

“…Voak and Lodge [2] gave a possible explanation for the excess of A2B phenotypes observed in some populations and again in another extensive family study, Voak et al [4] reported on H-deficient A2B bloods. Using similar methods of studying H-content, Ssebabi [1] found an increased incidence of A2B phenotypes in Ugandan Africans with A2 BHw 45.9%, A2BHw 36.6% and the normal A2B 5.2% of all AB samples.…”

“…A-and H-content studies were carried out on 18 relatives. The methods and reagents used to estimate A and H where the same as those used by Ssebabi [1] and Voak et al [3,4],…”