The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury

Caillard, P.; Bennis, Youssef; Six, Isabelle; Bodeau, Sandra; Kamel, Saı̈d; Choukroun, Gabriel; Maizel, Julien; Titeca-Beauport, Dimitri

doi:10.3390/toxins14050336

Cited by 5 publications

(1 citation statement)

References 113 publications

(143 reference statements)

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“…Normally, circulatory uremic toxins are excreted from the kidney through organic anion transporters (OATs), but kidney dysfunction leads to their accumulation in the kidney. Accumulated uremic toxins are responsible for endothelial dysfunction, ROS production, pro-inflammatory factor expression, and leukocyte extravasation, eventually exacerbating kidney damage [150].…”

Section: Mechanism 631 Intestinal Microbiota and Its Productsmentioning

confidence: 99%

Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Yuan

Zhou

2022

JCM

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Acute kidney injury (AKI) is becoming a public health problem worldwide. AKI is usually considered a complication of lung, heart, liver, gut, and brain disease, but recent findings have supported that injured kidney can also cause dysfunction of other organs, suggesting organ crosstalk existence in AKI. However, the organ crosstalk in AKI and the underlying mechanisms have not been broadly reviewed or fully investigated. In this review, we summarize recent clinical and laboratory findings of organ crosstalk in AKI and highlight the related molecular mechanisms. Moreover, their crosstalk involves inflammatory and immune responses, hemodynamic change, fluid homeostasis, hormone secretion, nerve reflex regulation, uremic toxin, and oxidative stress. Our review provides important clues for the intervention for AKI and investigates important therapeutic potential from a new perspective.

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Section: Mechanism 631 Intestinal Microbiota and Its Productsmentioning

confidence: 99%

Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Yuan

Zhou

2022

JCM

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Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats

Nayak,

Boopathi,

Chandrasekar

et al. 2024

Toxicology and Applied Pharmacology

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Kidney disease and stroke: epidemiology and potential mechanisms of susceptibility

Bobot

Suissa

Hak

et al. 2023

Nephrology Dialysis Transplantation

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Patients with Chronic Kidney Disease (CKD) have an increased risk of both ischemic and haemorrhagic stroke compared to the general population. Both acute and chronic kidney impairment are independently associated with poor outcome after the onset of a stroke, after adjustment on confounders. End-stage kidney disease (ESKD) is associated with a 7- and 9-fold increased incidence of both ischemic and haemorrhagic strokes, respectively, poorer neurological outcome and a 3-fold higher mortality. Acute kidney injury (AKI) occurs in 12% of patients with stroke and is associated with a 4-fold increased mortality and unfavourable functional outcome. CKD patients seem to have less access to revascularisation techniques like thrombolysis and thrombectomy despite their worst prognosis. Even if CKD patients could benefit from these specific treatments in acute ischemic stroke, their prognostic remain poorer. After thrombolysis, CKD is associated with a 40% increased risk of intracerebral haemorrhage (ICH), a 20% increase in mortality and a poorer functional neurological outcome. After thrombectomy, CKD is not associated with ICH but still associated with an increased mortality, and AKI with unfavourable outcome and mortality. The beneficial impact of gliflozins on the prevention of stroke is still uncertain. Non-traditional risk factors of stroke, like uremic toxins, can lead to chronic cerebrovascular disease predisposing to stroke in CKD, notably through an increase in the blood-brain barrier permeability and impaired coagulation and thrombosis mechanisms. Preclinical and clinical studies are needed to specifically assess the impact of these non-traditional risk factors on the stroke incidence and outcomes, aiming to optimize and identify potential therapeutic targets.

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The Role of Gut-Derived, Protein-Bound Uremic Toxins in the Cardiovascular Complications of Acute Kidney Injury

Cited by 5 publications

References 113 publications

Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats

Kidney disease and stroke: epidemiology and potential mechanisms of susceptibility

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