Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Li, Xiaolong; Yuan, Feifei; Zhou, Lili

doi:10.3390/jcm11226637

Cited by 15 publications

(10 citation statements)

References 211 publications

(245 reference statements)

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“…These results may support the theory of crosstalk between the kidneys and nervous system, as seen in both in vitro and in vivo studies [ 16 , 17 ]. Sustained kidney injury and reduced renal function can have detrimental effects on the function and structure of the kidneys, brain, gut, lungs, heart, and immune system [ 18 , 19 ]. Given that the kidneys and brain are both end organs, they share similar anatomical and vascular systems and hemodynamic features, which make them vulnerable to vascular damage [ 16 , 18 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Link between Chronic Kidney Disease and Alzheimer’s Disease: A Longitudinal Follow-Up Study Using the Korean National Health Screening Cohort

et al. 2023

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Chronic kidney disease (CKD) and Alzheimer’s disease (AD) are common chronic diseases in the elderly population. Although a relationship between CKD and the occurrence of AD has been proposed, previous research results have been disputed, and further investigation is necessary to confirm this relationship. In this longitudinal follow-up study, we examined data from the Korean National Health Insurance Service-Health Screening Cohort, consisting of 15,756 individuals with CKD and 63,024 matched controls aged ≥40 years who received health check-ups between 2002 and 2019. Overlap-weighted Cox proportional hazard regression models were exploited to calculate hazard ratios (HRs) for the association between CKD and AD. During the monitoring period, individuals with CKD had a greater incidence of AD than those without CKD (15.80 versus 12.40 per 1000 person years). After accounting for various factors, CKD was significantly associated with a 1.14-fold increased likelihood of developing AD, with a 95% confidence interval ranging from 1.08 to 1.20. In subgroup analysis, this relationship persisted irrespective of age (≥70 or <70), sex, income, smoking status, alcohol consumption, place of residence, or fasting blood glucose level. Additionally, the association between CKD and AD was still evident among patients who were overweight or obese, those with normal blood pressure or cholesterol levels, and those without any other health conditions or with a CCI score of ≥2. These results suggest that CKD could increase the probability of developing AD in the Korean adult population irrespective of demographic or lifestyle conditions. This may make it challenging to predict AD in patients with CKD, emphasizing the importance of frequent AD screening and management.

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Section: Introductionmentioning

confidence: 99%

Exploring the Link between Chronic Kidney Disease and Alzheimer’s Disease: A Longitudinal Follow-Up Study Using the Korean National Health Screening Cohort

et al. 2023

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“…These findings may lend credence to the hypothesis of bidirectional interactions between the kidneys and the nervous system, as demonstrated in both in vitro and in vivo research [ 21 , 22 ]. It is known that persistent renal injury and diminished renal function can adversely impact the function and structure of various organ systems, including the brain, gut, lungs, heart, and immune system [ 23 , 24 ]. Therefore, it is plausible that CKD and PD may share common risk factors and underlying mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Link between Chronic Kidney Disease and Parkinson’s Disease: Insights from a Longitudinal Study Using a National Health Screening Cohort

Kwon

Kim

et al. 2023

Nutrients

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Chronic kidney disease (CKD) and Parkinson’s disease (PD) are common illnesses found in the geriatric population. A potential link between CKD and PD emergence has been hypothesized; however, existing conclusions are disputed. In this longitudinal research, we analyzed data acquired from the Korean National Health Insurance Service-Health Screening Cohort. The dataset comprised the health information of 16,559 individuals clinically diagnosed with CKD and 66,236 control subjects of comparable ages, all aged ≥40 years. These subjects participated in health examinations from 2002 to 2019. To assess the correlation between CKD and PD, we employed overlap-weighted Cox proportional hazard regression models. The unadjusted, crude hazard ratio for PD was greater in the CKD group than in the control group (crude hazard ration (HR) 1.20; 95% confidence interval (CI) = 1.04–1.39; p = 0.011). However, the Cox proportional hazard regression analysis, incorporating propensity score overlap weighting, revealed no significant discrepancy after considering confounding variables such as demographic factors, socio-economic status, lifestyle, and concurrent health conditions (adjusted HR (aHR), 1.09; 95% CI = 0.97–1.22; p = 0.147). Subgroup analyses showed a higher probability of PD development among certain CKD individuals, including those who resided in rural areas (aHR, 1.19; 95% CI = 1.03–1.37; p = 0.022), maintained a normal weight (aHR, 1.29; 95% CI = 1.08–1.56; p = 0.006), or had fasting blood glucose levels ≥100 mg/dL (aHR, 1.18; 95% CI = 1.00–1.39; p = 0.046). Therefore, these clinical or environmental factors may influence the incidence of PD in CKD patients. In conclusion, our results suggest that the general CKD population may not exhibit a greater propensity for PD than their non-CKD counterparts. However, this might be contingent upon specific lifestyle and comorbid conditions. Thus, certain lifestyle alterations could be crucial in mitigating the potential manifestation of PD in patients diagnosed with CKD.

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“…In a rat model of renal ischemiareperfusion, intestinal tight junction (TJ) integrity became disrupted 13 . The in ux of luminal toxins induces endotoxemia and further jeopardizes renal function, the so-called gut-kidney crosstalk 14 .…”

Section: Introductionmentioning

confidence: 99%

Prediction models combining zonulin, LPS, and LBP predict acute kidney injury and hepatorenal syndrome–acute kidney injury in cirrhotic patients

Lin

Kuo

Shen

et al. 2023

Preprint

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The development of acute kidney injury (AKI) and hepatorenal syndrome-acute kidney injury (HRS-AKI) in cirrhosis has been associated with intestinal barrier dysfunction and gut-kidney crosstalk. We use the related markers such as zonulin, lipopolysaccharides (LPS), and lipopolysaccharide-binding protein (LBP) to predict AKI and HRS-AKI in cirrhotic patients and evaluate their in vitro effects on intestinal (Caco-2) cells and renal tubular (HK-2) cells. From 2013 to 2020, we enrolled 70 cirrhotic patients and developed prediction models for AKI and HRS-AKI over a six-month period. There were 13 (18.6%) and 8 (11.4%) cirrhotic patients who developed AKI and HRS-AKI. The prediction models incorporated zonulin, LPS, LBP, C-reactive protein, age, and history of hepatitis B for AKI, and zonulin, LPS, LBP, total bilirubin, and Child-Pugh score for HRS-AKI. The area under curve (AUC) for the prediction of AKI and HRS-AKI was 0.94 and 0.95, respectively. Furthermore, the conditioned medium of LPS + hrLBP pre-treated Caco-2 cells induced apoptosis, necrosis, and zonulin release in HK-2 cells, demonstrating the communication between them. This study found that zonulin, LPS, and LBP are potential practical markers for predicting AKI and HRS-AKI in cirrhotic patients, which may serve as potential targets for renal outcomes in cirrhotic patients.

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Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Cited by 15 publications

References 211 publications

Exploring the Link between Chronic Kidney Disease and Alzheimer’s Disease: A Longitudinal Follow-Up Study Using the Korean National Health Screening Cohort

Exploring the Link between Chronic Kidney Disease and Alzheimer’s Disease: A Longitudinal Follow-Up Study Using the Korean National Health Screening Cohort

Exploring the Link between Chronic Kidney Disease and Parkinson’s Disease: Insights from a Longitudinal Study Using a National Health Screening Cohort

Prediction models combining zonulin, LPS, and LBP predict acute kidney injury and hepatorenal syndrome–acute kidney injury in cirrhotic patients

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