The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis

Comberiati, Pasquale; Cicco, Maria Di; Paravati, Francesco; Pelosi, U; Gangi, Alessandro Di; Arasi, Stefania; Barni, Simona; Caimmi, Davide; Mastrorilli, Carla; Licari, Amelia; Chiera, Fernanda

doi:10.3390/ijerph182212220

Cited by 20 publications

(27 citation statements)

References 126 publications

(171 reference statements)

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“…Pulmonary tuberculosis (PTB) is one of the most common infectious diseases and remains a major infectious cause of death worldwide ( Pezzella, 2019 ). Emerging scientific research hints at a possible role of the gut microbiota in the pathophysiology of tuberculosis (TB) ( Comberiati et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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IntroductionRecent studies have provided insights into the important contribution of gut microbiota in the development of Pulmonary Tuberculosis (PTB). As a chronic consumptive infectious disease, PTB involves many pathological characteristics. At present, research on intestinal flora and clinical pathological Index of PTB is still rare.MethodsWe performed a cross-sectional study in 63 healthy controls (HCs) and 69 patients with untreated active PTB to assess the differences in their microbiota in feces via 16S rRNA gene sequencing.ResultsSignificant alteration of microbial taxonomic and functional capacity was observed in PTB as compared to the HCs. The results showed that the alpha diversity indexes of the PTB patients were lower than the HCs (P<0.05). Beta diversity showed differences between the two groups (P<0.05). At the genus level, the relative abundance of Bacteroides, Parabacteroides and Veillonella increased, while Faecalibacterium, Bifidobacterium, Agathobacter and CAG-352 decreased significantly in the PTB group, when compared with the HCs. The six combined genera, including Lactobacillus, Faecalibacterium, Roseburia, Dorea, Monnoglobus and [Eubacterium]_ventriosum_group might be a set of diagnostic biomarkers for PTB (AUC=0.90). Besides, the predicted bacterial functional pathway had a significant difference between the two groups (P<0.05), which was mainly related to the nutrient metabolism pathway. Significant alterations in the biochemical index were associated with changes in the relative abundance of specific bacteria, the short chain fatty acid (SCFA)-producing bacteria enriched in HCs had a positively correlated with most of the biochemical indexes.DiscussionOur study indicated that the gut microbiota in PTB patients was significantly different from HCs as characterized by the composition and metabolic pathway, which related to the change of biochemical indexes in the PTB group. It was hypothesized that the abovementioned changes in the gut microbiota could exert an impact on the clinical characteristics of PTB through the regulation of the nutrient utilization pathway of the host by way of the gut-lung axis.

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Section: Introductionmentioning

confidence: 99%

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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“… Decrease in Faecalibacterium prausnitzii, Eubacterium ventriosum, Roseburia and Lachnospiraceae. [ 28 , [128] , [129] , [130] , [131] , [132] , [133] , [134] , [135] ] Lung Cancer Increase in Firmicutes and TM7 (Streptococcus, Veillonella, Megasphaera), Enterobacter, Haemophilus inﬂuenzae and Staphylococcus. Increase in Firmicutes (Streptococcus, Veillonella), Bacteroidetes, and Proteobacteria (Enterobacteriaceae, Rikenellaceae, Prevotella, Streptococcus, Lactobacillus).…”

Section: Mechanisms Regulating Glamentioning

confidence: 99%

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Eladham,

Selvakumar,

Saheb Sharif-Askari

et al. 2024

Heliyon

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“…Furthermore, a theory has been advanced, namely that some essential risk factors for tuberculosis (HIV, malnutrition, diabetes, alcohol, smoking and pollution) interact with the host through the microbiota [ 50 , 51 ].…”

Section: The Role Of Microbiotamentioning

confidence: 99%

Pulmonary Tuberculosis in Children: A Forgotten Disease?

Pelosi¹,

Pintus

Savasta

et al. 2023

Microorganisms

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Even today, tuberculosis in childhood is a disease that is often undiagnosed and undertreated. In the absence of therapy with antituberculosis drugs, children in the first years of life have a high degree of severe forms and mortality. In these children, symptoms are often not very specific and can easily be confused with other diseases of bacterial, viral or fungal etiology, making diagnosis more difficult. Nevertheless, the introduction of new diagnostic techniques has allowed a more rapid identification of the infection. Indeed, Interferon gamma release assay (IGRA) is preferred to the Mantoux, albeit with obvious limitations in children aged <2 years. While the Xpert Mtb/RIF Ultra test is recommended as an initial diagnostic investigation of the gastric aspirate and/or stools in children with signs and symptoms of pulmonary tuberculosis. The drugs used in the treatment of susceptible and resistant TB are the same as those used in adults but doses and combinations are different in the pediatric age. In children, brief therapy is preferable in both the latent infection and the active disease, as a significant reduction in side effects is obtained.

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The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis

Cited by 20 publications

References 126 publications

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

The correlation between dysfunctional intestinal flora and pathology feature of patients with pulmonary tuberculosis

Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay

Pulmonary Tuberculosis in Children: A Forgotten Disease?

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