The Role of Growth Hormone in the Anabolic Action of Methandrostenolone

Steinetz, Bernard G.; Giannina, T.; Butler, Matthew; Popick, F.

doi:10.1210/endo-90-5-1396

Cited by 17 publications

(12 citation statements)

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“…T h e data obtained from these clinical studies provide further supportive evidence of a synergistic interaction between HGH and androgen [8,10,15,171. I n 9 of the 12 children with hypopituitarism participating in our study, linear growth was significantly accelerated by the addition of modest doses of fluoxymesterone to an already standardized H G H regimen.…”

Section: Discussionmentioning

confidence: 57%

“…T h e interactions between growth hormone and androgens have been extensively examined [8,10,13,15,171. Studies carried out in intact animals and humans have shown that androgens increase the pituitary content [4] and enhance pituitary secretion of growth hormone [IO].…”

Section: Discussionmentioning

confidence: 99%

“…Synergism between this anabolic steroid and growth hormone has already been documented in animals [15]. Clinical trials with oxandrolone, a potent anabolic agent with weak androgenic properties, have not shown unfavorable acceleration of bone maturation [3, 91 in short children with intact pituitaries.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is sound experimental proof of synergism between growth hormone and androgen [13,15,161, the combined use of these hormones i n children with hypopituitarism has not been generally recommended because of the risk of accelerating bone maturation.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

1974

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ExtractTwelve hypopituitary patients ranging in age from 58f2 to 15 ?fa years were treated for 12 months with a standardized dose of human growth hormone (HGH), 0.1 or 0.05 U/kg three times weekly). From the 7th to 12th month inclusive, fluoxymesterone, 2.5 mg/m2/24 hr per os was given in combination with the growth hormone. From the 12th to the 18th month, no therapy was given. Heights and weights were recorded every 1 or 2 months. Bone age films were assessed at the onset and again in the 6th, 12th, and 18th month of the study.In the first 6 months of HGH therapy, the mean growth rate (centimeters per year f SD) was 9.4 =t 2.3. During combined treatment with HGH and fluoxymesterone, the mean growth rate of 13.4 f 3 was significantly greater ( P < 0.001) than on HGH alone. Post-treatment mean growth rate from the 13th through 18th month, inclusive, was 2.7 =t 1.2. Weight gain (kilograms per year & SD) during combined treatment (13 =t 7) was significantly greater ( P < 0.001) than during HGH administration (3.4 =t 2.4). Mean advancement in bone maturation (months =t SD) during HGH (12 f 7.7) was not significantly different from the mean gain in bone age during combined treatment (12 =t 12). In the final 6 months without any therapy, the mean gain in bone age was 8.8 f 6.1. In the 18 months of study, the mean increase in bone age was 33 months, and the mean gain in height age (HA) was 23 months.Although final evaluation of this treatment program depends upon a longer period of observation, the immediate assessment suggests that the significant improvements in height, weight, and physical appearance were sufficient to compensate for the gains in bone maturation, especially since the patients who entered the study had markedly retarded bone ages. SpeculationHGH and androgens interact synergistically. Androgens stimulate HGH secretion in intact animals. In the hypopituitary state, androgens require the addition of HGH for optimal promotion of optimal growth and secondary sexual development.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

1974

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“…It is known that hypophysectomy, without further treatment, produces growth arrest and a negative nitrogen balance, which are due, primarily, to a lack of growth hormone [Kocharian and Beall, 1950;M arx et al" 1942;G reenspan et al, 1950;Steinetz et al, 1972]. The weight of the uterus and the amount of uterine secretion also diminished following hypophysectomy, but the relationship between these two parameters remained in an apparently constant ratio.…”

Section: Discussionmentioning

confidence: 99%

The Role of the Pituitary in Modifications of the Uterine Secretion of Spayed, Oestradiol-Primed Rats

Meglioli

Desaulles

1973

Horm Res

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Tests performed on spayed, oestradiol-primed rats with ligated uteri and normal pituitary function have shown that treatment with sexual steroids modifies uterine secretion. Progesterone elicits a decrease in the quantity and an increase in the viscosity of the uterine secretion, an effect also produced by testosterone at very high dose levels. A decrease in the pH of the secretion was also observed. Supplementary oestradiol treatment was devoid of any activity.This paper describes the results obtained when the same experiment was carried out in normal castrate and castrate-hypophysectomized rats. The effects of varying subcutaneous doses of progesterone, testosterone, and oestradiol were compared. In both groups, a number of rats primed with oestradiol only served as controls.Progesterone induced a dose-dependent reduction in the weight of the uterus and in the quantity and pH of the uterine secretion, as well as a marked increase in its viscosity, in both intact and hypophysectomized rats.Testosterone increased the weight of the uterus and, when given in large doses, reduced the pH of both the lumen and secretion. The quantity of the uterine secretion diminished in response to high doses and its viscosity increased markedly only in rats bearing a pituitary.Oestradiol did not elicit significant changes in either group; a slight reduction in the pH of the uterine secretion was observed in response to high doses.It may be concluded that the progestative modifications induced by progesterone in the uterus of spayed, oestradiol-primed rats, including particularly changes in uterine secretion, are the effects of a peripheral mechanism not involving the pituitary. Testosterone appears to be an exception as far as the quantity and viscosity of uterine secretion are concerned, since modifications in these parameters are only observed in the presence of a functional pituitary body.

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Fanconi's Anemia With Growth Hormone Deficiency

Nordan¹

1979

Arch Pediatr Adolesc Med

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The Role of Growth Hormone in the Anabolic Action of Methandrostenolone

Cited by 17 publications

References 0 publications

Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

Enhanced Linear Growth Responses in Hypopituitary Dwarfs Treated with Growth Hormone Plus Androgen versus Growth Hormone Alone

The Role of the Pituitary in Modifications of the Uterine Secretion of Spayed, Oestradiol-Primed Rats

Fanconi's Anemia With Growth Hormone Deficiency

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