The role of glycolysis in immune response

The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various pharmaceutical properties of 2-DG are discussed.

show abstract

“…2-Deoxyglucose (2-DG) is a toxic glucose analog. 2-DG has a pleiotropic mechanism of action (Figure 3) [16][17][18].…”

Section: Pharmaceutical Profile Of 2-dgmentioning

confidence: 99%

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

Singh¹,

Gupta

Kumar

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

View full text Add to dashboard Cite

show abstract

“…2-DG has a pleiotropic mechanism of action. [29][30][31] 2-DG contains a structural resemblance with glucose and mannose. Due to this resemblance with mannose, 2-DG strongly interferes in the N-linked glycosylation process, 29 resulted to halt protein synthesis and cause endoplasmic reticulum (ER) stress.…”

Section: Toxicology and Handling Of 2-dgmentioning

confidence: 99%

A review on synthetic methods for 2-deoxy-D-glucose

Singh¹,

Singh²,

Gupta³

2023

Arkivoc

View full text Add to dashboard Cite

2-Deoxy-D-glucose (2-DG) is a non-metabolizable glucose analog that has shown promising pharmacological activities and has been used to study the role of glucose in cancer cells. 2-DG is an inhibitor of glycolysis, potential Energy Restriction Mimetic agent and inhibits pathogen-associated molecular patterns. Its radioisotope derivatives have application as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug lowering the need for supplemental oxygen. In this review, different synthetic strategies for preparation of 2-DG including enzymatic synthesis have been discussed. The understanding of these methods would help in developing therapeutics or diagnostic agents aimed at exploring therapeutic targets related with energy metabolism.

show abstract

“…Дифференцировка Т-лимфоцитов связана с активацией разных метаболических путей. Для Тh1-, Th2-и Th17-клеток -это гликолиз, а для регуляторных Т-клеток (Treg) -цикл окис-ления жирных кислот и OXPHOS [2,4]. Для оценки метаболических процессов в клетках используют различные методы: проточную цитометрию, масс-спектрометрию, технологию Seahorse и др.…”

unclassified