2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

Singh, Raman; Gupta, Vidushi; Kumar, Antresh; Singh, Kuldeep

doi:10.1155/2023/9993386

Advances in Pharmacological and Pharmaceutical Sciences

2023

DOI: 10.1155/2023/9993386

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2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

Raman Singh¹,

Vidushi Gupta

Antresh Kumar

et al.

Abstract: The nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) has shown promising pharmacological activities, including inhibition of cancerous cell growth and N-glycosylation. It has been used as a glycolysis inhibitor and as a potential energy restriction mimetic agent, inhibiting pathogen-associated molecular patterns. Radioisotope derivatives of 2-DG have applications as tracers. Recently, 2-DG has been used as an anti-COVID-19 drug to lower the need for supplemental oxygen. In the present review, various p… Show more

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Cited by 3 publications

References 142 publications

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Molecular analysis of dUTPase of Helicobacter pylori for identification of novel inhibitors using in silico studies

Sisodia,

Sarmadhikari,

Mazumdar

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Molecular analysis of dUTPase of Helicobacter pylori for identification of novel inhibitors using in silico studies

Sisodia,

Sarmadhikari,

Mazumdar

et al. 2023

Journal of Biomolecular Structure and Dynamics

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2-Deoxyglucose Promotes Anti-Inflammatory Polarization of Peritoneal Macrophages in Mice With Lewis Lung Carcinoma

Stepanov,

Yakshibaeva,

Kolesnik

et al. 2024

Oncology

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Summary. Aim: to investigate the effect of 2-deoxyglucose at a wide range of concentrations on the polarization of peritoneal macrophages of intact mice and mice with Lewis lung carcinoma. Object and methods: peritoneal macrophages obtained from intact female C57BL/6 mice and Lewis lung carcinoma-bearing mice. isolation of peritoneal macrophages, determination of nitric oxide production and arginase activity. Results: 2-deoxyglucose does not affect nitric oxide production and arginase activity of peritoneal macrophages of intact mice. 2-deoxyglucose at a concentration of 10 mM significantly (by 17%, p<0.05) increases arginase activity in peritoneal macrophages of mice with Lewis lung carcinoma. Conclusions: It was revealed that peritoneal macrophages in mice with Lewis lung carcinoma have a pro-inflammatory M1 phenotype. The addition of 2-deoxyglucose at a concentration of 10 mM to the incubation medium of peritoneal macrophages obtained from mice with Lewis lung carcinoma promotes a switch in macrophage polarization to the M2 phenotype.

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Network Pharmacology and Experimental Validation of Qingwen Baidu Decoction Therapeutic Potential in COVID-19-related Lung Injury

Yang,

Zhang,

Liu

et al. 2024

CCHTS

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Background and Purpose: Coronavirus disease 2019 (COVID-19) is a lifethreatening disease worldwide due to its high infection and serious outcomes resulting from acute lung injury. Qingwen Baidu decoction (QBD), a well-known herbal prescription, has shown significant efficacy in patients with Coronavirus disease 2019. Hence, this study aims to uncover the molecular mechanism of QBD in treating COVID-19-related lung injury. Methods:: Traditional Chinese Medicine Systems Pharmacology database (TCMSP), DrugBanks database, and Chinese Knowledge Infrastructure Project (CNKI) were used to retrieve the active ingredients of QBD. Drug and disease targets were collected using UniProt and Online Mendelian Inheritance in Man databases (OMIM). The core targets of QBD for pneumonia were analyzed by the Protein-Protein Interaction Network (PPI), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) to reveal the underlying molecular mechanisms. The analysis of key targets using molecular docking and animal experiments was also validated. Results:: A compound-direct-acting target network mainly containing 171 compounds and 110 corresponding direct targets was constructed. The key targets included STAT3, c-JUN, TNF-α, MAPK3, MAPK1, FOS, PPARG, MAPK8, IFNG, NFκB1, etc. Moreover, 117 signaling pathways mainly involved in cytokine storm, inflammatory response, immune stress, oxidative stress and glucose metabolism were found by KEGG. The molecular docking results showed that the quercetin, alanine, and kaempferol in QBD demonstrated the strongest affinity to STAT3, c- JUN, and TNF-α. Experimental results displayed that QBD could effectively reduce the pathological damage to lung tissue by LPS and significantly alleviate the expression levels of the three key targets, thus playing a potential therapeutic role in COVID-19. Conclusion:: QBD might be a promising therapeutic agent for COVID-19 via ameliorating STAT3-related signals.

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2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities

Cited by 3 publications

References 142 publications

Molecular analysis of dUTPase of Helicobacter pylori for identification of novel inhibitors using in silico studies

Molecular analysis of dUTPase of Helicobacter pylori for identification of novel inhibitors using in silico studies

2-Deoxyglucose Promotes Anti-Inflammatory Polarization of Peritoneal Macrophages in Mice With Lewis Lung Carcinoma

Network Pharmacology and Experimental Validation of Qingwen Baidu Decoction Therapeutic Potential in COVID-19-related Lung Injury

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