The role of glutathione in the regulation of nucleotide excision repair during oxidative stress

Langie, Sabine A. S.; Knaapen, Ad M.; Houben, Joyce M.J.; Kempen, Frederik C. van; Hoon, Joep P.J. de; Gottschalk, Ralph W.H.; Godschalk, Roger; Schooten, Frederik J. van

doi:10.1016/j.toxlet.2006.10.027

Cited by 59 publications

(35 citation statements)

References 30 publications

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“…GSH-depletion in cells preincubated with BSO, l-buthionine-sulfoximine, completely abolished the downregulation of ERCC1 expression and the decrease in NER capacity by H 2 O 2 and increased significantly the upregulation of ERCC4 expression. These data suggest that NER capacity as well as the expression of NER-related genes can be modulated by oxidative stress (114).…”

Section: B Direct Regulation Of Dna Repair By Altered Redox Status Omentioning

confidence: 71%

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Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Luo

Kelley

et al. 2010

Antioxidants & Redox Signaling

113

136

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Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair. Antioxid. Redox Signal. 12, 1247-1269.

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Section: B Direct Regulation Of Dna Repair By Altered Redox Status Omentioning

confidence: 71%

“…On exposure of human pulmonary epithelial cells (A549) to nontoxic doses of H 2 O 2 , increased expression of XPA, XPC, ERCC4, and ERCC5 was observed, whereas ERCC1 expression decreased (114). Functional studies also demonstrated a decrease in NER activity.…”

Section: B Direct Regulation Of Dna Repair By Altered Redox Status Omentioning

confidence: 97%

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Luo

Kelley

et al. 2010

Antioxidants & Redox Signaling

113

136

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“…Conversely, the NER-mediated repair of 8-oxodG results in the excision of a lesion-containing oligomer, 24 to 29 nucleotides in length, followed by subsequent reduction to 6-to 7-mers (44). GSH and Trx1 systems can protect against introduction of damage and also regulate expression of DNA-repair genes or modify activity of proteins by glutathionylation (103).…”

Section: Redox-sensitive Transcriptional Regulationmentioning

confidence: 99%

Redox Control Systems in the Nucleus: Mechanisms and Functions

Jones

2010

Antioxidants & Redox Signaling

176

125

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Proteins with oxidizable thiols are essential to many functions of cell nuclei, including transcription, chromatin stability, nuclear protein import and export, and DNA replication and repair. Control of the nuclear thioldisulfide redox states involves both the elimination of oxidants to prevent oxidation and the reduction of oxidized thiols to restore function. These processes depend on the common thiol reductants, glutathione (GSH) and thioredoxin-1 (Trx1). Recent evidence shows that these systems are controlled independent of the cytoplasmic counterparts. In addition, the GSH and Trx1 couples are not in redox equilibrium, indicating that these reductants have nonredundant functions in their support of proteins involved in transcriptional regulation, nuclear protein trafficking, and DNA repair. Specific isoforms of glutathione peroxidases, glutathione Stransferases, and peroxiredoxins are enriched in nuclei, further supporting the interpretation that functions of the thiol-dependent systems in nuclei are at least quantitatively distinct, and probably also qualitatively distinct, from similar processes in the cytoplasm. Elucidation of the distinct nuclear functions and regulation of the thiol redox pathways in nuclei can be expected to improve understanding of nuclear processes and also to provide the basis for novel approaches to treat aging and disease processes associated with oxidative stress in the nuclei. Antioxid. Redox Signal. 13, 489-509.

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“…ERCC5 suppresses UV-induced apoptosis through its endonuclease function (Clément et al, 2006) and also through the extrinsic apoptotic pathway involving caspases, but not p53 (Clément et al, 2007). The expression of this gene, as with other members of NER, could be modulated by oxidative stress (Langie et al, 2007). The XRCC5 is involved in mammalian DNA double-strand break repair process and in the mechanisms of genetic stability (Thacker and Zdzienicka, 2004).…”

Section: Figmentioning

confidence: 99%

Mononuclear Cell Transcriptome Response after Sustained Virgin Olive Oil Consumption in Humans: An Exploratory Nutrigenomics Study

Khymenets

Fitó

Covas

et al. 2009

OMICS: A Journal of Integrative Biology

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Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) play a crucial role in atherosclerosis development and progression. The objective of this article was to identify the PBMNC genes that respond to VOO consumption in order to ascertain the molecular mechanisms underlying the beneficial action of VOO in the prevention of atherosclerosis. Gene expression profiles of PBMNCs from healthy individuals were examined in pooled RNA samples by microarrays after 3 weeks of moderate and regular consumption of VOO, as the main fat source in a diet controlled for antioxidant content. Gene expression was verified by qPCR. The response to VOO consumption was confirmed for individual samples (n ϭ 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TN-FSF10, USP48, and XRCC5). Their putative role in the molecular mechanisms involved in atherosclerosis development and progression is discussed, focusing on a possible relation with VOO consumption. Our data support the hypothesis that 3 weeks of nutritional intervention with VOO supplementation, at doses common in the Mediterranean diet, can alter the expression of genes related to atherosclerosis development and progression. 7

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The role of glutathione in the regulation of nucleotide excision repair during oxidative stress

Cited by 59 publications

References 30 publications

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Redox Control Systems in the Nucleus: Mechanisms and Functions

Mononuclear Cell Transcriptome Response after Sustained Virgin Olive Oil Consumption in Humans: An Exploratory Nutrigenomics Study

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