The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model

Prem, Jeffrey T; Eppinger, Michael J.; Lemmon, Gary W.; Miller, Sidney F.; Nolan, Dan; Peoples, James B.

doi:10.1016/s0002-9610(99)00148-8

Cited by 65 publications

(32 citation statements)

References 12 publications

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“…Mates et al (2002) demonstrated that glutamine is used to supply glutamate and cysteine, perhaps for glutathione biosynthesis. Glutamine has been shown to preserve total glutathione levels after injury/ischemia (Prem et al 1999). The quenching of reactions mediated by reactive oxygen species decreases oxidized protein levels and normalizes enzyme activities.…”

mentioning

confidence: 99%

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Anandan¹,

Kumar²,

Ganesan³

et al. 2013

Egypt. J. Bio.

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Myocardial infarction is a major public health concern and the leading cause of death all over the world. A better understanding of the processes involved in myocardial infarction has stimulated the search for biomolecules, which could limit the myocardial injury. We determined the protective activity of L-glutamine on mitochondrial function in isoprenalineinduced myocardial infarction in rats, an animal model of myocardial infarction in man. Oral pre-treatment with glutamine significantly inhibited the isoprenaline-induced changes in the levels of troponin T and homocysteine in the plasma. It conserved the activities of tricarboxylic acid cycle enzymes (isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase) and respiratory marker enzyme (NADH dehydrogenase) and the level of myocardial ATP content at levels comparable to that of normal controls. It also attenuated isoprenaline-induced oxidative stress in rat mitochondria and preserved the antioxidant defence system at near normal. The results indicate that the cardioprotective effect of glutamine can be correlated directly with its ability to activate the energy status and antioxidant defence system.

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mentioning

confidence: 99%

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Anandan¹,

Kumar²,

Ganesan³

et al. 2013

Egypt. J. Bio.

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“…In our study, serum lactate level seemed to be elevated after 2-h ischemia followed by 2-h reperfusion in I/R and I/R + NAR groups compared with the control group; however, these increases were not statistically significant. On the other hand, Prem et al have reported increased blood CK activity in their study in which they applied 2-h ischemia followed by 30 min of reperfusion in rat model of I/R study in skeletal muscles 67 . CK (E.C.…”

Section: Discussionmentioning

confidence: 90%

Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Gürsul

Akdemir

Akkoyun

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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This study was designed to investigate the antioxidant effects of Naringin, in ischemia/ reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p50.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p50.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p50.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.

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“…However, the accurate mechanism of protective effect of the GLN against the I/R injury of organs and tissue is not yet completely understood. GLN protects against I/R injury in the intestine, heart and skeletal muscle by preserving the content of GSH in those tissues 18 . Apoptosis or programmed cell death is a process to eliminate damaged or abnormal cells in multicellular organisms, and it represents a common mechanism of cell replacement and tissue remodeling 20 .…”

Section: Discussionmentioning

confidence: 99%

Preconditioning with L-alanyl-glutamine reduces hepatic ischemia-reperfusion injury in rats

Júnior¹,

Júnior²,

Vasconcelos³

et al. 2011

Acta Cir. Bras.

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The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model

Cited by 65 publications

References 12 publications

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Antioxidant defence of L-glutamine on mitochondrial function in experimentally induced myocardial infarction in rats

Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Preconditioning with L-alanyl-glutamine reduces hepatic ischemia-reperfusion injury in rats

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