The role of genomic instability and expression of the p53 protein gene network in the processes of oncogenesis in first- and second-generation children living in radioactively contaminated areas

Балева, Л. С.; Sukhorukov, V. S.; Sipyagina, A. E.; Karakhan, N. M.; Voronkova, A. S.; Sadykov, A. R.

doi:10.21508/1027-4065-2017-62-1-81-86

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Анализ данных в семейном аспекте выявил схожие изменения в экспрессии генов, как у матерей, так и у их детей, причем у детей эти изменения были более ярко выражены. Таким образом, проведенное нами исследование экспрессии генной сети гена ТP53 позволяет предполагать возможность трансгенерационной передачи специфических последствий облучения и, соответственно, риска развития онкологических заболеваний [23].…”

Section: характеристика экспрессии генов генной сети белка р53unclassified

Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Балева¹,

Сипягина²

2019

Ross. vestn. perinatol. pediatr.

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Section: характеристика экспрессии генов генной сети белка р53unclassified

Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Балева¹,

Сипягина²

2019

Ross. vestn. perinatol. pediatr.

Self Cite

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Adverse anthropogenic factors – a threat to the genetic and somatic health of children

Yurieva,

Dlin,

Kushnareva

et al. 2024

Ross. vestn. perinatol. pediatr.

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The authors, based on a large number of studies (including their own) regarding the toxic effects of heavy and radioactive metals on children of different ages and with varying degrees of chronic exposure to such metals, present the risks of developing somatic and genetic diseases. The main mechanisms of the influence of the radiation factor on the child’s body and the causes of the formation of radiation-induced diseases are shown.

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Heritable effects in offspring associated with harmful exposure to parents (Literature review)

Sosnina

Sokolnikov

2019

Radiac. gig. (2008)

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A review of literature data regarding the heritable effects in offspring due to parents’ contact with mutagenic risk factors is presented. Studies on various factors of adverse effects on the hereditary apparatus, including chemical, infectious, physical and biological, are considered. The influence of smoking and parents’ age on the occurrence of de novo mutations is shown. Particular attention is paid to the review of publications on the role of the radiation factor in the genesis of hereditary disorders in offspring. Development stages of radiation genetics, the evolution of conception about radiation harm are described. The results of experimental, cytogenetic, molecular genetic, epidemiological studies analyzing the contribution of parental exposure to inherited pathology in progeny are presented. Special attention is paid to the “untargeted” effects of radiation and studies which prove the possibility of transgenerative transmission of genome instability are presented. The special contribution of studies on the cohort of atomic bomb victims offspring in Hiroshima and Nagasaki, which is considered as the main scientific platform for radiation risk assessment, is noted. There are articles about the offspring of persons who underwent therapeutic exposure, who had professional contact with ionizing radiation, who were exposed to radiation as a result of the Chernobyl accident, nuclear weapons tests at the Semipalatinsk test site, chronic radiation in the radioactively contaminated territory of the Techa river, areas with naturally increased radioactivity. As a result, it was noted that, despite numerous confirmations of radiation-induced effects in offspring obtained within experimental and molecular genetic studies, the results of epidemiological studies remain controversial. Possible reasons for these discrepancies are considered. An idea of views evolution regarding heritable effects in the international system of radiation safety is given. A new approach of the International Commission on Radiological Protection to heritable effects is described; the dynamics of tissue weighting factors for gonads in the assessment of effective radiation dose is shown. Methods for evaluating heritable effects are presented: the direct method and the doubling dose method. Attention is focused on the uncertainties that remain in the modern assessment of radiation genetic damage. The necessity of further study of radiation-induced heritable effects is shown. The perspective directions of studying the heritable effects are considered. The possibility of the analysis of heritable effects is described using the example of a cohort of the Mayak Production Association workers’ offspring – the country’s first nuclear industry enterprise.

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The role of genomic instability and expression of the p53 protein gene network in the processes of oncogenesis in first- and second-generation children living in radioactively contaminated areas

Cited by 3 publications

References 7 publications

Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Urgent problem of our time: the risk of developing radiation-induced stochastic diseases in the generations of children from irradiated parents

Adverse anthropogenic factors – a threat to the genetic and somatic health of children

Heritable effects in offspring associated with harmful exposure to parents (Literature review)

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