The role of gallium-67 in the clinical evaluation of cancer

Bekerman, Carlos; Hoffer, Paul B.; Bitran, Jacob D.

doi:10.1016/s0001-2998(84)80005-7

Cited by 97 publications

(31 citation statements)

References 109 publications

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“…Despite its established role in the evaluation of high-grade NHL and HD, the sensitivity of Ga-67 scintigraphy is limited with its lower resolution limits in tumors smaller than 2 cm. 30 Single positron emission computed tomography images provide cross-sectional images and hence have higher resolution and sensitivity for lesion detection than planar images. 31 In our series, Ga-67 SPECT missed 35.7% of the lesions (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…5,[7][8][9][10][11] It is widely accepted that Ga-67 is an indicator of tumor viability, notwithstanding that its sensitivity is highly dependent on the cell type and the size and the location of the lesion. 12 Ga-67 is more sensitive in Hodgkin disease (HD) and aggressive lymphomas than in lowgrade lymphoma for lesions of greater than 2 cm in dimension, and in the mediastinum. It is often difficult to differentiate possible disease sites from physiologic uptake in the abdomen with Ga-67 scintigraphy; thus, the sensitivity and specificity of this technique are low for tumors located in the abdomen.…”

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confidence: 99%

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Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma

Kostakoğlu

Leonard

Kuji

et al. 2002

Cancer

179

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Ga-67 SPECT failed to demonstrate disease at 45 sites (35.7%). In 10 of 44 patients, Ga-67 SPECT completely failed to detect any disease at 22 of 45 sites (17.5%) and partially identified disease sites at 23 of 45 sites (18.2%) in 11 patients regardless of the tumor site and histology. In these patients, the lesions measured between 0.6 and 14.0 cm by CT. Fluorodeoxyglucose positron emission tomography revealed higher stage disease in 13 patients compared with Ga-67 imaging. Tumor-tobackground ratios were statistically different between the two techniques with

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma

Kostakoğlu

Leonard

Kuji

et al. 2002

Cancer

179

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“…En iyi hedef/zemin aktivite oranına 48-72 saatte ulaşılır. Düşük özgüllüğü yanında, uzun fiziksel yarı ömrü, yüksek enerjili gama ışını, görüntülemede dezavantajları olup hasta ile personel yüksek radyasyon dozuna maruz kalır (22,23). Tanısal doğruluğu %60-80 civarındadır (1).…”

Section: Ga-67sitratunclassified

Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

Eren¹,

Bekiş²

2017

Nts

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“…Ga) has been used for the detection of various tumors 1,2) and acute and chronic inflammations, 3,4) since the first observation of its accumulation in tumors 5) and inflammatory lesions. 6,7) Moreover, in chronic hepatitis C, it was reported that there was more accumulation in the liver in patients with chronic persistent hepatitis than in those with cirrhosis.…”

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Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

Abe

Suyama

Shishido

et al. 2004

Biological & Pharmaceutical Bulletin

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Gallium-67 ( 67 Ga) has been used as a tumor or inflammation-imaging agent in nuclear medicine. We recently reported that the peak of serum alanine aminotransferase (ALT) level was 1 d after carbon tetrachloride (CCl 4 ) treatment in rats. However, the peak of Ga by the hepatocytes is carried out during liver regeneration rather than during hepatic disorder by CCl 4 treatment. 67 Ga); carbon tetrachloride (CCl 4 ); liver tissue; hepatocyte; lipid peroxidation; bromodeoxyuridine (BrdU) (w/v) trichloroacetic acid, 0.375% (w/v) thiobarbituric acid dissolved in 0.25 M of hydrochloric acid], the mixture was heated for 15 min in a boiling water bath. After cooling, the precipitate was removed by centrifugation at 2000ϫg for 10 min. Following decanting of the supernatant, the absorbance was determined at 535 nm against a blank that contained all the reagents minus sample. The MDA concentration from the samples was calculated using an extinction coefficient of 1.56ϫ10 Key words. The results were expressed as the concentration of MDA/mg protein.Flow Cytometric Analysis of Cell Cycle Cell cycle was analyzed using a BrdU Flow Kit (Becton Dickinson, San Diego, CA, U.S.A.). BrdU was dissolved in phosphate buffered saline (PBS) and was given intravenously (10 mg/kg) 2 h before killing. Incorporation of BrdU into hepatocytes was detected by FACScan (Becton Dickinson). RESULTS Changes in the Lipid Peroxidation of Hepatocytes from CCl 4 -Treated MiceTo ascertain the degree of disorder in the hepatocytes, we determined the lipid peroxidation by thiobarbituric acid assay (Fig. 1). The peroxidation increased after CCl 4 treatment and showed the highest value (7.2 times higher than that of normal mice) 1 d after the treatment.Changes in Serum ALT Level after CCl 4 Treatment Serum ALT level also increased after CCl 4 treatment and reached a maximum in 1 d (Fig. 2). Two days after the treatment the value rapidly decreased. (Fig. 3), while the uptake of 67 Ga by the hepatocytes showed the highest value (8.5 times higher than that of normal mice) 2 d after treatment (Fig. 4). Changes in the Incorporation of Bromodeoxyuridine into Hepatocytes after CCl 4 TreatmentTo confirm DNA synthesis of hepatocytes during liver regeneration after CCl 4 -induced hepatic disorder, we determined their incorporation of BrdU (Fig. 5). Incorporation reached a maximum 2 d after CCl 4 treatment. DISCUSSIONWe recently reported that serum ALT level of CCl 4 -treated rat reached a maximum 1 d after the treatment, whereas the uptake of 67 Ga by the liver tissue and hepatocytes was highest 2 d after treatment. 9)In the present study, we confirmed the precise index of disordered hepatocytes by the degree of lipid peroxidation (Fig. 1). The lipid peroxidation of hepatocytes from CCl 4 -treated mice was greatly increased within 1 d of the treatment. Furthermore, serum ALT (a conventional indicator of hepatic disorder) was also increased within 1 d (Fig. 2). This result was consistent with that of CCl 4 -treated rats, 9) and indicated that hepatocyte destruc...

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The role of gallium-67 in the clinical evaluation of cancer

Cited by 97 publications

References 109 publications

Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma

Comparison of fluorine‐18 fluorodeoxyglucose positron emission tomography and Ga‐67 scintigraphy in evaluation of lymphoma

Patient and Personnel Radiation Exposure in Sentinel Lymph Node Practice

Uptake of Gallium-67 by the Hepatocytes during Liver Regeneration in Carbon Tetrachloride-Treated Mice

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