The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents

Altenburg, Sonia P.; Ventura, Diana G; Da-Silva, V. A.; Malheiros, Luciana Reis; Castro‐Faria‐Neto, Hugo C.; Bozza, Patrı́cia T.; Teixeira, Nancy Airoldi

doi:10.1016/s0278-5846(01)00335-9

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…In the literature, it has been speculated that this phenomenon could be attributed to a synergistic effect between LPS and the release of corticosteroids in the body. The latter condition leads the animal to produce a higher level of chemo attractant cytokines such as interleukin 1 (IL-1) and necrosis factor alpha (FNTa), which stimulate the release of immature cells from the bone marrow into the circulation (ALTENBURG et al, 2002 Neutrophil count averages are presented in Figure 2c. The control group had a baseline count of 2763.4 ± 538.8 μL -1 neutrophils, remaining at similar averages throughout the sampling period.…”

Section: Resultsmentioning

confidence: 99%

CLINICAL AND HEMATOLOGICAL CHANGES IN SHEEP INDUCED BY Escherichia coli LIPOPOLYSACCHARIDE

Riquelme¹,

Cazanga²,

Palma³

et al. 2018

ArqVet

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Organic response to infection is characterized by a systemic reaction known as acute phase response (APR). In order to know the effect of the administration of Escherichia coli lipopolysaccharide (LPS) on physiological, hematological and biochemical variables, 10 sheep weighing 45 ± 5 kg were divided in two groups: Experimental group treated with 3 doses of 1 μg.kg-1 LPS and control group treated with saline solution (SS) at the same frequency as experimental group. Body temperature (BT°), heart rate (HR) and respiratory rate (RR) were monitored. Blood samples for hemogram and enzyme activity for aspartate amino transferase (AST) and gamma glutamyl transferase (GGT) were collected between 1 and 24 h post-LPS.LPS-treated sheep presented mean values of BT°, HR and RR higher than those observed in control sheep. At 4 and 8 hours post-injection (hpi) of LPS the leukocyte count was associated with lymphopenia, followed by leukocytosis at 24 hours. No changes were observed in the activity of AST and GGT enzymes. The results characterize APR induced by LPS in sheep, representing a useful model to study cardiovascular, hematological and biochemical responses to infection.

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Section: Resultsmentioning

confidence: 99%

CLINICAL AND HEMATOLOGICAL CHANGES IN SHEEP INDUCED BY Escherichia coli LIPOPOLYSACCHARIDE

Riquelme¹,

Cazanga²,

Palma³

et al. 2018

ArqVet

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“…Mice that had been transgenically modified to exhibit a depressive type of behavior (catalepsy) and were inoculated with sheep red blood cells (SRBC) had lower amounts of platelet-forming cells and antigen-specific T lymphocytes than their parents without this d i s o r d e r . I n r a t s w i t h h i g h l e v e l s o f a n x i e t y , l o w e r concentrations of specific T lymphocytes were also found five days after inoculation with SRBC (Kubera et al, 1996;Pedersen & Hoffman-Goetz, 2000;Altenburg et al, 2002;Robles et al, 2005;Alperin et al, 2007;Loskutov et al, 2007;Miller, 2010).…”

mentioning

confidence: 95%

“…In addition to the psychological changes associated with depression, immune system changes are often found in depressed individuals (Altenburg et al, 2002). Several studies have indicated that stress and depression involve the individual in a chronic process that results in host defense failure against microorganisms and a higher likelihood of developing certain cancers.…”

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confidence: 99%

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Fernandes¹,

Venâncio²,

Estanislau³

2012

Effects of Antidepressants

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“…Além das alterações psicológicas mencionadas acima, a depressão pode interferir no funcionamento do sistema imunológico (Altenburg et al, 2002). O sistema imunológico é formado por um conjunto de mecanismos de proteção do organismo contra elementos estranhos (Guyton & Hall, 2002).…”

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“…Modelos animais de estresse e/ou de depressão têm mostrado alterações no sistema imunológico, incluindo o aumento na produção de IL-1 e do número de neutrófilos circulantes e menor resistência a infecção por bactérias (Kubera et al, 1996;Pedersen & Hoffman-Goetz, 2000;Altenburg et al, 2002;Robles et al, 2005;Miller, 2010). Camundongos com predisposição a cataplexia (perda de tônus muscular), a qual pode ser revertida com antidepressivos, cinco dias após uma inoculação com hemácias de carneiro, caracterizaram-se por menor quantidade de linfócitos B que animais controle não-inoculados (Alperina, Kulikov, Popova, & Idova, 2007).…”

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Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

Fernandes

Ramos

Estanislau

et al. 2012

Psic.: Teor. e Pesq.

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RESUMO -No presente trabalho, os efeitos comportamentais e imunomoduladores da fluoxetina foram avaliados num modelo animal de depressão, o nado forçado. Nesse, o comportamento de flutuar é sensível a antidepressivos e é usado como índice de desespero comportamental. Foram utilizados dois grupos experimentais, sendo um grupo controle tratado com salina e outro grupo teste tratado com a fluoxetina, ambos administrados por via intra-peritoneal. Os animais foram tratados três vezes ao dia por 12 dias. Adicionalmente, a resposta imune humoral a uma imunoestimulação (hemácias de carneiro) foi avaliada. A fluoxetina provocou aumento no tempo em flutuação, queda na massa corporal e menor produção total de anticorpos. Os resultados indicam uma modulação simultânea do comportamento e do sistema imunológico pela fluoxetina.Palavras-chave: imunomodulação, massa corporal, nado forçado, fluoxetina. Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced SwimmingABSTRACT -In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies.The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.

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The role of forced swim test on neutrophil leukocytosis observed during inflammation induced by LPS in rodents

Cited by 4 publications

References 24 publications

CLINICAL AND HEMATOLOGICAL CHANGES IN SHEEP INDUCED BY Escherichia coli LIPOPOLYSACCHARIDE

CLINICAL AND HEMATOLOGICAL CHANGES IN SHEEP INDUCED BY Escherichia coli LIPOPOLYSACCHARIDE

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

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